Developmental expression of the N-myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis

Zhong, Chao; Zhou, Yang; Yang, Shanshan; Zhao, Junfang; Zhu, Xiaolong; Chen, hen-Huang; Chen, Peichao; Huang, Liquan; Huang, Xiao

doi:10.1387/ijdb.150178xh

Cited by 11 publications

(26 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spatial expression pattern of the NDRG family in the CNS was also observed in Xenopus tropicalis [1]. NDRG1 expression was mostly found in the forebrain, which later develops into the cerebrum, whereas NDRG2, NDRG3, and NDRG4 expressions were found in the developing brain and spinal cord.…”

Section: Expression During Developmentmentioning

confidence: 65%

“…Besides the role of NDRG4 in colorectal cancer, NDRG4 and the other NDRGs have also been described to be involved in nervous system cancers, like meningioma, neuroblastoma, and glioma. Moreover, all NDRG genes are expressed in nervous system structures and seem to be involved in the development and physiology of the nervous system [1]. All this addresses a potential importance for the NDRGs in the central and peripheral nervous system.…”

Section: Introductionmentioning

confidence: 97%

“…The name of this family originates from the first gene discovered, NDRG1, as this gene can be repressed by the cmyc and N-Myc proto-oncogenes. However, even though each family member has been given a similar name, they are not all (in)directly regulated by either c-or N-myc [1,2]. NDRG proteins share 57-65% amino acid identity and they all have an α/β hydrolase-fold region without hydrolytic catalytic activity [2,3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

et al. 2019

View full text Add to dashboard Cite

The N-Myc downstream-regulated gene (NDRG) family consists of four members (NDRG1, NDRG2, NDRG3, NDRG4) that are differentially expressed in various organs and function in important processes, like cell proliferation and differentiation. In the last couple of decades, interest in this family has risen due to its connection with several disorders of the nervous system including Charcot-Marie-Tooth disease and dementia, as well as nervous system cancers. By combining a literature review with in silico data analysis of publicly available datasets, such as the Mouse Brain Atlas, BrainSpan, the Genotype-Tissue Expression (GTEx) project, and Gene Expression Omnibus (GEO) datasets, this review summarizes the expression and functions of the NDRG family in the healthy and diseased nervous system. We here show that the NDRGs have a differential, relatively cell typespecific, expression pattern in the nervous system. Even though NDRGs share functionalities, like a role in vesicle trafficking, stress response, and neurite outgrowth, other functionalities seem to be unique to a specific member, e.g., the role of NDRG1 in myelination. Furthermore, mutations, phosphorylation, or changes in expression of NDRGs are related to nervous system diseases, including peripheral neuropathy and different forms of dementia. Moreover, NDRG1, NDRG2, and NDRG4 are all involved in cancers of the nervous system, such as glioma, neuroblastoma, or meningioma. All in all, our review elucidates that although the NDRGs belong to the same gene family and share some functional features, they should be considered unique in their expression patterns and functional importance for nervous system development and neuronal diseases.

show abstract

Section: Expression During Developmentmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

et al. 2019

View full text Add to dashboard Cite

show abstract

“…from single cell creatures to multicellular creatures, and from aquatic creatures and amphibian to terrestrial mammals [ Figure 3]. Furthermore, some evolutionarily conserved molecular networks such as HOX, Hedgehog, and Myc play important roles in the developmental process [66][67][68][69][70][71][72] , indicating development and evolution share some inherent mechanisms. During the past 20 years, the discovery of conserved gene networks that control embryonic development and the ability to examine genomic records has revolutionized Darwinian evolutionism that animal relationships had to be deduced by observation of external morphological characteristics.…”

Section: Development and Evolution (Dev-evo) A Novel Hypothesis Relamentioning

confidence: 99%

Cancer Evo-Dev, a novel hypothesis derived from studies on hepatitis B virus-induced carcinogenesis

Cao¹

2017

View full text Add to dashboard Cite

How to cite this article: Cao GW. Cancer Evo-Dev, a novel hypothesis derived from studies on hepatitis B virus-induced carcinogenesis. Hepatoma Res 2017;3:241-59.Non-resolving inflammation, which may be maintained by infection, pollution, and metabolic stimulants and their interactions with immunogenetic predisposition, provides a fertile field for cancer development. This is strongly evident in hepatocellular carcinoma. Here, the framework of a hypothesis called Cancer Evo-Dev is presented, based on the advances in hepatitis B virusinduced hepatocarcinogenesis. Several aspects central to this theory are as follows: (1) immune imbalance caused by the interaction of immunogenetic predispositions and hepatitis B virus infection maintains non-resolving inflammation; (2) active inflammation executants promote mutations in viral and host genomes via disbalancing mutagenic forces including cytidine deaminases and mutation-repairing forces including uracil-DNA glycosylases, thus promoting cancer-related somatic mutations and viral mutations; (3) a small percentage of the cells whose somatic mutations alter the survival signalling adapt to the inflammatory microenvironment, de-differentiate via demethylating role of cytidine deaminases, and reversely develop into tumor-initiating cells (TICs); (4) under the cultivation of some factors like POSTN from tumorinfiltrating fibroblasts and M2 macrophages, TICs acquire the stemness, cancer-stem cells obtain distinct metastatic and drug-resistant potentials under the selection pressure from distinct microenvironments; (5) glycolysis persistence in the presence of oxygen provides essential energy for cell survival and the raw material for DNA synthesis. Thus, cancer development is characterized by an evolutionary process of "mutation-selection-adaptation". The framework of Cancer Evo-Dev can be verified in other cancers. Cancer Evo-Dev lays theoretical foundation for understanding the mechanisms by which inflammation promotes cancer development, and it also plays a role in specific prophylaxis, prediction, and targeted treatment of cancers. Key words:Inflammation, hepatitis B virus, mutations, hepatoma, Cancer Evo-Dev ABSTRACTArticle history:

show abstract

“…Previous reports have suggested the involvement of the NDRG family in the early life development such as organ formation25262728, somite differentiation29. The multiple expression of NDRG3 in human tissues and organs, with the highest expression in testis2330 is suggesting the presence of some important function of NDRG3 physiologically, especially in testis.…”

mentioning

confidence: 95%

Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells

Pan

Zhang

Jiang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The N-myc downstream regulated gene (NDRG) family consists of 4 members, NDRG-1, -2, -3, -4. Physiologically, we found Ndrg3, a critical gene which led to homologous lethality in the early embryo development, regulated the male meiosis in mouse. The expression of Ndrg3 was enhanced specifically in germ cells, and reached its peak level in the pachytene stage spermatocyte. Haplo-insufficiency of Ndrg3 gene led to sub-infertility during the male early maturation. In the Ndrg3+/− germ cells, some meiosis events such as DSB repair and synaptonemal complex formation were impaired. Disturbances on meiotic prophase progression and spermatogenesis were observed. In mechanism, the attenuation of pERK1/2 signaling was detected in the heterozygous testis. With our primary spermatocyte culture system, we found that lactate promoted DSB repair via ERK1/2 signaling in the male mouse germ cells in vitro. Deficiency of Ndrg3 gene attenuated the activation of ERK which further led to the aberrancy of DSB repair in the male germ cells in mouse. Taken together, we reported that Ndrg3 gene modulated the lactate induced ERK pathway to facilitate DSB repair in male germ cells, which further regulated meiosis and subsequently fertility in male mouse.

show abstract

Developmental expression of the N-myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis

Cited by 11 publications

References 17 publications

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous system

Cancer Evo-Dev, a novel hypothesis derived from studies on hepatitis B virus-induced carcinogenesis

Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells

Contact Info

Product

Resources

About