There are increasing problems (real and perceived) associated with the handling of pesticides in agriculture. All known data reveal that the greatest levels of exposure encountered with the use of a pesticide occurs at the mixer-loader stage. LPCAT and Merck initiated a collaborative, designed laboratory and field study to evaluate the potential of a series of dissolvable bags for use in boom and airblast sprayers. In laboratory studies, the effect of temperature on bag dissolution was a non-linear inverse relationship. Water hardness had no effect on bag dissolution. The field tests included mechanical and by-pass agitation sprayers with numerous concentration spray volumes. The protocols included: variation in tank levels prior to the addition of bags, check points at suction strainers, and in-line filter and nozzle strainer observations at 10 min, 1 h, and 4 h, including 1 h down time. The QSA 2004 bag reduced foaming of the wettable powder formulation. The QSA 2000, 2004, and Monosol 8000 were successful in low volume tank mixes in hydraulic and mechanized agitation sprayers.