Developmental Epidemiology of Pediatric Anxiety Disorders

Warner, Emily N.; Ammerman, Robert T.; Glauser, Tracy A.; Pestian, John; Agasthya, Greeshma

doi:10.1016/j.chc.2023.02.001

Cited by 6 publications

(1 citation statement)

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“…The core features of AD contain indiscriminate anxiety and fear or elusion of persistent and debilitating threats, resulting in substantial medical costs and a burdensome morbidity burden [ 1 , 2 ]. As one of the most popular mental illnesses among young individuals, AD are also the earliest-onset mental disorders [ 3 ]. Amidst the COVID-19 pandemic, there has been a significant surge in the occurrence of AD among children, adolescents, and young adults globally [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study

Li,

Fan,

Wang

et al. 2024

BMC Psychiatry

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Background There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and the brain-gut axis is also a hot topic in current research. However, the specific relevance between gut microbiota and AD is uncertain. We aimed to investigate causal relationship between gut microbiota and AD by using bidirectional Mendelian randomization (MR). Methods Genetic instrumental variable (IV) for the gut microbiota were obtained from a genome-wide association study (GWAS) involving 18,340 participants. Summary data for AD were derived from the GWAS and included 158,565 cases and 300,995 controls. We applied the inverse variance weighted (IVW) method as the main analysis. Cochran’s Q values was computed to evaluate the heterogeneity among IVs. Sensitivity analyses including intercept of MR-Egger method and MR-PRESSO analysis were used to test the horizontal pleiotropy. Result We discovered 9 potential connections between bacterial traits on genus level and AD. Utilizing the IVW method, we identified 5 bacterial genera that exhibited a direct correlation with the risk of AD: genus Eubacteriumbrachygroup, genus Coprococcus3, genus Enterorhabdus, genus Oxalobacter, genus Ruminiclostridium6. Additionally, we found 4 bacterial genera that exhibited a negative association with AD: genus Blautia, genus Butyricicoccus, genus Erysipelotrichaceae-UCG003 and genus Parasutterella. The associations were confirmed by the sensitivity analyses. Conclusion Our study found a causal relation between parts of the gut microbiota and AD. Further randomized controlled trials are crucial to elucidate the positive effects of probiotics on AD and their particular protection systems.

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