Developmental Trajectory of Object Recognition Memory in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions

Zeamer, Alyson; Heuer, Eric; Bachevalier, Jocelyne

doi:10.1523/jneurosci.0022-10.2010

Cited by 74 publications

(128 citation statements)

References 50 publications

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“…Indeed, provided the pictures used are dissimilar, VPC leads to the same conclusion as DNMS: Recognition memory is spared by selective hippocampal lesions and color is not the determinant factor for such VPC sparing to occur as it is equally present with dissimilar BW pictures with gray shading replacing colors. This conclusion is strengthened by our recent results that animals with hippocampal lesions in the present study with spared recognition memory in VPC with dissimilar color and BW pictures also showed spared performance when subsequently tested on DNMS (Heuer and Bachevalier 2010).…”

Section: Vpc Vs Dnms: Narrowing the Gapsupporting

confidence: 84%

Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions

Zeamer

Meunier²,

Bachevalier³

2011

Learn. Mem.

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Recognition memory impairment after selective hippocampal lesions in monkeys is more profound when measured with visual paired-comparison (VPC) than with delayed nonmatching-to-sample (DNMS). To clarify this issue, we assessed the impact of stimuli similarity and encoding duration on the VPC performance in monkeys with hippocampal lesions and sham-operated controls. The novelty preference was compared for pictures of dissimilar vs. similar objects and for encoding duration of 30, 10, 5, and 1 sec. The novelty preference was spared after hippocampal lesions with dissimilar (colored or black and white [BW]) stimuli and an encoding time ≥10 sec, but declined with similar stimuli or a short encoding time of 1 or 5 sec. Therefore, the severe VPC impairment reported earlier after hippocampal damage cannot be attributed to the long encoding time used (30 sec) relative to DNMS (1-5 sec). However, it may result, at least in part, from the poorer distinctiveness of the stimuli typically used for VPC (BW slides of pictures of equal size and brightness of objects differing in shape) relative to the actual objects used for DNMS, differing in shape, color, size, brightness, and texture. This conclusion fits well with current models that view the hippocampus as a comparator capable of individualizing the representations of highly overlapping inputs.

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Section: Vpc Vs Dnms: Narrowing the Gapsupporting

confidence: 84%

Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions

Zeamer

Meunier²,

Bachevalier³

2011

Learn. Mem.

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“…In particular, we think that the novelty of the material to be remembered and the higher information load demand in our task, as compared with the odor span task, which proportionally loaded the object working memory system, allowed us to find an effect of HP lesion (Kumaran and Maguire 2007). Furthermore, it has been recently shown that neonatal hippocampus selective lesion in monkeys strongly impairs adulthood novel object recognition in a nonassociative task (incidental learning task based on spontaneous preference for novel objects) (Zeamer et al 2010), but did not affect it when animals are trained to respond to novelty upon instrumental contingency (Heuer and Bachevalier 2011). This suggests that the nonassociative nature of our task, which makes it quite close to incidental learning in humans and monkeys, might have favored the recruitment of the HP in the object task.…”

Section: The Dorsal Hippocampus Mediates Object Stm In High Memory Lomentioning

confidence: 86%

Role of the dorsal hippocampus in object memory load

Sannino¹,

Russo²,

Torromino³

et al. 2012

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The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed a novel behavioral procedure to study object memory load in mice by progressively increasing the stimulus set size in the spontaneous object recognition task. Using this procedure, we demonstrated that naive mice have a memory span, which is the number of elements they can remember for a short-time interval, of about six objects. Then, we showed that excitotoxic selective lesions of the dorsal hippocampus did not impair novel object discrimination in the condition of low memory load. In contrast, the same lesion impaired novel object discrimination in the high memory load condition, and reduced the object memory span to four objects. These results have important heuristic and clinical implications because they open new perspective toward the understanding of the role of the hippocampus in item memory and in memory span deficits occurring in human pathologies, such as Alzheimer's disease and schizophrenia.[Supplemental material is available for this article.]The dorsal hippocampus-HP (the CA fields, dentate gyrus, and subicular complex) is generally crucial for mammalian memory, but its exact role in memory formation is still hotly debated around a conspicuous number of rival theories. Although, in the early 1980s, Olton and colleagues (Wible et al. 1992;Wan et al. 1994) showed that HP lesions produced an impairment on both spatial and nonspatial memory independently on the retention time interval, converging evidence presented a dichotomous view between spatial and item memory (Brown and Aggleton 2001), and between short-term (STM) and long-term (LTM) memory (Shrager et al. 2008), regarding the role of the HP. Brown and Aggleton (2001) proposed that the HP is essential for associational, multi-item, re-collective aspects of recognition memory, but has little or no involvement for single item recognition, which would be mediated by the perirhinal cortex. Squire and colleagues (Broadbent et al. 2004), in contrast, suggested that the HP is selectively involved in LTM, and not in STM or working memory (WM), independently of the nature of the information.Studies in rodents unequivocally demonstrated that HP lesions impair memory consolidation of newly acquired spatial information, and quite consistently affect spatial STM, thus suggesting that the HP is involved in spatial memory

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“…Using these tasks, novelty preference has been demonstrated following short-term retention periods (Bachevalier and Nemanic, 2008;Pascalis and de Schonen, 1994;Jutras and Buffalo, 2010;Zeamer et al, 2010) in both human infants and monkeys. A number of studies have also documented novelty preference following long-term retention intervals (Gunderson and Swartz, 1985;Pascalis et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Recognition memory in tree shrew (Tupaia belangeri) after repeated familiarization sessions

Khani¹,

Rainer

2012

Behavioural Processes

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Recognition memories are formed during perceptual experience and allow subsequent recognition of previously encountered objects as well as their distinction from novel objects. As a consequence, novel objects are generally explored longer than familiar objects by many species. This novelty preference has been documented in rodents using the novel object recognition (NOR) test, as well is in primates including humans using preferential looking time paradigms. Here, we examine novelty preference using the NOR task in tree shrew, a small animal species that is considered to be an intermediary between rodents and primates. Our paradigm consisted of three phases: arena familiarization, object familiarization sessions with two identical objects in the arena and finally a test session following a 24-h retention period with a familiar and a novel object in the arena. We employed two different object familiarization durations: one and three sessions on consecutive days. After three object familiarization sessions, tree shrews exhibited robust preference for novel objects on the test day. This was accompanied by significant reduction in familiar object exploration time, occurring largely between the first and second day of object familiarization. By contrast, tree shrews did not show a significant preference for the novel object after a one-session object familiarization. Nonetheless, they spent significantly less time exploring the familiar object on the test day compared to the object familiarization day, indicating that they did maintain a memory trace for the familiar object. Our study revealed different time courses for familiar object habituation and emergence of novelty preference, suggesting that novelty preference is dependent on well-consolidated memory of the competing familiar object. Taken together, our results demonstrate robust novelty preference of tree shrews, in general similarity to previous findings in rodents and primates.

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Developmental Trajectory of Object Recognition Memory in Infant Rhesus Macaques with and without Neonatal Hippocampal Lesions

Cited by 74 publications

References 50 publications

Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions

Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions

Role of the dorsal hippocampus in object memory load

Recognition memory in tree shrew (Tupaia belangeri) after repeated familiarization sessions

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