Developmental influences on stress response systems: Implications for psychopathology vulnerability in adolescence

Roberts, Andrea; Lopez-Duran, Nestor L.

doi:10.1016/j.comppsych.2018.10.008

Cited by 75 publications

(45 citation statements)

References 224 publications

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“…More recent work illustrates that HRV is a reliable indicator of stress in young children (5–10 years of age), such that greater peer problems, anger, anxiety, and sadness are associated with lower HRV (Michels et al, 2013). Similar to work on the hypothalamus‐pituitary‐adrenal axis (Roberts & Lopez‐Duran, 2019), it is suggested that early developmental influences and the caregiving environment (e.g. Calkins, Graziano, Berdan, Keane, & Degnan, 2008) may result in altered ANS functioning during adolescence (absence of normative increase in vagal activity) leading to heightened sensitivity to stressors and increased risk for psychopathology.…”

Section: A Dynamical Model Of Neurovisceral Integrationmentioning

confidence: 82%

Neurovisceral regulatory circuits of affective resilience in youth

Koenig

2020

Psychophysiology

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The Neurovisceral Integration Model (NIM) is one of the most influential psychophysiological models addressing the interplay between the autonomic (ANS) and central nervous system (CNS). In their groundbreaking conceptual work, integrating autonomic, attentional, and affective systems into a functional and structural network, Thayer & Lane laid the foundation for empirical research in the past two decades. The present paper provides a principal outline aiming to reflect and further elaborate on the model from a dynamic developmental perspective. The central question at hand is, how does neurovisceral integration develop (early in life)? By reviewing the existing evidence, it is illustrated that key components of the model, both, on a physiological and psychological level, undergo extensive change early in the course of life. This sensitive period of human development seems key for our understanding of the integrated action of the ANS and CNS in emotion across the lifespan. Early life events may interfere with the fine-tuned interplay of this shared neural circuitry resulting in long-term dysfunction and psychiatric illness. In the absence of longitudinal data covering the entire co-development of the ANS and CNSfrom early childhood to adolescence into early adulthood, it is suggested, that vagal activity and its normative increase in adolescence is a key premise for normative brain development on a structural and functional level, subsequent psychological functioning and adaptive regulation. Implications from this dynamic perspective and suggestions for future research in the field of developmental psychophysiology are discussed. K E Y W O R D Sadolescence, brain development, emotion regulation, heart rate variability, neurovisceral integration, psychopathology 2 of 18 | KOENIG

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Section: A Dynamical Model Of Neurovisceral Integrationmentioning

confidence: 82%

Neurovisceral regulatory circuits of affective resilience in youth

Koenig

2020

Psychophysiology

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“…57 The discrepancy in these studies may be related to the differences in the age of animals when experiencing stress and the stress paradigms employed. 58,59 Recently, the underlying biological and neurobiological mechanisms mediating the effect of childhood and adolescent adversities on psychopathology vulnerability have been scrutinized. Some of the persistent biological alterations were associated with childhood and adolescent adversities, such as changes in neuroendocrine, neurotransmitter systems and immune system.…”

Section: Discussionmentioning

confidence: 99%

The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice

Zeman

et al. 2020

NDT

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Objective: Adverse childhood and adolescent experiences are associated with the emergences of psychopathology later in life and have negative consequences on white matter integrity. However, this adversity-induced white matter impairment remains not fully investigated. Methods: Adolescent Balb/c mice were subjected to intermittent social defeat stress once a day during postnatal days 25 to 40. Then, the subjects were allowed to recover for three weeks before sacrifice. At the end, oligodendrocyte (OL) lineage cells, cell proliferation, and microglia activation, as well as myelin basic protein (MBP) levels in frontal cortex and hippocampus were evaluated. The levels of interleukin (IL)-1β and IL-6 in the brain regions were assessed. Results: MBP protein level in frontal cortex, but not in the hippocampus of defeated mice, decreased significantly compared to controls. The numeral densities of mature OLs, oligodendrocyte progenitor cells, and proliferating cells in medial prefrontal cortex were comparable between the defeated mice and controls. The defeated mice, however, showed significantly higher IL-1β level, although IL-6 level and numeral density of microglia in frontal cortex did not change relative to controls. Conclusion: These results indicate that effects of intermittent social defeat stress on the white matter integrity and OL lineage cells in mouse brain are region-and developmental stage-specific. Upregulated IL-1β may contribute to this negative consequence though the underlying mechanism remains to be investigated.

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“…Nonetheless, the hormone DHEA has well-established neuroprotective and antiglucocorticoid effects [7, 8], perhaps reducing the impact of trauma on the HPA axis. These effects may be especially pertinent during the adolescent period, given the influence of development on both neuroendocrine functioning and the development of psychopathology during this time period [9]. It is unknown, however, if high levels of DHEA can attenuate trauma-induced HPA axis changes.…”

Section: Dhea Moderates the Impact Of Childhood Maltreatment On The Hpa Axis In Adolescencementioning

confidence: 99%

DHEA Moderates the Impact of Childhood Trauma on the HPA Axis in Adolescence

et al. 2021

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Background: Trauma can lead to long-term downregulation of the hypothalamic pituitary adrenal (HPA) axis. However, dehydroepiandrosterone (DHEA) has neuroprotective effects that may reduce the need for downregulation of the axis in response to stress. Furthermore, high DHEA/cortisol ratios are often conceptualized as better markers of DHEA’s availability than DHEA alone, as ratios account for the coupling of DHEA and cortisol in response to stress. Objectives: In this study, we explored if DHEA and DHEA/cortisol ratios moderated the association between childhood maltreatment and the HPA axis stress response. Methods: The sample consisted of 101 adolescents (ages 12–16) who completed the Child Trauma Questionnaire (CTQ) and the Trier Social Stress Test (TSST). Cortisol was modeled using saliva samples at 8 time points throughout the TSST. Cortisol and DHEA ratios were examined at baseline and 35 min after stress initiation. Results: Childhood maltreatment was associated with less steep cortisol activation slope and peak cortisol levels, but DHEA and DHEA/cortisol ratios moderated this effect. At high levels of DHEA, the impact of childhood maltreatment on cortisol peak levels was no longer significant. In contrast, high DHEA/cortisol ratios were associated with an intensification of the impact of childhood maltreatment on peak levels. Conclusions: Results suggest that DHEA can limit the blunting of the HPA axis in response to childhood maltreatment. However, this protective effect was not reflected in high DHEA/cortisol ratios as predicted. Therefore, high DHEA and high DHEA/cortisol ratios may reflect different, and potentially opposite, processes.

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Developmental influences on stress response systems: Implications for psychopathology vulnerability in adolescence

Cited by 75 publications

References 224 publications

Neurovisceral regulatory circuits of affective resilience in youth

Neurovisceral regulatory circuits of affective resilience in youth

<p>The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice</p>

DHEA Moderates the Impact of Childhood Trauma on the HPA Axis in Adolescence

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