Developmental immunotoxicity and its potential gender differences of perinatal exposure to 4-nonylphenol on offspring rats: JAK-STAT signaling pathway involved

Xiang, Rong; Yan, Jiuming; Cheng, Shupin; Yang, Yi; Wang, He; Xie, Jun; Zhang, Lishi; Chen, Jinyao

doi:10.1016/j.ecoenv.2022.113560

Cited by 3 publications

(2 citation statements)

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“…However, a growing body of literature indicates that the developing immune system is more vulnerable to toxicant exposure than the adult immune system. 26,[44][45][46][47][48] Epidemiological investigations and animal experiments have consistently concluded that the adverse effects of exogenous chemicals on the developing immune system can last longer or occur at lower doses than that on the adult immune system. [28][29][30]49 More importantly, existing knowledge has established the linkage between early-life immune dysfunction and the incidence of specific diseases such as asthma, allergic disease, and autoimmunity.…”

Section: Discussionmentioning

confidence: 99%

“…Developmental immunotoxicology is a relatively neglected area in regulatory toxicity testing. However, a growing body of literature indicates that the developing immune system is more vulnerable to toxicant exposure than the adult immune system 26,44–48 . Epidemiological investigations and animal experiments have consistently concluded that the adverse effects of exogenous chemicals on the developing immune system can last longer or occur at lower doses than that on the adult immune system 28–30,49 .…”

Section: Discussionmentioning

confidence: 99%

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Developmental immunotoxicity of maternal exposure to yttrium nitrate on BALB/c offspring mice

Yuan

Wang

et al. 2023

Environmental Toxicology

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Yttrium is a typical heavy rare earth element with widespread use in numerous sectors. Only one previous study has indicated that yttrium has the potential to cause developmental immunotoxicity (DIT). Therefore, there remains a paucity of evidence on the DIT of yttrium. This study aimed to explore the DIT of yttrium nitrate (YN) and the self‐recovery of YN‐induced DIT. Dams were treated with 0, 0.2, 2, and 20 mg/kg bw/day YN by gavage during gestation and lactation. No significant changes were found in innate immunity between the control and YN‐treated groups in offspring. In female offspring at postnatal day 21 (PND21), YN markedly inhibited humoral and cellular immune responses, the proliferative capacity of splenic T lymphocytes, and the expression of costimulatory molecules in splenic lymphocytes. Moreover, the inhibitory effect on cellular immunity in female offspring persisted to PND42. Unlike females, YN exposure did not change the adaptive immune responses in male offspring. Overall, maternal exposure to YN showed a strong DIT to offspring, with the lowest effective dose of 0.2 mg/kg in the current study. The toxicity of cellular immunity could persist throughout development into adulthood. There were sex‐specific differences in YN‐induced DIT, with females being more vulnerable.

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