Developmental Origins of Renal Disease

Bagby, Susan P.

doi:10.2215/cjn.06101108

Cited by 34 publications

(34 citation statements)

References 26 publications

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“…168 Neonates in intensive care units are often small and preterm and receive nephrotoxic medications (nonsteroidal anti-inflammatory drugs, aminoglycosides) that may affect nephrogenesis. It may be time to develop safer treatment protocols especially for infections.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Importance of Nephron Mass

Luyckx

Brenner²

2010

Journal of the American Society of Nephrology

277

243

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Section: Discussionmentioning

confidence: 99%

The Clinical Importance of Nephron Mass

Luyckx

Brenner²

2010

Journal of the American Society of Nephrology

277

243

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“…Interestingly, male SBP approached expected values at 3 years of age, when weight-for-height z-scores did not differ from zero and SBPz and SS had fallen, suggesting that body composition and growth contribute to BP regulation in preterm infants. Since preterm birth may occur before completing nephrogenesis [36], reno-vascular development may be altered and the risk of hypertension increased [37,38]. This, however, has not been examined.…”

Section: Discussionmentioning

confidence: 99%

Elevated systolic blood pressure in preterm very-low-birth-weight infants ≤3 years of life

et al. 2011

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Preterm, very-low-birth-weight neonates (≤1500 gm, VLBW) exhibit elevated systolic blood pressures (SBP) in adolescence and adulthood; however, the age of onset and causes are unknown. We assessed SBP in a cross-sectional study of VLBW infants at 1, 2 and 3 years of age (n = 40 per cohort). SBP was manually measured using Doppler amplification (observed), and calm values were compared to reference ranges used for clinical purposes (expected). SBP was converted to age-, gender- and height-specific z-scores (SBPz). Perinatal variables and growth parameters measured between 6 and 36 months were assessed as predictors of an elevated SBP. Observed SBP and SBPz exceeded the expected value at each age (P < 0.01); for example 1 year SBP was 94 ± 10 (standard deviation) vs. 85 ± 3 mmHg, respectively. Although the expected SBP rose from 85 ± 3 to 90 ± 3 mmHg with advancing age (P < 0.05), VLBW SBP was unchanged (P > 0.1), averaging 93 mmHg across ages. Height and weight z-scores were below expected (P < 0.01), while weight-for-height z-scores exceeded zero at 6, 12 and 24 months (P < 0.05). Male subscapular skinfold thickness:abdominal circumference ratio decreased with advancing age, paralleling the decreases in SBPz. The VLBW neonates demonstrated an elevated SBP as early as 1 year of age. Although predictive perinatal variables were not identified, gender-specific relationships between infant growth and SBP were observed.

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“…Prematurity, maternal stress, and nutrient deficiencies are among factors that increase risk of fetally programmed disease. 1,2 Brenner et al postulated that such influences might reduce nephron count and numerous studies have since shown that low nephron number is associated with increased risk of essential hypertension. 3,4 Moreover, a marked 10-fold range in nephron number has been observed between various patient populations undergoing autopsy for unexpected death.…”

mentioning

confidence: 99%

Developmental Programming of Branching Morphogenesis in the Kidney

Sampogna

Schneider

Al‐Awqati

2015

Journal of the American Society of Nephrology

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The kidney developmental program encodes the intricate branching and organization of approximately 1 million functional units (nephrons). Branching regulation is poorly understood, as is the source of a 10-fold variation in nephron number. Notably, low nephron count increases the risk for developing hypertension and renal failure. To better understand the source of this variation, we analyzed the complete gestational trajectory of mouse kidney development. We constructed a computerized architectural map of the branching process throughout fetal life and found that organogenesis is composed of two distinct developmental phases, each with stage-specific rate and morphologic parameters. The early phase is characterized by a rapid acceleration in branching rate and by branching divisions that repeat with relatively reproducible morphology. The latter phase, however, is notable for a significantly decreased yet constant branching rate and the presence of nonstereotyped branching events that generate progressive variability in tree morphology until birth. Our map identifies and quantitates the contribution of four developmental mechanisms that guide organogenesis: growth, patterning, branching rate, and nephron induction. When applied to organs that developed under conditions of malnutrition or in the setting of growth factor mutation, our normative map provided an essential link between kidney architecture and the fundamental morphogenetic mechanisms that guide development. This morphogenetic map is expected to find widespread applications and help identify modifiable targets to prevent developmental programming of common diseases.

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Developmental Origins of Renal Disease

Cited by 34 publications

References 26 publications

The Clinical Importance of Nephron Mass

The Clinical Importance of Nephron Mass

Elevated systolic blood pressure in preterm very-low-birth-weight infants ≤3 years of life

Developmental Programming of Branching Morphogenesis in the Kidney

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