Developmental toxicity of -selenomethionine in Macaca fascicularis*1

Tarantal, Alice F.

doi:10.1016/0272-0590(91)90143-r

Cited by 34 publications

(2 citation statements)

References 44 publications

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“…1991, Tarantal et al 1991, and Chemoff and Kavlock 1982. Detailed summaries of the results of each study are listed in Appendix E. All studies considered reproductive effects following oral exposure to organic or inorganic selenium compounds.…”

Section: Seleniummentioning

confidence: 99%

Toxicological benchmarks for wildlife: 1996 Revision

Sample¹,

Opresko²,

Suter³

1996

128

146

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Section: Seleniummentioning

confidence: 99%

Toxicological benchmarks for wildlife: 1996 Revision

Sample¹,

Opresko²,

Suter³

1996

128

146

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“…It is this use that revealed the poisonous properties of selenium, which caused frequent poisoning and selenium-induced deaths in industrial workers (3,4). Reports that selenium is toxic to farm animals (5-7), that it has teratogenic effects in birds (8), non-human primates and man (9-11), and that its high doses might also be carcinogenic (11) further strengthened the notion that selenium is toxic to any living organism. This view held firm until the mid-1950s when it was first reported that trace amounts of selenium (and molybdate) are required for optimal enzymatic properties of intestinal Escherichia coli (12) and that selenium is essential for rodent survival (13).…”

mentioning

confidence: 99%

Synthesis and decoding of selenocysteine and human health

Schmidt¹,

Simonović²

2012

Croat Med J

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Selenocysteine, the 21st amino acid, has been found in 25 human selenoproteins and selenoenzymes important for fundamental cellular processes ranging from selenium homeostasis maintenance to the regulation of the overall metabolic rate. In all organisms that contain selenocysteine, both the synthesis of selenocysteine and its incorporation into a selenoprotein requires an elaborate synthetic and translational apparatus, which does not resemble the canonical enzymatic system employed for the 20 standard amino acids. In humans, three synthetic enzymes, a specialized elongation factor, an accessory protein factor, two catabolic enzymes, a tRNA, and a stem-loop structure in the selenoprotein mRNA are critical for ensuring that only selenocysteine is attached to selenocysteine tRNA and that only selenocysteine is inserted into the nascent polypeptide in response to a context-dependent UGA codon. The abnormal selenium homeostasis and mutations in selenoprotein genes have been causatively linked to a variety of human diseases, which, in turn, sparked a renewed interest in utilizing selenium as the dietary supplement to either prevent or remedy pathologic conditions. In contrast, the importance of the components of the selenocysteine-synthetic machinery for human health is less clear. Emerging evidence suggests that enzymes responsible for selenocysteine formation and decoding the selenocysteine UGA codon, which by extension are critical for synthesis of the entire selenoproteome, are essential for the development and health of the human organism.

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