Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning

Fc, Widmer; Keller, Georg B.

doi:10.1101/2021.06.20.449148

Cited by 10 publications

(8 citation statements)

References 47 publications

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“…However, we do not expect the learning of PE neurons to be compromised when all inhibitory synapses are plastic. Recently, it has been shown that NMDA receptor–dependent plasticity in early development is crucial for the responses to unpredictable and predictable stimuli in V1 ( 58 ). This suggests that excitatory plasticity plays a pivotal role in the formation of PE neurons.…”

Section: Discussionmentioning

confidence: 99%

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications

Hertäg

Clopath

2022

Proc. Natl. Acad. Sci. U.S.A.

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Significance An influential idea in neuroscience is that neural circuits do not only passively process sensory information but rather actively compare them with predictions thereof. A core element of this comparison is prediction-error neurons, the activity of which only changes upon mismatches between actual and predicted sensory stimuli. While it has been shown that these prediction-error neurons come in different variants, it is largely unresolved how they are simultaneously formed and shaped by highly interconnected neural networks. By using a computational model, we study the circuit-level mechanisms that give rise to different variants of prediction-error neurons. Our results shed light on the formation, refinement, and robustness of prediction-error circuits, an important step toward a better understanding of predictive processing.

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Section: Discussionmentioning

confidence: 99%

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications

Hertäg

Clopath

2022

Proc. Natl. Acad. Sci. U.S.A.

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“…It is based on the finding that NMDA receptor antagonists induce schizophrenia-like symptoms (Moghaddam and Javitt, 2012), and that disturbances of NMDA and AMPA receptor related gene expression are associated with schizophrenia (Harrison and Weinberger, 2005; Singh et al, 2020). In V1, it has been shown that NMDA receptors are necessary during visual development to establish normal prediction error signaling (Widmer and Keller, 2021). Thus, it is conceivable that a disruption of glutamatergic signaling in cortex that alters the way internal representations are activated by prediction errors is central to the etiology of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers

Heindorf

Keller

2022

Preprint

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Psychosis is characterized by a diminished ability of the brain to distinguish externally driven activity patterns from self-generated activity patterns. Antipsychotic drugs are a class of small molecules with relatively broad binding affinity for a variety of neuromodulator receptors that, in humans, can prevent or ameliorate psychosis. How these drugs influence the function of cortical circuits and in particular their ability to identify self-generated activity patterns is still largely unclear. Here we used widefield calcium imaging to determine the cell type specific functional effects of antipsychotic drugs in mouse dorsal cortex during visuomotor integration. By comparing cell type specific activation patterns between locomotion onsets that were experimentally coupled to self-generated visual feedback and locomotion onsets that were not coupled, we show that deep cortical layers were differentially activated in these two conditions. We then show that the antipsychotic drug clozapine disrupted visuomotor integration at locomotion onsets also primarily in deep cortical layers. Given that one of the key components of visuomotor integration in cortex are long-range cortico-cortical connections, we tested whether the effect of clozapine was detectable in the correlation structure of activity patterns across dorsal cortex. We found that clozapine, as well as two other antipsychotic drugs, aripiprazole and haloperidol, resulted in a strong reduction in correlations of layer 5 activity between cortical areas and impaired the spread of visuomotor prediction errors generated in visual cortex. Our results are consistent with the interpretation that a major functional effect of antipsychotic drugs is an alteration of the activation of internal representations as a consequence of reduced long-range layer 5 mediated communication.

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“…All details of data acquisition were described previously (Attinger et al, 2017; Widmer and Keller, 2021). Data are publicly available on https://data.fmi.ch/PublicationSupplementRepo/.…”

Section: Methodsmentioning

confidence: 99%

“…All details of data acquisition were described previously (Attinger et al, 2017;Widmer and Keller, 2021).…”

Section: Methodsmentioning

confidence: 99%

“…To directly assess this, we analyzed three previously acquired two-photon calcium imaging datasets, recorded from layer 2/3 of V1, totaling 6901 neurons in 45 mice (see Methods). Two of these have been previously published and are publicly available (Attinger et al, 2017; Widmer and Keller, 2021), while one is not yet published. Mice were first exposed to the closed loop condition where visual flow was coupled to locomotion speed, and sudden 1 s halts in visual flow during locomotion were used to evoke mismatch responses.…”

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confidence: 99%

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Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

Vasilevskaya

Widmer

Keller

et al. 2022

Preprint

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The aim of this work is to provide a comment on a recent paper by Muzzu and Saleem (2021). In brief, our concern is that the authors claim that visuomotor mismatch responses in mouse visual cortex can be explained by a locomotion-induced gain of visual halt responses, without directly comparing these responses to mismatch responses. Without a direct comparison, the claim that one response can explain the other appears difficult to uphold, more so because previous work finds that a uniform locomotion-induced gain cannot explain mismatch responses. To support these arguments, we analyzed a series of layer 2/3 calcium imaging datasets and show that coupling between visual flow and locomotion greatly enhances mismatch responses in an experience dependent manner compared to halts in non-coupled visual flow. This is consistent with mismatch responses representing visuomotor prediction errors. Thus, we conclude that feature selectivity cannot explain mismatch responses in mouse visual cortex.

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Developmental plasticity in visual cortex is necessary for normal visuomotor integration and visuomotor skill learning

Cited by 10 publications

References 47 publications

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications

Prediction-error neurons in circuits with multiple neuron types: Formation, refinement, and functional implications

Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers

Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

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