Dexamethasone decreases the duration of rocuronium-induced neuromuscular block

Abstract

ClinicalTrial.gov Identifier: NCT01782820.

Dexamethasone Does Not Inhibit Sugammadex Reversal After Rocuronium-Induced Neuromuscular Block

“…Chen et al 16 demonstrated that chronic dexamethasone treatment induced an alteration in fiber composition in the rat diaphragm leading to desensitization to rocuronium. Soltész et al 17 evaluated the effect of a single 8-mg dexamethasone dose on rocuronium neuromuscular block, and they found that IV administration 2 to 3 hours before recovery makes the reversal of rocuronium-induced neuromuscular block 15% to 20% shorter.…”

The Effect of Intravenous Dexamethasone on Sugammadex Reversal Time in Children Undergoing Adenotonsillectomy

“…It is clearly demonstrated that dexamethasone attenuates rocuronium-induced neuromuscular blockade when administered 2 to 3 hours before the induction of anesthesia. 33 However, when dexamethasone is given at induction, the duration of neuromuscular blockade is not affected. 33 In the present study, this was the main reason why we used dexamethasone at the induction of anesthesia.…”

“…33 However, when dexamethasone is given at induction, the duration of neuromuscular blockade is not affected. 33 In the present study, this was the main reason why we used dexamethasone at the induction of anesthesia.…”

Effect of dexamethasone on the onset time and recovery profiles of cisatracurium

“…For the prevention of PONV, dexamethasone is commonly injected prior to surgery at the induction of anesthesia, owing to its delayed onset [1617]. Recently, Soltesz et al [7] examined whether dexamethasone required more time to influence the time course of NMB by analyzing its interaction with rocuronium. They documented that a single-dose injection of 8 mg dexamethasone 2–3 h before surgery hastened the clinical duration, recovery index, and total recovery time, while injection administered 15 min prior to rocuronium administration did not attenuate the effect of rocuronium.…”

“…A recent study reported that a single dose of 8 mg dexamethasone showed different results in the time course of rocuronium, an aminosteroid non-depolarizing NMB, according to different injection time points. Dexamethasone (8 mg) injection administered 2–3 h before surgery hastened the clinical duration, recovery index, and total recovery time of rocuronium; however, dexamethasone injection immediately before the induction of anesthesia did not influence the time course of the NMB [7]. However, to date, no studies have been conducted on the effect of dexamethasone on the onset time and recovery profiles (clinical duration, recovery index, recovery time, and total recovery time) of cisatracurium, a benzylisoquinolium non-depolarizing NMB.…”