Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable Diseases

Baird, Janis; Jacob, Chandni Maria; Barker, Mary; Fall, Caroline H.D.; Hanson, Mark A.; Harvey, Nicholas C.; Inskip, Hazel; Kumaran, Kalyanaraman; Cooper, Cyrus

doi:10.3390/healthcare5010014

Cited by 160 publications

(143 citation statements)

References 60 publications

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“…Much evidence supports a role for lutein and zeaxanthin in visual functions amongst older adults, but beneficial effects of these carotenoids on macular health may manifest in early life [2,26]. Assessments of lutein and zeaxanthin status at the end of life may result in a missed opportunity to identify the critical periods, sensitive periods, and cumulative effects of the relationship of lutein and zeaxanthin with macular health later in life.…”

Section: Discussionmentioning

confidence: 99%

Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study

et al. 2020

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Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother–child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions.

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Section: Discussionmentioning

confidence: 99%

Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study

et al. 2020

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“…Yet, we also know that the capacity for health-related change decreases as individuals age (Hanson & Gluckman, 2014) and offenders often have health conditions before they are incarcerated (Fazel & Baillargeon, 2011). Furthermore, life-course perspectives on health indicate intervention efforts are most effective when they occur earlier in development (Baird et al, 2017;Hanson & Gluckman, 2014). Crucially, then, improving health should occur as early in one's confinement period as possible.…”

Section: Mitigating Health-related Reentry Failuresmentioning

confidence: 99%

Consequences of mental and physical health for reentry and recidivism: Toward a health‐based model of desistance*

2019

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During the last few decades, criminologists have identified several adult roles and statuses, including employment, positive family relations, and economic stability, as critical for promoting successful reintegration and desistance. Very few researchers, however, have investigated the conditions that serve to bring about these transitions and successes crucial for behavior change. As a complement to a burgeoning amount of literature on the impact of incarceration on health, we emphasize the reverse: Health has important implications for reentry outcomes and reincarceration. Informed by multiple disciplines, we advance a health‐based model of desistance in which both mental and physical dimensions of health affect life chances in the employment and family realms and ultimately recidivism. Investigating this issue with longitudinal data from the Serious and Violent Offender Reentry Initiative (SVORI) and structural equation models, we find overall support for the health‐based model of desistance. Our results indicate several significant pathways through which both manifestations of health influence employment, family conflict, financial problems, and crime and reincarceration. The findings highlight the need for implementation of correctional and transitional policies to improve health among the incarcerated and avert health‐related reentry failures.

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“…The DOHaD hypothesis proposes that the pre-and postnatal periods are a time when adverse environments can initiate long-term consequences for health from chronic non-communicable disease (Baird et al, 2017). The fetus adjusts its developmental trajectory in response to environmental cues.…”

Section: Discussionmentioning

confidence: 99%

Using teeth as tools: Investigating the mother–infant dyad and developmental origins of health and disease hypothesis using vitamin D deficiency

Brickley

Kahlon

D’Ortenzio

2019

American J Phys Anthropol

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Objectives: With a growing interest in the mother-infant dyad and the Developmental Origins of Health and Disease hypothesis among biological and medical anthropologists, this study set out to provide all the information required to evaluate if mineralization defects in dentine might be caused by vitamin D deficiency in the critical first 1000 days of life.Materials and Methods: Information was compiled on dentine formation in utero to approximately 18 years, and a method for determining the location of the neonatal line in dentine was devised, allowing the assessment of the prenatal and early life period. Reevaluation of previously analyzed teeth (n = 61) was undertaken with detailed examination of n = 5/22 first permanent molars forming in the prenatal and critical early life periods.Results: First permanent molars and all deciduous teeth give information on intrauterine development and on the first 1000 days postnatally providing a direct window on maternal and fetal health. Three archaeological individuals had interglobular dentine that formed prenatally suggesting that their mothers experienced vitamin D deficiency at the time dentine was forming and all other individuals had a deficiency during the first 1000 days of life. Conditions that could cause systemic mineralization defects were determined, and in each, case they were found to be consistent with vitamin D deficiency.Discussion: The neonatal line serves as a clear baseline for determining prenatal and postnatal events, particularly those related to vitamin D, calcium, and phosphate metabolism, and can be used to investigate the maternal-infant dyad for both past and present communities. K E Y W O R D S interglobular dentine, maternal health, neonatal line, prenatal vitamin D deficiency 1 | INTRODUCTION Teeth provide a permanent biological marker of metabolic stressors that disrupt mineralization in utero and early childhood. This is signifi-cant for both medical and biological anthropologists interested in the mother-infant dyad and the Developmental Origins of Health and Disease hypothesis (DOHaD), offering insights into maternal health and a means by which theoretical approaches linked to early life conditions that affect development can be tested and developed. DOHaD is a paradigm that explores how early life environments, particularly Megan B. Brickley and Lori D'Ortenzio contributed equally to this study.

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Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable Diseases

Cited by 160 publications

References 60 publications

Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study

Maternal Lutein and Zeaxanthin Concentrations in Relation to Offspring Visual Acuity at 3 Years of Age: The GUSTO Study

Consequences of mental and physical health for reentry and recidivism: Toward a health‐based model of desistance*

Using teeth as tools: Investigating the mother–infant dyad and developmental origins of health and disease hypothesis using vitamin D deficiency

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