Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance

Taylor‐Robinson, David; Maayan, Nicola; Soares‐Weiser, Karla; Donegan, Sarah; Garner, Paul

doi:10.1002/14651858.cd000371.pub4

Cited by 146 publications

(216 citation statements)

References 104 publications

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“…The delivery of anthelminthics through schools has lately been the intervention of choice for reducing STH infections in children. The effectiveness of these programmes, especially with respect to improving cognitive performance, has recently been questioned, however, a large meta-analysis did not find a significant improvement,39 underscoring the need to interrupt transmission via effective sanitation in home and school environments 40…”

Section: Transmission Routes and Health Impactmentioning

confidence: 99%

Water, sanitation, hygiene and enteric infections in children

Brown

Cairncross

Ensink

2013

Archives of Disease in Childhood

226

161

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Section: Transmission Routes and Health Impactmentioning

confidence: 99%

Water, sanitation, hygiene and enteric infections in children

Brown

Cairncross

Ensink

2013

Archives of Disease in Childhood

226

161

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“…2,[17][18][19] Similar results from early studies suggested that MDA decreases intensity and prevalence of infection over time, 2 although a recent Cochrane review concluded that there is limited evidence of consistent effects of MDA on nutrition and cognition among school children. 20 This recent suggestion that the benefits of school based deworming may be overstated has generated significant dialogue regarding the potential for MDA to control geohelminth infections globally.…”

Section: Introductionmentioning

confidence: 99%

Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment

Humphries¹,

Simms²,

Davey³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Children (n = 812) 6-11 years of age attending 16 schools in the Kintampo North Municipality of Ghana were screened for participation in a study on hookworm infection, nutrition, and response to albendazole. The prevalence of Necator americanus hookworm infection (n = 286) was 39.1%, and significant predictors of infection included age, malaria parasitemia, lack of health care, school area, levels of antibodies against hookworm, and low consumption of animal foods. The cure rate after a single dose (400 mg) albendazole was 43%, and the mean fecal egg count reduction rate was 87.3%. Data for an in vitro egg hatch assay showed a trend toward reduced albendazole susceptibility in post-treatment hookworm isolates (P = 0.06). In summary, hookworm infection is prevalent among school age children in the Kintampo North Municipality and animal food intake inversely correlates with infection status. Modest cure rates and fecal egg count reduction rates reinforce the need for further investigation of potential benzimidazole resistance in Ghana.

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“…91 A recent review found that deworming interventions have a positive impact on child growth. 92,93 However, pooled analyses did not demonstrate clear evidence of an effect of deworming on cognition, although some individual studies did. [94][95][96] The inability of some studies to detect developmental gains might relate to methodological limitations; more well-designed trials are therefore needed to assess the impact of deworming on children's cognitive development.…”

Section: Childhood Health Interventionsmentioning

confidence: 96%