Developmental language disability as a consequence of prenatal exposure to ethanol

Shaywitz, Sally E.; Caparulo, Barbara K.; Hodgson, Elizabeth Susan

doi:10.1016/s0002-7138(09)60906-7

Cited by 11 publications

(22 citation statements)

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“…A casecontrol study of attention-deficit hyperactivity disorder (ADHD) showed cases were 2.5 times more likely to have been exposed to alcohol in utero independently of association with prenatal exposure to nicotine and other drugs (Mick et al, 2002). Learning difficulties, most notably in mathematics and language, are evident even when documentable mental retardation is not, suggesting the hippocampus and neocortex are particularly sensitive areas of the brain (Coles et al, 1991;Kopera-Frye et al, 1996;Shaywitz et al, 1980Shaywitz et al, , 1981.…”

Section: Introductionmentioning

confidence: 99%

Computational models of ethanol‐induced neurodevelopmental toxicity across species: Implications for risk assessment

Gohlke

Griffith

Faustman

2007

Birth Defects Research Pt B

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Computational, systems-based approaches can provide a quantitative construct for evaluating risk in the context of mechanistic data. Previously, we developed computational models for the rat, mouse, rhesus monkey, and human, describing the acquisition of adult neuron number in the neocortex during the key neurodevelopmental processes of neurogenesis and synaptogenesis. Here we apply mechanistic data from the rat describing ethanol-induced toxicity in the developing neocortex to evaluate the utility of these models for analyzing neurodevelopmental toxicity across species. Our model can explain long-term neocortical neuronal loss in the rodent model after in utero exposure to ethanol based on inhibition of proliferation during neurogenesis. Our human model predicts a significant neuronal deficit after daily peak BECs reaching 10-20 mg/dl, which is the approximate BEC reached after drinking one standard drink within one hour. In contrast, peak daily BECs of 100 mg/dl are necessary to predict similar deficits in the rat. Our model prediction of increased sensitivity of primate species to ethanol-induced inhibition of proliferation is based on application of in vivo experimental data from primates showing a prolonged rapid growth period in the primate versus rodent neuronal progenitor population. To place our predictions into a broader context, we evaluate the evidence for functional low-dose effects across rats, monkeys, and humans. Results from this critical evaluation suggest subtle effects are evident at doses causing peak BECs of approximately 20 mg/dl daily, corroborating our model predictions. Our example highlights the utility of a systems-based modeling approach in risk assessment. Birth Defects Res (Part B) 83: 1-11, 2008.

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Section: Introductionmentioning

confidence: 99%

Computational models of ethanol‐induced neurodevelopmental toxicity across species: Implications for risk assessment

Gohlke

Griffith

Faustman

2007

Birth Defects Research Pt B

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“…This fact was also described in a prior study 33 . Studies with cases made up of younger individuals tend to report less-compromised clinical pictures than those with school-aged individuals 16,18 . However, the use of development scales has allowed researchers to identify delays of, at least, six months by individuals with FASD compared with their peers of the same chronological age and who have not been exposed to alcohol during pregnancy 16,18,20,21,33,34 .…”

Section: Figure 2-synthesis Of Compiled Articles On Spoken Language Imentioning

confidence: 99%

“…Studies with cases made up of younger individuals tend to report less-compromised clinical pictures than those with school-aged individuals 16,18 . However, the use of development scales has allowed researchers to identify delays of, at least, six months by individuals with FASD compared with their peers of the same chronological age and who have not been exposed to alcohol during pregnancy 16,18,20,21,33,34 . One aspect that must be considered when proposing a design for a study in the area of spoken language, including individuals in preschool age, is the relatively lower number of instruments available for this assessment, when compared with the instruments available for school-aged population.…”

Section: Figure 2-synthesis Of Compiled Articles On Spoken Language Imentioning

confidence: 99%

“…The age heterogeneity and the diversification of instruments used in the studies presented are some of the factors that make it difficult to carry out a comparative analysis of these studies, mainly with regard to chronological age and intellectual Through a historical and evolutional perspective of the 21 studies carried out in the area of spoken language in FASD, we note that the first publication dates to 1981 18 , 13 years after FASD was acknowledged by the scientific community. Approximately ten years after this first publication, which reported two brothers with FASD presenting significant impaired language acquisition, a study 19 was published -extending the number of FASD cases and also adopting the case-control method -, and compared the performance of individuals with FASD with individuals of the same chronological and mental age with typical language development.…”

Section: Figure 2-synthesis Of Compiled Articles On Spoken Language Imentioning

confidence: 99%

“…The survey showed that the scientific production in the field of spoken language on FASD was predominantly from the United States (57.15% of studies), although it was little representative 16,18,[20][21][22][23][24][25][26] . We note that out of the 21 studies selected for this review, only 3 27-29 presented data of Brazil, in spite of the country's increase in alcohol consumption by pregnant women.…”

Section: Figure 2-synthesis Of Compiled Articles On Spoken Language Imentioning

confidence: 99%

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Linguagem no transtorno do espectro alcoólico fetal: uma revisão

2015

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O Transtorno do Espectro Alcoólico Fetal é uma condição clínica que vem despertando o interesse de diferentes pesquisadores por ser considerada relativamente frequente na população, com incidência de aproximadamente 10 casos a cada 1000 nascimentos. As alterações neurodesenvolvimentais que caracterizam o fenótipo desta condição são descritas pela presença de prejuízos de memória, de atenção, da habilidade visuo-espacial, das funções executivas, de aprendizagem, bem como do comprometimento na linguagem falada. Considerando os prejuízos da linguagem que permeiam o Espectro Alcoólico Fetal, este trabalho propõe-se a realizar uma revisão da literatura para identificar quais os procedimentos e achados reportados na área da linguagem para essa condição clínica. Os 21 artigos selecionados nesta revisão refletem uma variabilidade na metodologia empregada e distintos procedimentos de avaliação da linguagem falada. O perfil da linguagem falada dos indivíduos com diagnóstico de Transtorno do Espectro Alcoólico Fetal caracteriza-se por diferentes desempenhos na linguagem falada e com grau de comprometimento variável. Diversos fatores influenciam na variabilidade de comprometimento da linguagem falada descrito no Transtorno do Espectro Alcoólico Fetal, sendo que a quantidade de álcool ingerida, o período de gestação em que ocorreu o consumo e a susceptibilidade individual do feto ao metabolizar o álcool no organismo são frequentemente descritos.

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