2016
DOI: 10.1002/dneu.22380
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Developmental nicotine exposure alters cholinergic control of respiratory frequency in neonatal rats

Abstract: Prenatal nicotine exposure with continued exposure through breast milk over the first week of life (developmental nicotine exposure, DNE) alters the development of brainstem circuits that control breathing. Here, we test the hypothesis that DNE alters the respiratory motor response to endogenous and exogenous acetylcholine (ACh) in neonatal rats. We used the brainstem-spinal cord preparation in the split-bath configuration, and applied drugs to the brainstem compartment while measuring the frequency and amplit… Show more

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Cited by 8 publications
(3 citation statements)
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References 67 publications
(95 reference statements)
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“…Finally, it is interesting that the frequency of rhythmic motoneuron bursting was not altered by DNE, though there was a trend towards a higher frequency in XIIMNs from DNE animals (Fig. 3), as observed previously (Wollman et al, 2016), consistent with elevated excitability. It is clear that additional studies are necessary to elucidate the precise mechanisms underlying this form of DNE-induced plasticity in the neural networks that control the structure and function of XIIMNs, as well as the functional consequences of these developmental alterations.…”
Section: Discussionsupporting
confidence: 85%
“…Finally, it is interesting that the frequency of rhythmic motoneuron bursting was not altered by DNE, though there was a trend towards a higher frequency in XIIMNs from DNE animals (Fig. 3), as observed previously (Wollman et al, 2016), consistent with elevated excitability. It is clear that additional studies are necessary to elucidate the precise mechanisms underlying this form of DNE-induced plasticity in the neural networks that control the structure and function of XIIMNs, as well as the functional consequences of these developmental alterations.…”
Section: Discussionsupporting
confidence: 85%
“…It is well known that stimulation of nAChRs on glutamatergic neurons leads to increased release of glutamate (Wonnacott et al, 1990; Wonnacott, 1997; Gentry and Lukas, 2002). Importantly, chronic nicotine exposure is associated with both an upregulation and long-term desnensitization of nAChRs in many neuron types (Wonnacott, 1990; Gentry and Lukas, 2002), including XIIMNs (Pilarski et al, 2012; Wollman et al, 2016). Accordingly, we also studied glutamatergic synaptic transmission while nAChRs were activated with an acute nicotine challenge.…”
Section: Discussionmentioning
confidence: 99%
“…Using techniques described previously (Fregosi et al, 2004;Wollman et al, 2016), neonatal rats were anesthetized with hypothermia, and the brain stem and spinal cord, extending from the pontomedullary junction to below the upper thoracic nerve roots, were removed en bloc. The preparation was used in the split bath configuration (Figures 1 and 6) and breathing-related motor output was recorded from C4 ventral roots (C4VR).…”
Section: Brainstem-spinal Cord Preparationmentioning
confidence: 99%