2021
DOI: 10.1101/2021.06.25.449956
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Developmental onset of a cerebellar-dependent forward model of movement in motor thalamus

Abstract: To execute complex behavior with temporal precision, adult animals use internal models to predict the sensory consequences of self-generated movement. Here, taking advantage of the unique kinematic features of twitches-the brief, discrete movements of active sleep-we captured the developmental onset of a cerebellar-dependent internal model. Using rats at postnatal days (P) 12, P16, and P20, we compared neural activity in two thalamic structures: the ventral posterior (VP) and ventral lateral (VL) nuclei, both … Show more

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