Developmental Expression of Steroidogenic Factor 1 in a Turtle with Temperature-Dependent Sex Determination

Fleming, Alice; Wibbels, Thane; Skipper, James K.; Crews, David

doi:10.1006/gcen.1999.7360

Cited by 50 publications

(53 citation statements)

References 45 publications

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“…Previous research indicates that SF-1 play an important role in mammalian ventromedial nucleus development (Roselli et al, 1997;Fleming et al, 1999;Dellovade et al, 2000) and regulation of GTH expression in pituitary Ahmed, 1998;Bakke et al, 2001). We analyzed five regions of the carp brain including telecephalon, midbrain, cerebellum, and medulla oblongata, and found that SF-1 was expressed in the hypothalamus of both sexes (Fig.…”

Section: Discussionmentioning

confidence: 89%

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Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Tang

Hao

et al. 2010

General and Comparative Endocrinology

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Section: Discussionmentioning

confidence: 89%

“…The gonadotropes of SF-1 knockout mice lack a number of genes that regulate reproduction, hormones (GTH-a) and GnRH receptor . SF-1 is also important for testis differentiation, as it has been found to be highly expressed in developing testes of mice and slider turtles (Trachemys scripta) Fleming et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Tang

Hao

et al. 2010

General and Comparative Endocrinology

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“…Sf1 expression patterns in developing gonads have been investigated in two TSD reptiles, the alligator and the red-eared slider turtle (Fleming et al 1999). Results of these two reports both demonstrate sexually dimorphic expression of Sf1 early in the TSP, during gonadal differentiation, but they document opposite patterns of expression.…”

Section: P K Elfmentioning

confidence: 99%

Temperature-Dependent Sex Determination in Vertebrates

Valenzuela¹,

Lance²

2018

Open Monographs

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“…Dmrt1 also is critical to sex determination, as its expression is detected in both Sertoli cells and PGCs (Raymond et al, 1998(Raymond et al, , 1999. Finally, the temporal and spatial expression patterns of Sf1 in the gonad are conserved between turtle and mouse Fleming et al, 1999;Luo et al, 1994).…”

Section: Case Study: Sex Determination and Gonadal Differentiationmentioning

confidence: 99%

From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior

et al. 2006

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Genes are not expressed in isolation any more than social behavior has meaning outside of society. Both are in dynamic flux with the immediate environment that the gene/individual finds itself, which in turn establishes the timing, pattern, and conditions of expression. This means that complex behaviors and their genetic underpinnings should be viewed as a cumulative process, or as the result of experiences up to that point in time and, at the same time, as setting the stage for what will follow. The evidence indicates that as experiences accumulate throughout life, early experiences shape how genes/individuals will respond to later experiences, whereas later experiences modify the effects of these earlier experiences. A method of graphically representing and analyzing change in gene and neural networks is presented. Results from several animal model systems will be described to illustrate these methods. First, we will consider the phenomenon of temperature-dependent sex determination in reptiles. We will illustrate how the experience of a particular temperature during a sensitive period of embryogenesis sculpts not only the patterns of expression of genes involved in sex determination and gonadal differentiation but also the morphological, physiological, neuroendocrine, and behavioral traits of the adult phenotype. The second model system concerns the effects of the sex ratio in the litter in rats, and the genotype ratio in the litter of transgenic mice, on the nature and frequency of maternal care and how this in turn influences the patterns of activation of identified neural circuits subserving the offspring's sociosexual behavior when it is an adult.

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Developmental Expression of Steroidogenic Factor 1 in a Turtle with Temperature-Dependent Sex Determination

Cited by 50 publications

References 45 publications

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)

Temperature-Dependent Sex Determination in Vertebrates

From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior

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