Developmental oestrogen exposure differentially modulates IGF-I and TNF-α expression levels in immune organs of Yersinia ruckeri-challenged young adult rainbow trout (Oncorhynchus mykiss)

Wenger, Michael; Shved, Natallia; Akgül, Gülfirde; Caelers, Antje; Casanova, Ayako; Segner, Helmut; Eppler, Elisabeth

doi:10.1016/j.ygcen.2014.05.022

Cited by 19 publications

(21 citation statements)

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“…These changes of immune gene transcript levels were associated with increased susceptibility of rainbow trout to pathogen infection (Vibrio anguillarum), with both NP and atrazine. Similar results were found for E2 in combination with the pathogen Yersinia ruckeri in the study of Wenger et al (2014). And a number of microarray studies which were not aiming to assess immunotoxicity also found that immune-related genes and pathways were significantly affected by the toxic exposure (Krasnov et al 2005;Williams et al 2008;Leaver et al 2010) -indicating again the sensitivity of immune parameters to toxicants.…”

Section: Lysozyme Activity (7%)supporting

confidence: 70%

20 Years of fish immunotoxicology – what we know and where we are

Rehberger

Werner

Hitzfeld

et al. 2017

Critical Reviews in Toxicology

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Despite frequent field observations of impaired immune response and increased disease incidence in contaminant-exposed wildlife populations, immunotoxic effects are rarely considered in ecotoxicological risk assessment. The aim of this study was to review the literature on immunotoxic effects of chemicals in fish to quantitatively evaluate (i) which experimental approaches were used to assess immunotoxic effects, (ii) whether immune markers exist to screen for potential immunotoxic activities of chemicals, and (iii) how predictive those parameters are for adverse alterations of fish immunocompetence and disease resistance. A total of 241 publications on fish immunotoxicity were quantitatively analyzed. The main conclusions included: (i) To date, fish immunotoxicology focused mainly on innate immune responses and immunosuppressive effects. (ii) In numerous studies, the experimental conditions are poorly documented, as for instance age or sex of the fish or the rationale for the selected exposure conditions is often missing. (iii) Although a broad variety of parameters were used to assess immunotoxicity, the rationale for the choice of measured parameters was often not given, remaining unclear how they link to the suspected immunotoxic mode of action of the chemicals. (iv) At the current state of knowledge, it is impossible to identify a set of immune parameters that could reliably screen for immunotoxic potentials of chemicals. (v) Similarly, in fish immunotoxicology there is insufficient understanding of how and when chemical-induced modulations of molecular/cellular immune changes relate to adverse alterations of fish immunocompetence, although this would be crucial to include immunotoxicity in ecotoxicological risk assessment.

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Section: Lysozyme Activity (7%)supporting

confidence: 70%

20 Years of fish immunotoxicology – what we know and where we are

Rehberger

Werner

Hitzfeld

et al. 2017

Critical Reviews in Toxicology

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“…In addition, in the gilthead sea bream Sparus aurata and the rainbow trout Oncorhynchus mykiss , IGF-I gene was expressed in head kidney [ 41 , 42 , 43 , 44 ]. In situ hybridization of the tilapia head kidney revealed IGF-I mRNA in numerous immune cells [ 42 , 43 , 45 ].…”

Section: Immune Cells Of Fish As Site Of Local Igf Synthesismentioning

confidence: 99%

“…, IGF-I) was tissue and treatment specific [ 44 ]. The results indicate a stimulatory effect of infection on IGF-I and TNF-α gene expression in the spleen: IGF-I was elevated 6.802-fold ( p = 0.0001) at Day 3 after infection with 10 6 colony-forming unit (CFU) of Yersinia ruckeri [ 86 , 87 ] and TNF-α gene expression 60.497-fold ( p = 0.001) as compared with the uninfected control [ 44 ]. The infection reduced the survival rates of the rainbow trout to 61% [ 87 ].…”

Section: Igf-i and Tnf-α During Pathogenic Infection Of Fishmentioning

confidence: 99%

Endocrine and Local IGF-I in the Bony Fish Immune System

Franz

Faass

Köllner

et al. 2016

Biology

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A role for GH and IGF-I in the modulation of the immune system has been under discussion for decades. Generally, GH is considered a stimulator of innate immune parameters in mammals and teleost fish. The stimulatory effects in humans as well as in bony fish often appear to be correlated with elevated endocrine IGF-I (liver-derived), which has also been shown to be suppressed during infection in some studies. Nevertheless, data are still fragmentary. Some studies point to an important role of GH and IGF-I particularly during immune organ development and constitution. Even less is known about the potential relevance of local (autocrine/paracrine) IGF-I within adult and developing immune organs, and the distinct localization of IGF-I in immune cells and tissues of mammals and fish has not been systematically defined. Thus far, IGF-I has been localized in different mammalian immune cell types, particularly macrophages and granulocytes, and in supporting cells, but not in T-lymphocytes. In the present study, we detected IGF-I in phagocytic cells isolated from rainbow trout head kidney and, in contrast to some findings in mammals, in T-cells of a channel catfish cell line. Thus, although numerous analogies among mammals and teleosts exist not only for the GH/IGF-system, but also for the immune system, there are differences that should be further investigated. For instance, it is unclear whether the primarily reported role of GH/IGF-I in the innate immune response is due to the lack of studies focusing on the adaptive immune system, or whether it truly preferentially concerns innate immune parameters. Infectious challenges in combination with GH/IGF-I manipulations are another important topic that has not been sufficiently addressed to date, particularly with respect to developmental and environmental influences on fish growth and health.

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“…Thus, ovary and testis specific insulin-like growth factor (IGF)-3 has been detected in Nile tilapia (Oreochromis niloticus) [52]. Changes in the gene expression of IGFs in immune tissues have been related to the immune response against Yersinia infections and are modified upon E 2 treatment in a tissue-dependent manner [9]. Moreover, in rainbow trout females, interferon (IFN)-3/4 show restricted high expression in the ovary [53,54].…”

Section: Immune Effectors Out Of the Blood-testis Barriermentioning

confidence: 99%

“…As an example, silver seabream (Sparus sarba) specimens suffering a vibriosis outbreak showed an increase in testosterone (T) serum levels as the infection progressed, while estradiol (E 2 ) was found to sharply decrease in moribund fish [8]. Additionally, the exogenous administration of E 2 decreased the survival rates of Yersinia-infected rainbow trout (Oncorhynchus mykiss) in an E 2 -dependent dose-manner [9]. It is clear that hormones such as cortisol, growth hormone (GH), prolactin (PRL), some proopiomelanocortin-derived peptides, and reproductive hormones from all the levels of the neuroendocrine reproductive axis regulate leucocyte functions and different immune responses in several fish species.…”

Section: Introductionmentioning

confidence: 99%

Immune-Endocrine Interactions in the Fish Gonad during Infection: An Open Door to Vertical Transmission

Valero

Cuesta

Cammarata

et al. 2018

Fishes

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Abstract:The interaction between the immune and endocrine systems has long been recognized in vertebrates. In fish, it is known that the prevalence and intensity of such infections are higher in males than in females and probably related to sex steroid hormone levels. In addition, the immune response in the fish gonad tissues is specifically regulated to prevent infertility. This condition is used by some pathogens to colonize the fish gonad, evade the systemic immune response, and so spread to the progeny. This review brings up to date our knowledge concerning fish gonad immunity and its regulation, immune-endocrine interactions, and how some pathogens use this tissue to spread to the progeny through vertical transmission. More specifically, we will look at the case of the European sea bass and nodavirus (NNV). Sea bass is a very susceptible fish species to NNV infections, and this virus has been associated to vertical transmission since it is detected in gonad fluids as well as in testicular gametes. In fact, sea bass immunity in the gonad is regulated in a very different way to other target tissues (brain and retina) or immune-relevant tissues (head-kidney or spleen).

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Developmental oestrogen exposure differentially modulates IGF-I and TNF-α expression levels in immune organs of Yersinia ruckeri-challenged young adult rainbow trout (Oncorhynchus mykiss)

Cited by 19 publications

References 50 publications

20 Years of fish immunotoxicology – what we know and where we are

20 Years of fish immunotoxicology – what we know and where we are

Endocrine and Local IGF-I in the Bony Fish Immune System

Immune-Endocrine Interactions in the Fish Gonad during Infection: An Open Door to Vertical Transmission

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