Developments in the systemic treatment of metastatic cervical cancer

Mountzios, Giannis; Soultati, Aspasia; Pectasides, Dimitrios; Pectasides, Eirini; Dimopoulos, Meletios Α.; Papadimitriou, Christos

doi:10.1016/j.ctrv.2012.05.009

Cited by 30 publications

(24 citation statements)

References 129 publications

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“…This is most likely due to practical reasons, as this procedure was better implemented in the operation room context during primary surgical treatment. Still, patients with high FIGO stages are presently in a particular need for more targeted and effective treatment options [14]. Thus, studies of molecular profiling of fresh frozen primary lesions may benefit from addressing logistic obstacles related to inclusions of patients with FIGO stages III and IV disease.…”

Section: Variablesmentioning

confidence: 99%

Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix

Halle

Krakstad

Engerud

et al. 2014

Pathology - Research and Practice

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Section: Variablesmentioning

confidence: 99%

Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix

Halle

Krakstad

Engerud

et al. 2014

Pathology - Research and Practice

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“…There is a general consensus that regular screening is the most important public health strategy for reducing the incidence of cervical cancer and the subsequent mortality [13]. The main strategy used for the early detection of cervical cancer in Brazil is screening, which entails performance of the preventive exam, i.e.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of High-Grade Intraepithelial Neoplasia in Patients with Cytology Presenting Atypical Squamous Cells of Undetermined Significance

Lopes¹,

Campaner²,

Henrique³

2016

Acta Cytologica

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Objectives: To evaluate the prevalence of histological high-grade lesions and cervical cancer in patients with ASCUS cytology. Methods: This is a cross-sectional prospective study involving 703 women with a uterus and atypical squamous cells of undetermined significance (ASCUS). The patients were submitted to a colposcopy and underwent a guided biopsy when changes on the colposcopy were detected. Results: The findings revealed 456 (64.9%) women with a normal colposcopy and 247 (35.1%) with colposcopic abnormalities. The biopsy results were: cervical intraepithelial neoplasia grade 1 (CIN 1) in 51 (20.6%) patients, CIN 2 in 11 (4.5%) patients, CIN 3 in 8 (3.2%) patients, and a negative result in 177 (71.7%) patients; no cases of cancer were detected. Tallying of 456 normal colposcopies and 177 negative biopsies yielded a total of 90.04% negative exams. Furthermore, around 7.2% (51/703) of the patients exhibited CIN 1, a lesion associated with a high potential for regression. The biopsy results were not associated with patient age or menopausal status. Conclusion: We conclude that cytological surveillance of patients with ASCUS is feasible and safe given the low risk of CIN 2/3 or cervical cancer.

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“…It is a significant challenge to develop effective detection strategies and target treatment for the cancer cells (Mountzios et al, 2013). Here, a novel approach to perform electrochemical study of leukemia K562 cells on a home-made analytical device using ITO as the low cost and simple electrode material is presented.…”

Section: Introductionmentioning

confidence: 99%

A new disposable electrode for electrochemical study of leukemia K562 cells and anticancer drug sensitivity test

Zhu

Wang

et al. 2014

Biosensors and Bioelectronics

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Developments in the systemic treatment of metastatic cervical cancer

Cited by 30 publications

References 129 publications

Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix

Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix

Prevalence of High-Grade Intraepithelial Neoplasia in Patients with Cytology Presenting Atypical Squamous Cells of Undetermined Significance

A new disposable electrode for electrochemical study of leukemia K562 cells and anticancer drug sensitivity test

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