Developmental origins of adult health and disease

Barker, Djp

doi:10.1136/jech.58.2.114

Cited by 390 publications

(271 citation statements)

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“…According to the developmental origin of health and disease hypothesis, 1 this transformation may give rise to a greater risk of chronic diseases due to the mismatch between foetal programming and the subsequent environment. [2][3][4][5][6] Obesity, a potential pandemic, is becoming a serious public health issue in developing and newly developed countries such as Taiwan. Several studies have found that the prevalence of obesity has increased in the Taiwanese population.…”

Section: Introductionmentioning

confidence: 99%

Trends in the association between blood pressure and obesity in a Taiwanese population between 1996 and 2006

Summers

Burley

et al. 2010

J Hum Hypertens

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In the last decades, the prevalence of obesity has increased in the Taiwanese population. This has the potential to impact on the risks of cardiovascular diseases and diabetes. This study investigated trends in the changes in several indices of obesity in the last decade, and the relationship between blood pressure (BP) and these obesity indices available in Mei-Jaw Corporation health-screening data from 1996/1998 to 2006. Three cross-sectional surveys among healthy individuals ages 20-59 years, in which 14 362 subjects examined in year 1996, 17 368 in 1998, and 28 524 in 2006, were included in the analysis. Body weight and height data were available from 1996, whereas %body fat, waist circumference and waist-hip ratio (Whratio) were only available from 1998 onwards. We found that the association between systolic BP and body weight, body mass index, %body fat, Whratio and waist became stronger for both men and women in 2006 than 1996 after adjustment for age, education level, alcohol intake, smoking and betel nut chewing. In contrast, non-obese people seemed to have lower diastolic BP in 2006 than in 1996. This trend is consistent irrespective of the index of obesity used. Among healthy individuals, the average values for the obesity indices increased in men but remained similar in women. However, in both men and women, the relationship between obesity and BP has changed. Further research is required to investigate the impact of these intriguing changes in the associations on the risk of cardiovascular diseases in the Taiwanese population.

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Section: Introductionmentioning

confidence: 99%

Trends in the association between blood pressure and obesity in a Taiwanese population between 1996 and 2006

Summers

Burley

et al. 2010

J Hum Hypertens

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“…Maternal health status can have a direct impact on the risk for childhood obesity and obesity-related comorbidities. 203 Exposure to maternal diabetes mellitus increases an infant's risk of future diabetes and obesity. 204 Infants born small for gestational age are also at increased risk for obesity, diabetes, and hypertension, further suggesting the vulnerability of the child to the intrauterine environment, 205,206 although postnatal parenting factors may also play a role.…”

Section: Prenatal Environmentmentioning

confidence: 99%

Recommendations for Prevention of Childhood Obesity

Davis¹,

et al. 2007

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The majority of US youth are of healthy weight, but the majority of US adults are overweight or obese. Therefore, a major health challenge for most American children and adolescents is obesity prevention-today, and as they age into adulthood. In this report, we review the most recent evidence regarding many behavioral and practice interventions related to childhood obesity, and we present recommendations to health care providers. Because of the importance, we also suggest approaches that clinicians can use to encourage obesity prevention among children, including specific counseling strategies and practice-based, systems-level interventions. In addition, we suggest how clinicians may interact with and promote local and state policy initiatives designed to prevent obesity in their communities.www.pediatrics.org/cgi

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“…The impact of obesity on reproductive health is particularly important because it can have long lasting consequences on future generations. This concept that maternal health and nutrition during pregnancy can have long-term effects on offspring is commonly known as the Barker Hypothesis, or the developmental origins of adult diseases [11].…”

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confidence: 99%

The impact of obesity on egg quality

Purcell

Moley

2011

J Assist Reprod Genet

136

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Obesity in women is a concern in many countries. This causes numerous health issues; however, this review focuses on the impact of obesity on women's reproduction, and in particular the oocyte. Data from infertility clinics and experimental animal models that address the effects of obesity are presented. Bidirectional communication and metabolic support from the surrounding cumulus cells are critical for oocyte development, and the impact of obesity on these cells is also addressed. Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations.

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Developmental origins of adult health and disease

Cited by 390 publications

References 0 publications

Trends in the association between blood pressure and obesity in a Taiwanese population between 1996 and 2006

Trends in the association between blood pressure and obesity in a Taiwanese population between 1996 and 2006

Recommendations for Prevention of Childhood Obesity

The impact of obesity on egg quality

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