Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Shaw, Dana K.; McClure, Erin E.; Wang, Xiaowei; Pedra, Joao H. F.

doi:10.3390/vetsci3040027

Cited by 8 publications

(5 citation statements)

References 277 publications

(303 reference statements)

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“…As a result, increased attention has been given to the exploration of deviant innovation mechanisms and influencing factors. At present, research on employees’ deviant innovation behavior focus more on its destructive aspect ( Shaw et al, 2016 ). Some scholars suggest that deviant behavior, based on promoting the healthy development of the organization, could significantly improve performance ( Shoaib and Baruch, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Entrepreneurs’ Psychological Capital on Their Deviant Innovation Behavior

Wen-hai

Zhao

2020

Front. Psychol.

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This study explores the influence of psychological capital on the deviant innovation behavior, with the purpose of realizing the application and development of positive psychology in the field of innovation and creation. First, the data was obtained based on the questionnaire, and the Likert scale was adopted to measure the variables effectively, in which 1 point means “never,” 2 points mean “rarely,” and 5 points mean “always.” Second, the SPSS 26.0 statistical analysis software was adopted, and a statistical analysis was made on the correlation among deviant innovation, psychological capital, work values, and work remodeling. Third, the relationship between psychological capital and deviant innovation behavior was explored using the analytic hierarchy process (AHP). The results showed that the reliability of each scale is good, Cronbach’s α coefficients are all higher than 0.8, and the fitting effect of the four-factor model is the best, proving that the highest differentiation validity can be achieved using the proposed method. Furthermore, there are significant correlations among entrepreneur’s psychological capital, entrepreneur’s work values, and entrepreneurship work remodeling and deviant innovation behavior, among which the psychological capital and work values are the most correlated with deviant innovation. With the psychological capital of entrepreneurs as the adjustment variable and the interaction added, the explanation rate of the level equation is increased from 17 to 24.2%. Therefore, the psychological capital of entrepreneurs plays a very big role in regulating work values and deviant innovation behavior. In the current environment of innovation and entrepreneurship development, it is necessary for entrepreneurs to give full reign to the regulatory role of their own psychological capital, so as to promote the development of self-active deviant innovation activities and encourage employees to actively innovate and create.

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Section: Introductionmentioning

confidence: 99%

The Influence of Entrepreneurs’ Psychological Capital on Their Deviant Innovation Behavior

Wen-hai

Zhao

2020

Front. Psychol.

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“…TLRs are specific pattern recognition receptors that are used to identify various unique components of prokaryotes, fungi and pathogens, and the TLR signaling pathway plays an important role in the initiation of innate immunity [ 54 , 55 ]. NLRs, also part of the pattern recognition receptor subfamily, promote the inflammasome pathway (cytoplasmic signaling devices that activate caspase-1, IL-1β and IL-18), which can increase regulation of the immune response to pathogens and damaged self-molecules, as well as tissue repair [ 56 , 57 , 58 ]. The MAPK and NF-κB pathways both belong to the downstream signaling pathways of TLR and NLR, which can be stimulated and activated by TLRs and NLRs, thus increasing the expression of pro-inflammatory factors (e.g., IL-1β, TNF-α, CXCL8 and IL-12) and inducing inflammation [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Immunotoxicity and Transcriptome Analyses of Zebrafish (Danio rerio) Embryos Exposed to 6:2 FTSA

Zhang

Ren

Chen

2023

Toxics

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As a new alternative to perfluorooctane sulfonic acid (PFOS), 6:2 fluorotelomer sulfonic acid (6:2 FTSA) has been widely produced and used in recent years, and its concentration and frequency of detection in the aquatic environment and aquatic organisms are increasing. However, studies of its toxicity in aquatic biological systems are alarmingly scarce, and the relevant toxicological information needs to be improved. In this study, we investigated AB wild-type zebrafish (Danio rerio) embryos subjected to acute 6:2 FTSA exposure for immunotoxicity using immunoassays and transcriptomics. Immune indexes showed significant decreases in SOD and LZM activities, but no significant change in NO content. Other indexes (TNOS, iNOS, ACP, AKP activities, and MDA, IL-1β, TNF-α, NF-κB, TLR4 content) all showed significant increases. These results indicated that 6:2 FTSA induced oxidative stress and inflammatory responses in zebrafish embryos and exhibited immunotoxicity. Consistently, transcriptomics showed that genes involved in the MAPK, TLR and NOD-like receptor signaling pathways (hsp70, hsp701, stat1b, irf3, cxcl8b, map3k8, il1b, tnfa and nfkb) were significantly upregulated after 6:2 FTSA exposure, suggesting that 6:2 FTSA might induce immunotoxicity in zebrafish embryos through the TLR/NOD-MAPK pathway. The results of this study indicate that the safety of 6:2 FTSA should be examined further.

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“…The innate immune signalling structures, the so called innate immune sensors, include Toll-like receptors (TLRs), Nod-like receptors (NLR), absent in myeloma (AIM2), C-type lectin receptors, retinoid acid-inducible gene I-like receptors (RIG I-like) and cyclic GMP-AMP synthase (cGAS)/STING (stimulator of interferon genes) [26,27]. The best analyzed pathways are those activated from TLR and NLR receptors, which localize and respond to antigens either on membrane surface or inside the cells, respectively [28].…”

Section: Inflammasomes As Key Multimolecular Mechanisms Reacting To Imentioning

confidence: 99%

Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts

Torina

Villari

Blanda

et al. 2020

IJMS

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Many pathogens are transmitted by tick bites, including Anaplasma spp., Ehrlichia spp., Rickettsia spp., Babesia and Theileria sensu stricto species. These pathogens cause infectious diseases both in animals and humans. Different types of immune effector mechanisms could be induced in hosts by these microorganisms, triggered either directly by pathogen-derived antigens or indirectly by molecules released by host cells binding to these antigens. The components of innate immunity, such as natural killer cells, complement proteins, macrophages, dendritic cells and tumor necrosis factor alpha, cause a rapid and intense protection for the acute phase of infectious diseases. Moreover, the onset of a pro-inflammatory state occurs upon the activation of the inflammasome, a protein scaffold with a key-role in host defense mechanism, regulating the action of caspase-1 and the maturation of interleukin-1β and IL-18 into bioactive molecules. During the infection caused by different microbial agents, very similar profiles of the human innate immune response are observed including secretion of IL-1α, IL-8, and IFN-α, and suppression of superoxide dismutase, IL-1Ra and IL-17A release. Innate immunity is activated immediately after the infection and inflammasome-mediated changes in the pro-inflammatory cytokines at systemic and intracellular levels can be detected as early as on days 2–5 after tick bite. The ongoing research field of “inflammasome biology” focuses on the interactions among molecules and cells of innate immune response that could be responsible for triggering a protective adaptive immunity. The knowledge of the innate immunity mechanisms, as well as the new targets of investigation arising by bioinformatics analysis, could lead to the development of new methods of emergency diagnosis and prevention of tick-borne infections.

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Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling

Cited by 8 publications

References 277 publications

The Influence of Entrepreneurs’ Psychological Capital on Their Deviant Innovation Behavior

The Influence of Entrepreneurs’ Psychological Capital on Their Deviant Innovation Behavior

Immunotoxicity and Transcriptome Analyses of Zebrafish (Danio rerio) Embryos Exposed to 6:2 FTSA

Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts

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