Developmental evaluation of a potential non-steroidal estrogen: triclosan

Foran, Christy M.; Bennett, Erin R.; Benson, William H.

doi:10.1016/s0141-1136(00)00080-5

Cited by 192 publications

(93 citation statements)

References 4 publications

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“…The dorsal fins of male fish also decreased in the length after exposure to this chemical. It is well known that the administration of an estrogen is an ability to transform the male to female phenotypes in the dorsal and anal fin of Japanese medaka (Iwamatsu 1999, Foran et al 2000. Therefore, pendimethalin may suppress the growth of the male dorsal fin by inhibiting AR expression levels and, thus, correspond with the previous reports of , which showed that AR transcript levels decreased and male anal fins were shortened in Thai medaka that were exposed to xeno-oestrogenic mestranol.…”

Section: Discussionsupporting

confidence: 85%

Effects of the Herbicide Pendimethalin on Hormone Receptor Expressions and Dorsal Fin Biometrics in Thai Medaka, <I>Oryzias Minutillus</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Ngamniyom

Panyarachun

2012

Acta Icth et Piscat

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Ngamniyom A., Panyarachun B. 2012. Effects of the herbicide pendimethalin on hormone receptor expressions and dorsal fin biometrics in Thai medaka, Oryzias minutillus (Actinopterygii: Beloniformes: Adrianichthyidae). Acta Ichthyol. Piscat. 42 (3) 239-246.Background. Xeno-oestrogens have negative effects on the endocrine systems of wildlife including freshwater fish. Pendimethalin is a herbicide found in the environment which exerts some oestrogenic action in vivo. Dwarf medaka (known also as Thai medaka), Oryzias minutillus Smith, 1945, inhabit the natural aquatic environments. Dorsal fin of this species is a secondary sex character controlled by sex hormones and assumes as a sensitive bioindicator for testing of oestrogenic chemicals. In this study, we aimed to examine the pendimethalin effects on hormone receptor expressions and dorsal fin biometrics in adult Thai medaka. Materials and methods. Pendimethalin effects on the androgen receptor (AR) and estrogen receptor (ER) β expressions in dorsal fins were determined by semi-quantitative RT-PCR. The fin biometry was presented as the values (%) of the dorsal fin length (DFL) divided by the standard length (SL).Results. In males, AR levels decreased when the fish were exposed to 0.1 µg · mL -1 pendimethalin for 60 days and were exposed to 1 µg · mL -1 for 30 and 60 days. In females, a 60-day treatment with 1 µg · mL -1 caused AR levels to decrease. Conversely, in males, ERβ levels increased after 30 and 60 days of treatment with 1 µg · mL -1 . In females, ERβ levels increased after 30 days of treatment with 1 µg · mL -1 and 60 days of treatment with 0.1 µg · mL -1 . In males, values of DFL/SL% decreased after exposure to 1 µg · mL -1 for 60 days. Additionally, we observed 4 testis-ova among 30 gonads from males treated with 1 µg · mL -1 for 60 days. Conclusion.Our results suggest that pendimethalin may interfere with endocrine processes via hormone receptors, leading to the feminisation of dorsal fins and gonads in Thai medaka.

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Section: Discussionsupporting

confidence: 85%

Effects of the Herbicide Pendimethalin on Hormone Receptor Expressions and Dorsal Fin Biometrics in Thai Medaka, <I>Oryzias Minutillus</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Ngamniyom

Panyarachun

2012

Acta Icth et Piscat

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“…Although individual compounds were generally detected at low-levels, total concentrations of the OWCs commonly exceeded 1 µg/L ( Figure 5). In addition, 33 of the 95 target OWCs are known or suspected to exhibit at least weak hormonal activity with the potential to disrupt normal endocrine function (4,7,8,10,12,22,36,37,(48)(49)(50), all of which were detected in at least one stream sample during this study ( Table 1). The maximum total concentration of hormonally active compounds was 57.3 µg/ L. Aquatic species exposed to estrogenic compounds have been shown to alter normal hormonal levels (7,48,51).…”

Section: Resultsmentioning

confidence: 82%

Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance

Kolpin

Furlong

Meyer

et al. 2002

Environ. Sci. Technol.

7,230

102

4,125

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To provide the first nationwide reconnaissance of the occurrence of pharmaceuticals, hormones, and other organic wastewater contaminants (OWCs) in water resources, the U.S. Geological Survey used five newly developed analytical methods to measure concentrations of 95 OWCs in water samples from a network of 139 streams across 30 states during 1999 and 2000. The selection of sampling sites was biased toward streams susceptible to contamination (i.e. downstream of intense urbanization and livestock production). OWCs were prevalent during this study, being found in 80% of the streams sampled. The compounds detected represent a wide range of residential, industrial, and agricultural origins and uses with 82 of the 95 OWCs being found during this study. The most frequently detected compounds were coprostanol (fecal steroid), cholesterol (plant and animal steroid), N,N-diethyltoluamide (insect repellant), caffeine (stimulant), triclosan (antimicrobial disinfectant), tri(2-chloroethyl)phosphate (fire retardant), and 4-nonylphenol (nonionic detergent metabolite). Measured concentrations for this study were generally low and rarely exceeded drinking-water guidelines, drinking-water health advisories, or aquatic-life criteria. Many compounds, however, do not have such guidelines established. The detection of multiple OWCs was common for this study, with a median of seven and as many as 38 OWCs being found in a given water sample. Little is known about the potential interactive effects (such as synergistic or antagonistic toxicity) that may occur from complex mixtures of OWCs in the environment. In addition, results of this study demonstrate the importance of obtaining data on metabolites to fully understand not only the fate and transport of OWCs in the hydrologic system but also their ultimate overall effect on human health and the environment.

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“…Studies that rely on data with multiple variables offer an opportunity for multiple simultaneous hypothesis testing, which may increase efficiency, but presents a challenge with respect to proper interpretation of results. For example, data from in vitro assays and results of in vivo animal studies appear to be in disagreement on whether or not TCS is expected to exert androgenic or anti-androgenic activity (Foran et al 2000;Chen et al 2007;Kumar et al 2009;Witorsch 2014). Without strong a priori evidence, it may be reasonable to examine two competing hypotheses: (1) higher levels of TCS exposure are associated with higher levels of testosterone in humans and (2) TCS exposure is inversely related to testosterone concentrations.…”

Section: Consistency Of Methods Results and Reporting Across Studiesmentioning

confidence: 99%

Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

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Developmental evaluation of a potential non-steroidal estrogen: triclosan

Cited by 192 publications

References 4 publications

Effects of the Herbicide Pendimethalin on Hormone Receptor Expressions and Dorsal Fin Biometrics in Thai Medaka, <I>Oryzias Minutillus</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Effects of the Herbicide Pendimethalin on Hormone Receptor Expressions and Dorsal Fin Biometrics in Thai Medaka, <I>Oryzias Minutillus</I> (Actinopterygii: Beloniformes: Adrianichthyidae)

Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance

Systematic review of the literature on triclosan and health outcomes in humans

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