Devolution in the United Kingdom

Deacon, Russell; Sandry, Alan

doi:10.1515/9780748669714

Cited by 12 publications

(2 citation statements)

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“…Using the formula, 1.96 = (difference, %)/(√3 2 + 3 2 ), an 8% difference was considered significant at a confidence interval of 95% ( P = 0.05). 4 The reporting format for this testing is to report whole numbers, however, the calculations were performed on concentrations that include one decimal place (data not shown). For samples with nondetectable prepreparation isopropanol, a significant difference was calculated using 4.9 mg/dL because that is the highest possible concentration of isopropanol that would be reported as <5 mg/dL.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Donor Preparation for Tissue Procurement on Postmortem Vitreous Isopropanol Concentration

Avedschmidt

Melton

Turner

et al. 2023

Am J Forensic Med Pathol

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Volatile chemicals can be relevant in the determination of the cause and manner of death by forensic pathologists. Isopropanol is a secondary alcohol that is occasionally seen on postmortem toxicology testing. A series of 11 forensic autopsy cases was previously reported in which the presence of isopropanol in the vitreous humor was suspected to be due to postmortem contamination from the body preparation process for tissue procurement.In collaboration with a tissue procurement agency, donor vitreous humor was collected from one eye before body preparation for procurement and from the other eye postpreparation. The specimens underwent testing for volatile substances by headspace gas chromatography.Of the 50 cases, 8 (16%) showed statistically significant changes in the prepreparation and postpreparation isopropanol concentrations. Postpreparation isopropanol concentrations ranged from 5 to 104 mg/dL (median, 18 mg/dL). Seven of the 8 cases had undetectable prepreparation isopropanol, whereas the remaining case had a detectable prepreparation isopropanol.In conclusion, surface contamination of the decedent's body with chemicals used in body preparation can lead to the passive absorption into the body, resulting in the presence of isopropanol in postmortem toxicology samples. Forensic pathologists need to be aware of this when interpreting postmortem samples after tissue procurement.

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Section: Methodsmentioning

confidence: 99%

The Impact of Donor Preparation for Tissue Procurement on Postmortem Vitreous Isopropanol Concentration

Avedschmidt

Melton

Turner

et al. 2023

Am J Forensic Med Pathol

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“…Instead of calculating rates of cell shape change and translation over time (per min), here we calculated these quantities over depth (per z µm) (Fig. 4S2c, e) (Deacon, 2012;Sanchez-Corrales et al, 2018). The unit of wedging is proportional size change per mm in z, and tilt is a vector gradient (xy mm/z mm).…”

Section: Calculating 3d Cell Tilt and Cell Wedging Between Aj And Sub...mentioning

confidence: 99%

Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions

Blanchard

Scarpa

Mureşan

et al. 2023

Preprint

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The orientation of cell division (OCD) in the plane of epithelia drives tissue morphogenesis and relaxes stresses, with errors leading to pathologies. Stress anisotropy, cell elongation and planar polarisation can all contribute to the OCD, but it is unclear how these interact in vivo. In the planar polarised Drosophila embryonic ectoderm during axis elongation, planar OCD is highly variable. We show that both a temporary reversal of tissue stress anisotropy and local compression from neighbouring dividing cells re-orient mitotic spindles during metaphase, independently of interphase cell elongation. Isotropic cells align their OCD to the anterior-posterior (AP) embryonic axis, mediated by tissue-wide planar polarised Myosin II, while the spindle of elongated cells is sterically constrained to cell long axes. Thus AP-patterning ensures that cell division combines with cell rearrangement to extend the body axis, except when strong local stress anisotropy is dissipated by cells dividing according to their elongation.

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Common Legal Thinking in European Constitutionalism: Some Reflections

Arnold

2015

Common European Legal Thinking

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Devolution in the United Kingdom

Cited by 12 publications

References 0 publications

The Impact of Donor Preparation for Tissue Procurement on Postmortem Vitreous Isopropanol Concentration

The Impact of Donor Preparation for Tissue Procurement on Postmortem Vitreous Isopropanol Concentration

Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions

Common Legal Thinking in European Constitutionalism: Some Reflections

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