Device-associated infections in the intensive care units of Cyprus: results of the first national incidence study

Gikas, Achilleas; Roumbelaki, Maria; Bagatzouni-Pieridou, D.; Alexandrou, Maria Eleni; Zinieri, V.; Dimitriadis, Ioannis; Kritsotakis, Evangelos I.

doi:10.1007/s15010-010-0007-2

Cited by 18 publications

(25 citation statements)

References 27 publications

(38 reference statements)

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“…The total number of DA-HAIs instances in the third phase (2017), were 87% lower compared to the baseline. In fact DA-HAI incidence rates, especially at the third surveillance period (2017), were much lower than the majority of published literature [8,[37][38][39][40]. After the adjustment for the number of patients, our results confirmed the progressive reduction in both two years that in 2017 was statistically significant.…”

Section: Discussionsupporting

confidence: 74%

“…Our interventions resulted to a significant decrease in CLABSI rates from 15.9/1000DD (2015), to 4.2/1000DD (2016) and then to 1.95/1000DD during the 2017 surveillance period (phase three). The absolute 2017 rate appears to be lower than the majority of the reported published literature [5,8,36,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60]. By the beginning of the next period (2016), our efforts resulted to a significant decrease in CLABSI rates from 15.9/1000DD (2015), to 4.2/1000DD (2016) and then to 1.95/1000DD during the 2017 surveillance period (phase three).…”

Section: Discussionmentioning

confidence: 78%

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The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Iordanou¹,

Middleton²,

Papathanassoglou³

et al. 2019

Preprint

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Background: Device-associated health care-associated infections (DA-HAIs) are a major threat to patient safety, particularly in the Intensive Care Unit (ICU). The aim of this study was to evaluate the effectiveness of a bundle of infection control measures to reduce DA-HAIs in the ICU of a General Hospital in the Republic of Cyprus, over a three-year period. Methods: We studied 599 ICU patients with length of stay (LOS) for at least 48 hours. Our prospective cohort study was divided into three surveillance phases. VAP, CLABSI, and CAUTI incidence rates, LOS and mortality were calculated before, during and after the infection prevention and control program. Results: There was a statistically significant reduction in the number of DA-HAI events during the surveillance periods, associated with DA-HAIs prevention efforts. In 2015 (prior to program implementation), the baseline DA-HAIs instances were 43: 16 VAP (10.1/1000 Device Days), 21 (15.9/1000DD) CLABSIs and 6 (2.66/1000DD) CAUTIs, (n=198). During the second phase (2016), CLABSIs prevention measures were implemented and the number of infections were 24: 14 VAP (12.21/1000DD), 4 (4.2/1000DD) CLABSIs & 6 (3.22/1000DD) CAUTIs, (n=184). During the third phase (2017), VAP and CAUTI prevention measure were again implemented and the rates were 6: (3 VAP: 12.21/1000DD), 2 (1.95/1000DD) CLABSIs & 1 (0.41/1000DD) CAUTIs, (n=217). There was an overall reduction of 87% in the total number of DA-HAIs instances for the period 01/01/15 to 31/12/17. Conclusions: The significant overall reduction in DA-HAI rates, indicates that a comprehensive infection control program can affect DA-HAI rates.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 78%

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Iordanou¹,

Middleton²,

Papathanassoglou³

et al. 2019

Preprint

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“…The overall resistance rate to ciprofloxacin observed in the present study was similar to that reported by NNISS but lower than the rate reported by INICC. Gikas et al (17) reported a 22z resistance rate of P. aeuruginosa to ciprofloxacin, whereas Leblebicioglu et al (16) found a rate of 51.1z from the evaluation of 13 ICUs in Turkey.…”

Section: Discussionmentioning

confidence: 99%

Device-Associated Nosocomial Infection Rates and Distribution of Antimicrobial Resistance in a Medical-Surgical Intensive Care Unit in Turkey

Tigen

Doğru

Koltka³

et al. 2014

Jpn J Infect Dis

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SUMMARY:The aim of this study was to explore the rate of device-associated nosocomial infections (DANIs) and the distributions of causative agents and patterns of antibiotic resistance in the medicalsurgical intensive care unit (ICU) over a 3-year period and to compare these rates with those reported by National Nosocomial Infections Surveillance System and International Nosocomial Infection Control Consortium. A total of 1,798 patients were hospitalized in our ICU for 13,942 days, of which 309 patients had DANIs, indicating an overall infection rate of 22.1 per 1,000 ICU-days. The central lineassociated bloodstream infection rate was 6.4 per 1,000 catheter-days, whereas the ventilator-associated pneumonia rate was 14.3 per 1,000 ventilator-days and the catheter-associated urinary tract infection rate was 4.3 per 1,000 catheter-days. Overall, 87.4z of all Staphylococcus aureus DANIs were caused by methicillin-resistant strains. With respect to Pseudomonas aeruginosa, 30.9z of the strains were resistant to ciprofloxacin, 23.3z to amikacin, 43.1z to ceftazidime, 19.1z to piperacillin-tazobactam, and 34.7z to imipenem. Furthermore, 1.9z of the Enterococcus spp. were resistant to vancomycin, and 51.1z of Enterobacteriaceae were resistant to ceftriaxone. DANI rates decreased over the 3-year study period, which was likely in response to the infection control measures implemented in our ICU.

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“…It unfortunately, indicates too rare application of the capabilities of contemporary microbiology in everyday clinical practice of the studied NICUs. This is confirmed by the results of a Cypriot study, in which LC-BSI constituted 96% of all BSIs [23]. Another matter is the debated problem of legitimacy of repeated blood drawing for cultures from VLBW newborns.…”

Section: Discussionmentioning

confidence: 65%

Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland

Różańska

Wójkowska‐Mach

Adamski

et al. 2017

Ann Clin Microbiol Antimicrob

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BackgroundNewborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usage in bloodstream infections treatment in the Polish Neonatology Surveillance Network (PNSN) and determining the possibility of applying this kind of data in infection control, especially for the evaluation of standard methods of microbiological diagnostics.MethodsData were collected between 01.01.2009 and 31.12.2013 in five teaching NICUs from the PNSN. The duration of treatment in days (DOT) and the defined daily doses (DDD) were used for the assessment of antibiotics consumption.ResultsThe median DOT for a single case of BSI amounted to 8.0 days; whereas the median consumption expressed in DDD was 0.130. In the case of laboratory confirmed BSI, median DOT was 8 days, and consumption—0.120 DDD. Median length of therapy was shorter for unconfirmed cases: 7 days, while the consumption of antibiotics was higher—0.140 DDD (p < 0.0001). High consumption of glycopeptides expressed in DOTs was observed in studied population, taking into account etiology of infection.ConclusionsEven application of classical methods of microbiological diagnostics significantly reduces the consumption of antibiotics expressed by DDD. However, the high consumption of glycopeptides indicates the necessity of applying rapid diagnostic assays. Nevertheless, the assessment of antibiotic consumption in neonatal units represents a methodological challenge and requires the use of different measurement tools.

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Device-associated infections in the intensive care units of Cyprus: results of the first national incidence study

Cited by 18 publications

References 27 publications

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Device-Associated Nosocomial Infection Rates and Distribution of Antimicrobial Resistance in a Medical-Surgical Intensive Care Unit in Turkey

Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland

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