Developments in research on the nutritional health-promoting properties of three traditional leafy vegetables commonly consumed in sub-Saharan Africa

Moussa, Modoukpè I. Djibril; Alashi, Adeola M.; Sossa-Vihotogbe, C.N.A.; Baco, Mohamed Nasser; Djenontin, A.J.; Aluko, Rotimi E.; Akissoé, Noël H.

doi:10.1016/j.hermed.2023.100668

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Plant drugs are frequently considered less toxic and side effects free than synthetic ones [4]. Green leafy vegetables are widely used for nutritional and medicinal purposes [5]. Portulaca oleracea L. (purslane), Portulacaceae, is an annual herb.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Green Vegetable Leaf Powders in Diabetic Rats

Helmy,

Morsy,

Elaby

et al. 2023

Egypt. J. Chem.

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This study investigated the anti-diabetic effects of purslane (PS), chard (CA), and chicory (CI) leaf powders on streptozotocin (STZ)-induced type 2 diabetic rats. The total polyphenols, flavonoids and polyphenolic profiles were determined in the leaf powders. Thirty adult male albino rats were divided equally into six groups: untreated non-diabetic control was considered negative control. Other rat groups were rendered diabetic (fasting blood glucose (FBG) level >250 mg/dL) with a twice intraperitoneal injection of STZ (35 mg⁄kg). Diabetic rats were fed a basal diet. They were classified into five groups: a diabetic control group (positive control), a group receiving metformin (100 mg/kg body weight) as a medication, and other groups were fed a basal diet supplemented with either PS, CA, or CI leaf powder at a 1% level. The experiment lasted for 40 days. Blood samples were analyzed for FBG, insulin, fructosamine and oral glucose tolerance test (OGTT). Feeding diabetic rats basal diet containing the investigated leaf powders decreased insulin resistance (HOMA-IR,) significantly compared to diabetic rats. The CI and PS leaf powders displayed powerful positive hypoglycemic action compared to metformin, in addition to reversing the histological abnormalities in the liver and pancreas of diabetic rats to a state close to normal. Therefore, the investigated leaves may help reduce the metabolic syndrome associated with type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Green Vegetable Leaf Powders in Diabetic Rats

Helmy,

Morsy,

Elaby

et al. 2023

Egypt. J. Chem.

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Gamma irradiation green synthesis of (polyacrylamide/chitosan/silver nanoparticles) hydrogel nanocomposites and their using as antifungal against Candida albicans and anti-cancer modulator

Khalil,

Awadallah-F,

Khaffaga

et al. 2024

Sci Rep

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Silver nanoparticles-loaded hydrogel nanocomposites are exploited for medicinal and pharmaceutical applications. Hydrogel nanocomposites were prepared from acrylamide (Am), chitosan (CS) and AgNO3 utilizing gamma rays. Diverse variables were applied in preparation of silver nanoparticles-laoded hydrogel nanocomposites of (PAm/CS)-AgNPs such as influence of radiation dose and influnece of CS concentration. Diverse techniques were utilized to characterize hydrogel nanocomposites; Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Transmission electron microscopy (TEM), energy dispersive X-ray (EDX) and scanning electron microscopy (SEM). Results confirmed formation of silver nanoparticles-loaded hydrogel nanocomposites of (PAm/CS)-AgNPs. Antifungal activity of (PAm/CS)-AgNPs hydrogel nanocomposites on viability of C. albicans was esitmated. Results displayed the efficient microbial inhibition activity of treatment against C. albicans compared to control. Furthermore, (PAm/CS)-AgNPs hydrogel nanocomposite against cervical cancer HeLa cell line was investigated. Cytotoxicity of (PAm/CS)-AgNPs hydrogel nanocomposites on prior cancer cell line empolyed to prohibition of cell growth assesssed by MTT test. HeLa cancer cell is treated by (PAm/CS)-AgNPs for 48 h exposed a potential apoptotic activity by noticeable up-regulation of p53 gene expression. Moreover, anticancer activity was investigated by down-regulation of platelet-based growth variable receptor beta (PDGFR-β), Bcl2, Cathepsine, and MMP-2 gene expression. antioxidant activity was investigated and results showed antioxidant activity of (PAm/CS) hydrogel and (PAm/CS)-AgNPs hydrogel nanocomposite are 87.8% and 62.9%, respectively.

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Developments in research on the nutritional health-promoting properties of three traditional leafy vegetables commonly consumed in sub-Saharan Africa

Cited by 2 publications

References 22 publications

Antidiabetic Effect of Green Vegetable Leaf Powders in Diabetic Rats

Antidiabetic Effect of Green Vegetable Leaf Powders in Diabetic Rats

Gamma irradiation green synthesis of (polyacrylamide/chitosan/silver nanoparticles) hydrogel nanocomposites and their using as antifungal against Candida albicans and anti-cancer modulator

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