Developmental Programming of Allergic Diseases

Pincus, Maike; Arck, Petra C.

doi:10.1159/000336499

Cited by 10 publications

(5 citation statements)

References 108 publications

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“…This is the time required for the buildup of a Th2 response and neuronal plasticity resulting in increased neurogenic inflammation. Moreover, stress exposure in utero or during early development is associated with high IgE levels, Th2 cytokines, and a higher incidence of atopic dermatitis symptoms. Adults with atopic dermatitis show an altered responsiveness of the HPA and SA to acute stress, corresponding to that of healthy individuals under chronic stress: hyporeactivity of the HPA and hyperreactivity of the SA.…”

Section: Specific Examples Of Neuroendocrine‐immune Interactions: Fromentioning

confidence: 99%

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Peters

2016

J Deutsche Derma Gesell

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SummaryA pathogenetically relevant link between stress, in terms of psychosocial stress, and disease was first described in the 1970s, when it was proven that viral diseases of mucous membranes (such as rhinovirus and Coxsackie virus infections) develop faster and more severe after stress exposure. Since then, there has been an annual increase in the number of publications which investigate this relationship and break it down to the molecular level. Nevertheless, the evidences for the impact of psychosocial stress on chronic inflammatory skin diseases and skin tumors are hardly known. In the present review, we outline current insights into epidemiology, psychoneuroimmunology, and molecular psychosomatics which demonstrate the manifold disease-relevant interactions between the endocrine, nervous, and immune systems. The focus is on stress-induced shifts in immune balance in exemplary disorders such as atopic dermatitis, psoriasis, and malignant melanoma. The objective of this article is to convey basic psychosomatic knowledge with respect to etiology, symptomatology, and therapeutic options for chronic skin diseases. Particular attention is directed towards the underlying molecular relationships, both from a somatic to mental as well as a mental to somatic perspective.

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Section: Specific Examples Of Neuroendocrine‐immune Interactions: Fromentioning

confidence: 99%

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Peters

2016

J Deutsche Derma Gesell

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“…Following birth and during the first postnatal year, the infant's immune system must rapidly develop in order to negotiate the infectious milieu of the extrauterine environment as well as to establish tolerance to abundant nonpathogenic antigens. The development of immune phenotypes during this time may define the risk of infective illnesses or program the subsequent risk of immune‐related disease 1 , 2 . Several studies have described the proportions of basic lymphocyte subsets at birth, 3 , 4 over the first year of life, 5 , 6 and during childhood and adolescence, 7 but there are limited data regarding the longitudinal natural development of these subsets or potential gender differences during the first postnatal year.…”

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confidence: 99%

“…(a) MNCs were stained with fluorochrome-labeled monoclonal antibodies to CD4, CD31 and CD45RA. Cells were gated to the CD4 + population, and CD45RA + naive cells were divided according to quadrant (1) (CD31 + /CD45RA + ) and quadrant(2) (CD31 − /CD45RA + ), with CD45RA − cells in quadrant (3) (CD31 − /CD45RA − ). Representativeflow plots at birth and 6 months are shown.…”

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confidence: 99%

The ontogeny of naïve and regulatory CD4⁺ T‐cell subsets during the first postnatal year: a cohort study

et al. 2015

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As there is limited knowledge regarding the longitudinal development and early ontogeny of naïve and regulatory CD4+ T-cell subsets during the first postnatal year, we sought to evaluate the changes in proportion of naïve (thymic and central) and regulatory (resting and activated) CD4+ T-cell populations during the first postnatal year. Blood samples were collected and analyzed at birth, 6 and 12 months of age from a population-derived sample of 130 infants. The proportion of naïve and regulatory CD4+ T-cell populations was determined by flow cytometry, and the thymic and central naïve populations were sorted and their phenotype confirmed by relative expression of T cell-receptor excision circle DNA (TREC). At birth, the majority (94%) of CD4+ T cells were naïve (CD45RA+), and of these, ~80% had a thymic naïve phenotype (CD31+ and high TREC), with the remainder already central naïve cells (CD31− and low TREC). During the first year of life, the naïve CD4+ T cells retained an overall thymic phenotype but decreased steadily. From birth to 6 months of age, the proportion of both resting naïve T regulatory cells (rTreg; CD4+CD45RA+FoxP3+) and activated Treg (aTreg, CD4+CD45RA−FoxP3high) increased markedly. The ratio of thymic to central naïve CD4+ T cells was lower in males throughout the first postnatal year indicating early sexual dimorphism in immune development. This longitudinal study defines proportions of CD4+ T-cell populations during the first year of postnatal life that provide a better understanding of normal immune development.

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“…Dies ist die Zeitspanne, die für den Aufbau einer TH2‐Antwort und zu verstärkter neurogener Entzündung führender neuronaler Plastizität gebraucht wird. Stressexposition in utero oder in der frühen Entwicklung ist assoziiert mit hohen IgE‐Spiegeln, TH2‐Zytokinen und einer höheren Inzidenz von Neurodermitis‐Symptomen . Akuter Stress bei erwachsenen Neurodermitikern trifft auf eine veränderte Reaktivität der HHNA und SA, entsprechend der Reaktion bei Gesunden unter chronischem Stress, das heisst die HHNA ist hyporeaktiv, die SA hyperreaktiv .…”

Section: Konkrete Beispiele Für Neuroendokrin‐immune Interaktion Vonunclassified

Gestresste Haut? – Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen

Peters

2016

J Deutsche Derma Gesell

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A pathogenetically relevant link between stress, in terms of psychosocial stress, and disease was first described in the 1970s, when it was proven that viral diseases of mucous membranes (such as rhinovirus and Coxsackie virus infections) develop faster and more severe after stress exposure. Since then, there has been an annual increase in the number of publications which investigate this relationship and break it down to the molecular level. Nevertheless, the evidences for the impact of psychosocial stress on chronic inflammatory skin diseases and skin tumors are hardly known. In the present review, we outline current insights into epidemiology, psychoneuroimmunology, and molecular psychosomatics which demonstrate the manifold disease-relevant interactions between the endocrine, nervous, and immune systems. The focus is on stress-induced shifts in immune balance in exemplary disorders such as atopic dermatitis, psoriasis, and malignant melanoma. The objective of this article is to convey basic psychosomatic knowledge with respect to etiology, symptomatology, and therapeutic options for chronic skin diseases. Particular attention is directed towards the underlying molecular relationships, both from a somatic to mental as well as a mental to somatic perspective.

show abstract

Developmental Programming of Allergic Diseases

Cited by 10 publications

References 108 publications

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

The ontogeny of naïve and regulatory CD4⁺ T‐cell subsets during the first postnatal year: a cohort study

Gestresste Haut? – Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen

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Developmental Programming of Allergic Diseases

Cited by 10 publications

References 108 publications

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

Stressed skin? – a molecular psychosomatic update on stress‐causes and effects in dermatologic diseases

The ontogeny of naïve and regulatory CD4+ T‐cell subsets during the first postnatal year: a cohort study

Gestresste Haut? – Aktueller Stand molekularer psychosomatischer Zusammenhänge und ihr Beitrag zu Ursachen und Folgen dermatologischer Erkrankungen

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The ontogeny of naïve and regulatory CD4⁺ T‐cell subsets during the first postnatal year: a cohort study