Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development

Pértile, Renata Aparecida Nedel; Kiltschewskij, Dylan J; Geaghan, Michael P; Barnett, Michelle; Cui, Xiaoying; Cairns, Murray J.; Eyles, Darryl W.

doi:10.1016/j.brainres.2022.147953

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…in SH-SY5Y/VDR+ cells (Aparecida Nedel Pertile et al, 2022;Cui, Pertile, et al, 2015;Pertile et al, 2016). However, we note that although FFN200 is readily taken up into these cells, we were not able to pharmacologically release them from SH-SY5Y/VDR+ TH+ cells not exposed to 1,25OHD using amphetamine.…”

Section: Vitamin D In Cre a S E S Dopamine Synthe S Is And Rele A S Ementioning

confidence: 66%

“…Many of these microRNAs have a role in suppressing neurite elongation. In particular, we show that when one such microRNA -181c-5p is over-expressed in TH+ SH-SY5Y/ VDR+ cells this leads to truncated neurite extension (Aparecida Nedel Pertile et al, 2022). Whether the addition of 1,25OHD to cultured neurons reverses this process to block the production of such an inhibitory microRNA is unknown.…”

Section: Vitamin D Enhan Ce S Neurite Outg Row Thmentioning

confidence: 91%

“…To the best of our knowledge, our group is the 1st to report the use of this agent in differentiated SH‐SY5Y neuroblastoma cells. We chose these cells as we have amassed a substantial amount of data regarding the DA‐promoting differentiation effects of 1,25OHD in SH‐SY5Y/VDR+ cells (Aparecida Nedel Pertile et al, 2022; Cui, Pertile, et al, 2015; Pertile et al, 2016). However, we note that although FFN200 is readily taken up into these cells, we were not able to pharmacologically release them from SH‐SY5Y/VDR+ TH+ cells not exposed to 1,25OHD using amphetamine.…”

Section: Vitamin D Increases Dopamine Synthesis and Releasementioning

confidence: 99%

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Vitamin D: A potent regulator of dopaminergic neuron differentiation and function

Pértile

Brigden

Raman

et al. 2023

Journal of Neurochemistry

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Vitamin D has been identified as a key factor in dopaminergic neurogenesis and differentiation. Consequently, developmental vitamin D (DVD) deficiency has been linked to disorders of abnormal dopamine signalling with a neurodevelopmental basis such as schizophrenia. Here we provide further evidence of vitamin D's role as a mediator of dopaminergic development by showing that it increases neurite outgrowth, neurite branching, presynaptic protein re‐distribution, dopamine production and functional release in various in vitro models of developing dopaminergic cells including SH‐SY5Y cells, primary mesencephalic cultures and mesencephalic/striatal explant co‐cultures. This study continues to establish vitamin D as an important differentiation agent for developing dopamine neurons, and now for the first time shows chronic exposure to the active vitamin D hormone increases the capacity of developing neurons to release dopamine. This study also has implications for understanding mechanisms behind the link between DVD deficiency and schizophrenia.image

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Section: Vitamin D In Cre a S E S Dopamine Synthe S Is And Rele A S Ementioning

confidence: 66%

Section: Vitamin D Enhan Ce S Neurite Outg Row Thmentioning

confidence: 91%

Section: Vitamin D Increases Dopamine Synthesis and Releasementioning

confidence: 99%

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Vitamin D: A potent regulator of dopaminergic neuron differentiation and function

Pértile

Brigden

Raman

et al. 2023

Journal of Neurochemistry

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“…For instance, the group of Eyles observed an upregulation of miR-181c-5p that suppressed neurite outgrowth of DA neurons from the ventral mesencephalon. 122 These data suggested that miRNAs can be involved in the onset of psychological disorders such as schizophrenia. In addition, it has been shown that VD plays a role in the DNA methylation state in the germline and soma cells, suggesting a role of this mechanism in brain development.…”

Section: Discussionmentioning

confidence: 97%

Maternal vitamin D deficiency and brain functions: a never-ending story

Saidi,

Hammou,

Sicard

et al. 2023

Food Funct.

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“…Genomic regulation has epigenetic effects as it modifies the expression of enzymes involved in methylation and acetylation [65]. Additionally, micro-RNA (miR) expression that controls post-transcriptional gene expression and silencing is also controlled by this mechanism [66]. In short, calcitriol, VDREs, and modulators bound to the heterodimer-RXR are responsible for the physiological, genetic, and cell/tissue specificities, respectively.…”

Section: Genomic Action Of Calcitriolmentioning

confidence: 99%

Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease

Jeong,

Sharma,

2024

IJMS

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Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) buildup and neuronal degeneration. An association between low serum vitamin D levels and an increased risk of AD has been reported in several epidemiological studies. Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D, and is generated in the kidney and many other tissues/organs, including the brain. It is a steroid hormone that regulates important functions like calcium/phosphorous levels, bone mineralization, and immunomodulation, indicating its broader systemic significance. In addition, calcitriol confers neuroprotection by mitigating oxidative stress and neuroinflammation, promoting the clearance of Aβ, myelin formation, neurogenesis, neurotransmission, and autophagy. The receptors to which calcitriol binds (vitamin D receptors; VDRs) to exert its effects are distributed over many organs and tissues, representing other significant roles of calcitriol beyond sustaining bone health. The biological effects of calcitriol are manifested through genomic (classical) and non-genomic actions through different pathways. The first is a slow genomic effect involving nuclear VDR directly affecting gene transcription. The association of AD with VDR gene polymorphisms relies on the changes in vitamin D consumption, which lowers VDR expression, protein stability, and binding affinity. It leads to the altered expression of genes involved in the neuroprotective effects of calcitriol. This review summarizes the neuroprotective mechanism of calcitriol and the role of VDR polymorphisms in AD, and might help develop potential therapeutic strategies and markers for AD in the future.

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Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development

Cited by 8 publications

References 53 publications

Vitamin D: A potent regulator of dopaminergic neuron differentiation and function

Vitamin D: A potent regulator of dopaminergic neuron differentiation and function

Maternal vitamin D deficiency and brain functions: a never-ending story

Role of Calcitriol and Vitamin D Receptor (VDR) Gene Polymorphisms in Alzheimer’s Disease

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