Developmental innervation of cranial dura mater and migraine headache: A narrative literature review

Witten, Andrew J.; Marotta, Dario A; Cohen-Gadol, Aaron

doi:10.1111/head.14102

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…The dura mater, its vasculature supply, and the cerebral blood vessels are the only structures containing nociceptive nerve fibers [ 31 ]. The role of dura mater in migraine pain was widely examined.…”

Section: Dura Mater In Migrainementioning

confidence: 99%

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

et al. 2021

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Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing headache, which lasts for hours to days, and the pain can interfere with daily activities. It exhibits various symptoms, such as nausea, vomiting, sensitivity to light, sound, and odors, and physical activity consistently contributes to worsening pain. Despite the intensive research, little is still known about the pathomechanism of migraine. It is widely accepted that migraine involves activation and sensitization of the trigeminovascular system. It leads to the release of several pro-inflammatory neuropeptides and neurotransmitters and causes a cascade of inflammatory tissue responses, including vasodilation, plasma extravasation secondary to capillary leakage, edema, and mast cell degranulation. Convincing evidence obtained in rodent models suggests that neurogenic inflammation is assumed to contribute to the development of a migraine attack. Chemical stimulation of the dura mater triggers activation and sensitization of the trigeminal system and causes numerous molecular and behavioral changes; therefore, this is a relevant animal model of acute migraine. This narrative review discusses the emerging evidence supporting the involvement of neurogenic inflammation and neuropeptides in the pathophysiology of migraine, presenting the most recent advances in preclinical research and the novel therapeutic approaches to the disease.

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Section: Dura Mater In Migrainementioning

confidence: 99%

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

et al. 2021

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“…The meninges are highly innervated by various nerve fibers, involving sympathetic and parasympathetic nerves, as well as sensory fibers ( 50 – 53 ). Many pioneers have contributed to the description of the meningeal innervation, revealing that there are significant differences in innervation between the pachymeninx and the leptomeninx of the cranial cavity and spine ( 4 , 54 ).…”

Section: Meningeal Immune Systemmentioning

confidence: 99%

New insight into DAVF pathology—Clues from meningeal immunity

Peng

Song

et al. 2022

Front. Immunol.

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In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape. The latest concept of meningeal immune system is a tertiary structure, which is a comprehensive overview of the meningeal immune system from macro to micro. We comprehensively reviewed recent advances in meningeal immunity, particularly the new understanding of the dural sinus and meningeal lymphatics. Moreover, based on the clues from the meningeal immunity, new insights were proposed into the dural arteriovenous fistula (DAVF) pathology, aiming to provide novel ideas for DAVF understanding.

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“…This differentiation also reflects the intracranial anatomy: the supratentorial dura mater is primarily innervated by the V1 branch of the trigeminal nerve, which is the same branch responsible for “pain in the face” above the orbitomeatal line. 4 In the clinical practice of pain, these anatomical borders are less relevant, regional pain clearly ignores these borders and “facial pains” spread to the “head” and vice versa.…”

Section: Introductionmentioning

confidence: 99%

A Review of Current Perspectives on Facial Presentations of Primary Headaches

Peng¹,

Benoliel²,

May³

2022

JPR

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Orofacial pain (OFP) has recently been classified and subdivided into a number of groups, similar to headache disorders in the International Classification of Headache Disorders (ICHD). A novel group of OFP has been established whose major feature is that they resemble primary headache disorders occurring in the V2 or V3 dermatomes. These follow the clinical criteria and associated symptoms of the eponymous headache syndromes. Following the recent International Classification of Orofacial Pain (ICOP), three types are differentiated: Headache which spread into the face (type 1), facial pain which replaced headache but maintained the same characteristics and associated symptoms of the former headache (type 2), and de-novo orofacial pain that resembles primary headache types without any involvement of the ophthalmic trigeminal branch (type 3). The epidemiology is unclear: type 1 and 2 are not exactly common, they certainly exist in a notable proportion of headache patients, whereas type 3 may be rather rare. Since effective treatment options are available, it is important for clinicians to recognize such syndromes early to avoid misdiagnosis and unnecessary treatment, which most of these patients still experience. This review gives an up-to-date summary of diagnosis, pathophysiology and treatment of attack-like non-dental facial pain disorders.

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Developmental innervation of cranial dura mater and migraine headache: A narrative literature review

Cited by 8 publications

References 43 publications

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research

New insight into DAVF pathology—Clues from meningeal immunity

A Review of Current Perspectives on Facial Presentations of Primary Headaches

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