2015
DOI: 10.1016/j.aquatox.2015.01.014
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Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish

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Cited by 146 publications
(72 citation statements)
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References 57 publications
(68 reference statements)
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“…Toxicological data suggest that TDCIPP and TPHP are reproductive toxins [28, 29] and have carcinogenic [30], neurotoxic [3133] and endocrine-disrupting properties [3439]. Currently, available data are very limited on human exposure [10, 11, 4042] and data on potential human health effects are lacking.…”
Section: Introductionmentioning
confidence: 99%
“…Toxicological data suggest that TDCIPP and TPHP are reproductive toxins [28, 29] and have carcinogenic [30], neurotoxic [3133] and endocrine-disrupting properties [3439]. Currently, available data are very limited on human exposure [10, 11, 4042] and data on potential human health effects are lacking.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, in this study, it was observed that exposures to EE 2 and Fad interfere with the cell proliferation balance in zebrafish gonad. In general, EE 2 (Luzio et al, 2015b(Luzio et al, , 2016a and other xenoestrogens (Tokumoto et al, 2004(Tokumoto et al, , 2005Wang et al, 2015c) have been pointed to as promoters of zebrafish gonad development, corroborating the slight tendency of JUN to increase in all types of gonads exposed to EE 2 . Since JUN is involved in ovarian differentiation and development, the increase of the relative volumes of this protein in response to EE 2 reinforces the fact that estrogens have a crucial role in female development (Fenske and Segner, 2004;Guiguen et al, 2010;Luzio et al, 2015bLuzio et al, , 2016a.…”
Section: Tablementioning
confidence: 81%
“…It was shown that TDCPP exposure caused developmental toxicity in zebrafish, including decreasing the hatching and survival rates, body weight and length, and increasing malformation rates. Long‐term exposure disturbed the endocrine, decreased the production of eggs, and further reduced the fecundity of zebrafish (Liu et al , ; Wang et al ; Dishaw et al ; Zhu et al ; Wang et al ). Furthermore, TDCPP exposure reduced chicken embryo mass and growth parameters (Farhat et al ).…”
Section: Discussionmentioning
confidence: 99%