“…The remaining studies (n = 11; 22%)[32, 36, 38, 48,53,54,57,59, 61,72, 78] were non-speci c about the weeks of gestation or trimester when SOC was measured. Thirteen of the 18 studies were prospective cohorts[31,34, 48,55,57, 60, 63, 64, 66, 69,72,75, 78] while the remaining ve[36, 38,53,59, 61] were crosssectional in study design. Of the studies specifying a trimester of pregnancy when SOC was measured, four studies[32,37,50,79] involved subjects in their second and third trimesters while two studies[65, 76] involved pregnant responders at the rst and third trimester.…”