Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model

Ali, Asad; Vasileva, Svetlina; Langguth, Mia; Alexander, Suzanne; Cui, Xiaoying; Whitehouse, Andrew J. O.; McGrath, John J.; Eyles, Darryl W.

doi:10.3390/nu11051187

Cited by 37 publications

(44 citation statements)

References 82 publications

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“…On the molecular level, cellular processes like oxidative stress or neuroinflammation were shown to play a role in ASD [159], and they could present a potential contact point for vitamin D 3 . In line with the abovementioned link between ASD and vitamin D, a vitamin D-deficient rat model revealed broad behavioral similarities between vitamin D-deficient models and ASD-associated behavior [160]. Treatment of an ASD rat model with high-dose vitamin D revealed significant protective effects [161].…”

Section: Neuropsychiatric Diseasesmentioning

confidence: 59%

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Lauer¹,

Janitschke²,

Hartmann³

et al. 2020

Vitamin D Deficiency

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Approximately 90% of the elderly population in the western countries has at least a mild to moderate vitamin D hypovitaminosis. Besides the well-known function of vitamin D in calcium homeostasis, it has been recently found that several enzymes and receptors involved in its homeostasis are expressed in the nervous system and brain suggesting also an important role in the brain homeostasis. Interestingly, epidemiological and clinical studies found reduced vitamin D level associated with an increased risk of several neurodegenerative disorders. In this chapter, we focus on a potential link between vitamin D and Alzheimer's disease, Parkinson's disease, multiple sclerosis, prion disease, and motor neuron disease. Epidemiological studies were summarized, an overview of the known potential underlying pathomolecular mechanisms are given, and results from clinical studies dealing with vitamin D supplementation were presented. As an outlook, recent literature suggesting an impact of vitamin D on autism spectrum disease, depression, and schizophrenia are briefly discussed. In conclusion, the identification of an abundant vitamin D metabolism in the brain and the tight link between the increasing number of several neurological and mental disorders emphasize the need of further research making a clear recommendation of the intake and supplementation of vitamin D in a growing elderly population.

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Section: Neuropsychiatric Diseasesmentioning

confidence: 59%

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Lauer¹,

Janitschke²,

Hartmann³

et al. 2020

Vitamin D Deficiency

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“…Previous findings regarding social behavior in the 3-chamber apparatus in DVD-deficient rats are mixed. Although we have also shown alterations in social play behavior in DVD-deficient rats as juveniles, when using the 3-chamber apparatus, we again could find no social approach or memory deficit in rats deprived of vitamin D until weaning when assessed as adults [39]. This is in contrast to findings from another group who also deprived male rats of vitamin D until weaning, and who showed a small but significant reduction in social approach using the 3-chamber apparatus (Social memory was not tested) [31].…”

Section: Discussionmentioning

confidence: 86%

Developmental Vitamin D Deficiency in the Rat Impairs Recognition Memory, but Has No Effect on Social Approach or Hedonia

Overeem

Schmeißer

et al. 2019

Nutrients

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Developmental vitamin D (DVD) deficiency is a risk factor for schizophrenia. In rodents we show that DVD-deficiency alters brain development and produces behavioral phenotypes in the offspring of relevance to the positive symptoms of schizophrenia. The aims of this study are to examine behavioral phenotypes specific to the cognitive and negative symptoms of schizophrenia in this model, and to vary the duration of vitamin D deficiency during gestation and beyond birth. We hypothesize that a longer duration of DVD-deficiency would result in greater behavioral impairments. Female vitamin D-deficient Sprague Dawley dams were mated at 10 weeks of age. Dietary vitamin D was reintroduced to dams and/or pups at different developmental time-points: Conception, Birth, Post-natal day (PND) 6 and PND21. Adult male and female offspring were assessed on a battery of behavioral tests, including sucrose preference, open field, novel object recognition (NOR), social approach and social novelty. We find that all windows of DVD-deficiency impaired NOR a cognitive measure that requires intact recognition memory. Sucrose consumption, social approach and social memory negative symptom-like phenotypes were unaffected by any maternal dietary manipulation. In addition, contrary to our hypothesis, we find that rats in the Conception group, that is the shortest duration of vitamin D deficiency, demonstrate increased locomotor activity, and decreased interaction time with novel objects. These findings have implications for the increasing number of studies examining the preclinical consequences of maternal vitamin D deficiency, and continue to suggest that adequate levels of maternal vitamin D are required for normal brain development.

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“…Finally, the behavior of offspring born to VD-deficient animals is similar to that of autistic young children (43). Interestingly, the timing of VD deficiency may be important to see/not to see ASD relevant phenotypes in rodents, and supplementation may have an impact on mouse models of ASD (44)(45)(46).…”

Section: Vitamin D Deficiency In Animals Causes Brain Structural and mentioning

confidence: 99%

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

Principi

Esposito

2020

Front. Psychiatry

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Autism spectrum disorder is a neurodevelopmental disorder characterized by reduced social interactions, impaired communications, and stereotypic and repetitive behavior with different degrees of severity. The etiology of autism spectrum disorder is unknown, although the interaction of genetic and environmental factors is believed to play a fundamental role in the process. The main aim of this narrative review is to discuss the current knowledge about the interrelationships between vitamin D deficiency during pregnancy and autism spectrum disorder development. Literature analysis showed that vitamin D supplementation during pregnancy plays a role in conditioning the development and function of the nervous system. Studies carried out in vitro and in experimental animals have shown that vitamin D deficiency can be associated with structural and functional abnormalities of the nervous system that can be observed in autism spectrum disorder patients. Moreover, it has been reported that vitamin D deficiency during pregnancy could be a risk factor for autism spectrum disorder development in the offspring, that children with autism spectrum disorder have significantly lower serum levels of vitamin D than normal children and that supplementation of vitamin D in autism spectrum disorder children is associated with a reduction in psychiatric manifestations. However, the data currently available do not adequately support the hypothesis that vitamin D may be a factor which contribute to the etiology of autism spectrum disorder. The effects of vitamin D supplementation during pregnancy should be better studied to establish whether and when fetal vulnerability is highest and if vitamin D supplementation is able to reduce the risk of structural and functional alterations of the nervous system and autism spectrum disorder development. The role of vitamin D after birth must be better defined to evaluate if vitamin D administration is potentially effective in reducing autism spectrum disorder manifestations.

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Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model

Cited by 37 publications

References 82 publications

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

The Effects of Vitamin D Deficiency on Neurodegenerative Diseases

Developmental Vitamin D Deficiency in the Rat Impairs Recognition Memory, but Has No Effect on Social Approach or Hedonia

Vitamin D Deficiency During Pregnancy and Autism Spectrum Disorders Development

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