Developmental origins of health and disease – Global public health implications

Hanson, Mark A.; Gluckman, Peter D.

doi:10.1016/j.bpobgyn.2014.06.007

Cited by 156 publications

(115 citation statements)

References 28 publications

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“…This concept suggests new links of causality and infers the early establishment of metabolic adjustments that determine morbidity throughout life, especially those causatively associated with NCDs, 6,7) leading to a new branch of scientific knowledge known as the 'DOHaD' theory. 4,10,11) …”

Section: Developmental Origins Of Health and Disease (Dohad) Theorymentioning

confidence: 99%

Nutritional conditions in early life and risk of non-communicable diseases (NCDs) from the perspective of preemptive medicine in perinatal care

Itoh

Kanayama

2015

Hypertens Res Pregnancy

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Section: Developmental Origins Of Health and Disease (Dohad) Theorymentioning

confidence: 99%

Nutritional conditions in early life and risk of non-communicable diseases (NCDs) from the perspective of preemptive medicine in perinatal care

Itoh

Kanayama

2015

Hypertens Res Pregnancy

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“…Currently, in developed societies there is a domination of stagnation over motion [13]. Therefore, the search for methods that drive positive changes in human behavior, manifested in an active leisure time in the aquatic environment, is of prime importance.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity in the Water Accompanied by Music

Kwaśna

Szczepan

Spirydowicz

et al. 2016

Polish Hyperbaric Research

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Introduction: Music motivates, relaxes and stimulates action and is one factor which enhances the pleasure that people feel from a given movement. Thus, from a psychophysical point of view, listening to music is an important aspect in sport and recreation. With this in mind, the aim of the study was to determine any changes in the participants' psychophysical sphere which resulted from listening to music while swimming. The psychophysical sphere was expressed in relation to the Borg RPE scale (Rating of Perceived Exertion) as well as the Rejeski and Gauvin Exercise-Induced Feeling Inventory (EFI) scale of emotional states. Material and methods: The participants in the study were not professional swimmers (n = 10). The experiment consisted of two trials in which participants performed the Swimming Cooper test. During the first trial there was no music transmitted while in the second trial specifically selected music was played as the participants swam. Results: An ANOVA variance analysis (α = 0.05) showed statistically significant differences in the RPE scale (p = 0.04) and across all sensations on the EFI scale (p = 0.001, p = 0.001, p = 0.001, p = 0.001). Conclusions: Listening to music while swimming has a significant impact on the human psychophysical sphere and is expressed by a perceived exertion scale and the scale of emotional states. Respondents paid less attention to the discomfort of physical exertion associated with exercise while listening to music. The rating of their emotional states, including positive engagement, revitalization and tranquility considerably increased though the physical exhaustion measures were significantly lower.

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“…The time interval of the substantial increase observed in incidence of many NCDs 21 was much too short to be attributable to genetic change. The developmental origins of health and disease (DOHaD) concept has started to gain broad acceptance, proposing that a body's development is plastic, and that it allows the organism to respond to the surrounding environment, especially during early development (Gluckman et al, 2008;Gluckman et al, 2009;Barouki et al, 2012;Hanson and Gluckman, 2015). This concept is based on an increasing number of epidemiological studies that suggest that environmental factors, such as nutrients, environmental chemicals, drugs, infections and other stressors in early developmental period can lead to adverse chronic consequences later in the course of life (Nickerson, 2006b;Nagayama et al, 2007a;Barouki et al, 2012;Ochiai et al, 2014;Vaiserman, 2015).…”

Section: Early-life Exposure To Pops May Influence People's Health Ovmentioning

confidence: 99%

“…The four main types of NCDs are cardiovascular diseases (such as heart attacks and stroke), cancers, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes (Figure 1.1). The more frequent occurrence of other categories of NCDs (including mental illness, cognitive decline, and allergic diseases) has also contributed to the gradual rise of public concern (Gluckman and Hanson, 2006;Hanson and Gluckman, 2015). DALYs, 1990DALYs, -2010 (DALYs refers to the sum of years lost due to premature death and years lived with disability, and are also defined as years of healthy life lost) (source: (IHME, 2013)) The mechanisms implicated in the developmental programming of NCDs are poorly understood (Hanson and Gluckman, 2011).…”

Section: Early-life Exposure To Pops May Influence People's Health Ovmentioning

confidence: 99%

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Assessing body burden of persistent organic pollutants (POPs) in infants/toddlers through analysis of faeces

Chen¹

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The fact that non-communicable diseases (NCDs) have become the leading causes of death and disability over the past two decades globally warrants dedicated research and the implementation of prevention strategies. Global restrictions/bans have been placed on persistent organic pollutants (POPs) due to the links between early-life exposure to them and NCD risks that have been observed in epidemiological studies. Certain POP groups (such as polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and polybrominated diphenylethers (PBDEs)) are present/persistent in human breast milk at considerable levels several decades/years despite restrictions/bans. Increased understanding of exposureresponse relationship is now needed to confirm the significant pollutants exposures and their exposure windows. Individual data from early childhood biomonitoring POPs is, therefore, vital.Direct measurements of body burdens in early childhood have been a challenge, due to the reduced availability of invasive-biomonitoring (such as blood sampling) under ethical and practical considerations. Early-childhood biomonitoring studies typically rely on measurements of breast milk concentrations and/or modelling the body burden of POPs in infants/toddlers using intake estimates and growth data. Previously, concentrations of selected POPs in faeces of adults were reported to be largely independent of the dietary intake of chemicals, but dependent on the body burden. Thus, this thesis aimed to investigate the viability of using faeces as a non-invasive matrix for estimating the body burden of POPs in infant/toddlers. Faeces, as a biomonitoring matrix, was not well-documented for both the convenience and the practical scope previously. An effective analytical method, including sampling faeces and POPs extraction/cleanup and quantification, was developed and had been modified throughout the study with recent advances in sample-preparation techniques. Based on the effective analytical method, the relationship between the POP concentrations in faeces and the body burden (assessed via breast milk and blood samples) in infants/toddlers was then investigated.The measured concentrations of POPs in the faeces of a group of 7 infants/toddlers were compared to existing pooled blood serum data from children (0-4 years) in Australia (Chapter 2). The similarity of POP profiles observed between the existing blood data and the collected faeces samples hold promise for the viability of faecal analysis as an early-exposure biomonitoring tool. Subsequently, matched breast milk and faecal samples from 10 mother-child pairs were obtained and analyzed with the distribution of individual exposure levels of infants/toddlers and the correlation between exposure and faecal concentrations being investigated for the first time (Chapter 3). 3The monthly variation of POP concentrations in faeces over the first year of life of one infant was investigated and compared to modelled blood concentrations (Chapter 4). The results showed the POP concentrations ...

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Developmental origins of health and disease – Global public health implications

Cited by 156 publications

References 28 publications

Nutritional conditions in early life and risk of non-communicable diseases (NCDs) from the perspective of preemptive medicine in perinatal care

Nutritional conditions in early life and risk of non-communicable diseases (NCDs) from the perspective of preemptive medicine in perinatal care

Physical Activity in the Water Accompanied by Music

Assessing body burden of persistent organic pollutants (POPs) in infants/toddlers through analysis of faeces

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