Developmental exposure to environmentally relevant doses of phthalates alters the neural control of male and female reproduction in mice

Adam, Nolwenn; Desroziers, Elodie; Hanine, Rita; Bascarane, Karouna; Naulé, Lydie; Mhaouty-Kodja, Sakina

doi:10.1016/j.envres.2024.119476

Environmental Research

2024

DOI: 10.1016/j.envres.2024.119476

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Developmental exposure to environmentally relevant doses of phthalates alters the neural control of male and female reproduction in mice

Nolwenn Adam,

Elodie Desroziers,

Rita Hanine

et al.

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2024

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Effects of minipuberty disruption on the expression of sexual behavior in female mice

Torres,

Parmentier,

Guigon

et al. 2024

Sci Rep

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Sex steroids influence early organization of neural structures involved in expression of sexual behavior. A critical perinatal period during which testosterone surges occur has been identified in male rodents. Data are lacking for females, whose ovarian activity starts later in the postnatal period. Minipuberty has been described in female as a first postnatal period of gonadotropic axis activation. We transiently disrupted the minipubertal period, using daily injections of GnRH antagonist or aromatase inhibitor. The results showed unchanged puberty initiation and mild disturbance of estrus cyclicity. Minor modifications of some components of sexual behavior (olfactory preference, ability to attract male) were observed, but had no impact on lordosis behavior. Interestingly, letrozole-treated female mice showed increased anxiety state level at adulthood. This period therefore does not seem to be a key organizational window for female sexual behavior but appears to participate in the organization of neural structures involved in anxiety-related behavior.

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Effects of minipuberty disruption on the expression of sexual behavior in female mice

Torres,

Parmentier,

Guigon

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Developmental exposure to environmentally relevant doses of phthalates alters the neural control of male and female reproduction in mice

Cited by 1 publication

References 47 publications

Effects of minipuberty disruption on the expression of sexual behavior in female mice

Effects of minipuberty disruption on the expression of sexual behavior in female mice

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