Developmental toxicity of domoic acid in zebrafish (Danio rerio)

Tiedeken, Jessica A.; Ramsdell, John S.; Ramsdell, Ann F.

doi:10.1016/j.ntt.2005.06.013

Cited by 69 publications

(39 citation statements)

References 35 publications

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“…developmental toxicity). This model system has been effectively employed to identify developmental toxicity associated with a number of wellrecognized toxins from marine and freshwater HABs Edmunds et al, 1999;Kimm-Brinson and Ramsdell, 2001;Liu et al, 2002;Colman and Ramsdell, 2003;Colman et al, 2004Colman et al, , 2005Lefebvre et al, 2004;Tiedeken et al, 2005). Equally, this system is being increasingly utilized to identify and characterize novel, or otherwise unrecognized, developmental toxins from algal sources (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…For example, recent studies of DA by Tiedeken et al (2005) utilized microinjection of zebrafish eggs to demonstrate morphological and behavioral dysfunction in embryos treated with the toxin. Specifically, dose-dependent effects were observed on hatching rate, and neurobehavioral parameters, including convulsions, stereotypically incessant movement of pectoral fins and impairment of touch-swim response, as well various morphological deformities (e.g.…”

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

“…Specifically, dose-dependent effects were observed on hatching rate, and neurobehavioral parameters, including convulsions, stereotypically incessant movement of pectoral fins and impairment of touch-swim response, as well various morphological deformities (e.g. pericardial swelling, curvature of the spine) that consequently decreased survival rate (Tiedeken et al, 2005). Given the recognized neuroexcitatory effects of DA via glutamate receptors, the observed behavioral dysfunction is perhaps not surprising, however, specific mechanisms for these and other effects, particularly including morphological abnormalities, have not been clarified.…”

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

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The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

Berry

Gantar

Gibbs

et al. 2007

Comparative Biochemistry and Physiology Part C: Toxicology &

109

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The zebrafish (Danio rerio) embryo has emerged as an important model of vertebrate development. As such, this model system is finding utility in the investigation of toxic agents that inhibit, or otherwise interfere with, developmental processes (i.e. developmental toxins), including compounds that have potential relevance to both human and environmental health, as well as biomedicine. Recently, this system has been applied increasingly to the study of microbial toxins, and more specifically, as an aquatic animal model, has been employed to investigate toxins from marine and freshwater microalgae, including those classified among the so-called "harmful algal blooms" (HABs). We have developed this system for identification and characterization of toxins from cyanobacteria (i.e. "blue-green algae") isolated from the Florida Everglades and other freshwater sources in South and Central Florida. Here we review the use of this system as it has been applied generally to the investigation of toxins from marine and freshwater microalgae, and illustrate this utility as we have applied it to the detection, bioassay-guided fractionation and subsequent characterization of developmental toxins from freshwater cyanobacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

Section: Freshwater Fish As Models For Developmental Toxins From Marimentioning

confidence: 99%

See 1 more Smart Citation

The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

Berry

Gantar

Gibbs

et al. 2007

Comparative Biochemistry and Physiology Part C: Toxicology &

109

View full text Add to dashboard Cite

show abstract

“…Furthermore, DOM accumulates without apparent lethality in a variety of benthic organisms (Lefebvre et al 2002a(Lefebvre et al , b, 2007, although more subtle neurological effects have been observed following exposure during development (Tiedeken et al 2005). DOM also does not appear to subserve an allelopathic role to discourage competition between algal species (Lundholm et al 2005).…”

Section: Natural Sources and Synthetic Analogs Of Kainoidsmentioning

confidence: 99%

Developmental Biology of Neoplastic Growth

Macieira‐Coelho¹

2005

Progress in Molecular and Subcellular Biology

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“…A majority of DA uptake was excreted via kidney and bile in fish, with the remaining absorbed DA mainly detected in liver, heart, spleen and muscle [4]. Limited data was available on in vivo metabolism in fish, although previous studies suggested that the biotransformation and detoxification pathways of Phase I and/or Phase II xenobiotic metabolism enzymes (XMEs) were involved in DA metabolism [5]. Further investigations using intraperitoneal (I.P.)…”

mentioning

confidence: 99%

Effects of dietary tert-butylhydroquinone on domoic acid metabolism and transcription of detoxification-related liver genes in red sea bream Pagrus major

Liang

Shen

et al. 2013

Chin. Sci. Bull.

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Domoic acid (DA) is a neuroexcitatory amino acid that is produced by Pseudo-nitzschia during harmful algal blooms (HAB). Accumulation of DA can be transferred through food chain and cause neuronal damage in marine animal and in human. Like other algal toxins, DA was suggested to increase the oxidative stress and increase the detoxification-related gene expression in fish. The widely used food antioxidant, tert-butylhydroquinone (tBHQ), was known to induce a wide range of antioxidative potentials such as elevation of the glutathione levels and glutathione S-transferases (GSTs), via the activation of antioxidant response elements (AREs). In this study, the influences of dietary tBHQ on domoic acid (DA) metabolism and detoxification-related gene transcription were investigated both in vivo and in vitro. Oral administration of tBHQ resulted in significant decreases of DA accumulation of liver tissues in which red sea bream were fed with a single dose of 10 mg DA and 100 mg tBHQ per kg body weight per fish. Real-time PCR further revealed that the mRNA levels of AHR/ARNT/CYP1A1/GSTA1/GSTR were up-regulated in the above liver tissues at 72 h post tBHQ treatment. In consistence, tBHQ exposure also resulted in increased mRNA transcription of GSTA1, GSTA2 and GSTR in cultured red sea bream hepatocytes. Collectively, our findings in this research suggested that the dietary intake of tBHQ accelerated DA metabolism in fish, through mechanisms involving altered transcription of detoxificationrelated liver genes. Domoic acid is an excitatory neurotoxin produced by marine diatoms of the genus Pseudo-nitzschia. It is responsible for a neurotoxic disease called amnesic shellfish poisoning (ASP) in human and marine mammals following consumption of DA (domoic acid)-contaminated fish. Symptoms of ASP include short-term memory loss, brain damage and death in severe cases. During harmful algal blooms, accumulation of high concentration of DA has been reported for a number of marine species such as types of cockles (Cerastoderma edule), crabs (Cancer magister), furrow shell (Scrobicularia plana), mussels (Mytilus edulis), razor clams (Siliqua patula) and scallops (Pecten maximus) [1][2][3]. Other fish species, such as anchovies and mackerel, have also been shown to accumulate DA, although at much lower levels compared with those found in shellfish [3]. A majority of DA uptake was excreted via kidney and bile in fish, with the remaining absorbed DA mainly detected in liver, heart, spleen and muscle [4]. Limited data was available on in vivo metabolism in fish, although previous studies suggested that the biotransformation and detoxification pathways of Phase I and/or Phase II xenobiotic metabolism enzymes (XMEs) were involved in DA metabolism [5]. Further investigations using intraperitoneal (I.P.) injection of DA in fish revealed that a receptor-mediated induction of

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Developmental toxicity of domoic acid in zebrafish (Danio rerio)

Cited by 69 publications

References 35 publications

The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

The zebrafish (Danio rerio) embryo as a model system for identification and characterization of developmental toxins from marine and freshwater microalgae

Developmental Biology of Neoplastic Growth

Effects of dietary tert-butylhydroquinone on domoic acid metabolism and transcription of detoxification-related liver genes in red sea bream Pagrus major

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