Dexamethasone for the Prophylaxis of Radiation-Induced Emesis: A National Cancer Institute of Canada Clinical Trials Group Phase III Study

Kirkbride, Peter; Bezjak, Andrea; Pater, Joseph L.; Zee, Benny; Palmer, Michael; Wong, Ralph; Cross, P.; Gulavita, Sunil; Blood, Paul; Sun, Alexander; Dundas, George; Ganguly, Pradip; Lim, Jihyun; Chowdhury, Anirban; Kumar, Satyam; Dar, A. Rashid

doi:10.1200/jco.2000.18.9.1960

Cited by 72 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Steroids such as dexamethasone are often used with chemotherapy and radiation treatments of patients to combat nausea and vomiting [102,103]. The therapeutic outcome of many solid tumors and cancers may be negatively impacted by glucocorticoid treatment depending on the type of cancer.…”

Section: Anti-apoptotic Effects Of Glucocorticoid Signalingmentioning

confidence: 99%

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Gruver-Yates

Cidlowski

2013

Cells

129

View full text Add to dashboard Cite

First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will focus on the established mechanisms of glucocorticoid-induced apoptosis and outline what is known about the apoptotic response in cells and tissues of the body after exposure to glucocorticoids. Glucocorticoid-induced apoptosis affects the skeletal system, muscular system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Interestingly, several cell types have an anti-apoptotic response to glucocorticoids that is cytoprotective. Lastly, we will discuss the pro- and anti-apoptotic effects of glucocorticoids in cancers and their clinical implications.

show abstract

Section: Anti-apoptotic Effects Of Glucocorticoid Signalingmentioning

confidence: 99%

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Gruver-Yates

Cidlowski

2013

Cells

129

View full text Add to dashboard Cite

show abstract

“…These hormones are also widely used in combination with chemotherapy and radiation of patients with solid tumours due to several other beneficial effects. Thus, GCs reduce nausea and emesis, protect healthy tissue from cytotoxic side-effects, and presumably reduce tissue reactions such as inflammation against invasive malignant growth (2,3).…”

Section: Introductionmentioning

confidence: 99%

Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma

et al. 2006

View full text Add to dashboard Cite

Glucocorticoids (GCs) such as dexamethasone (DEX) have been widely used as co-medication in cancer therapy because they have potent proapoptotic properties in lymphoid cells, can reduce nausea, and alleviate acute toxic effects in healthy tissue. However, GCs are used in a supportive-care role, even though no prospective clinical studies have assessed the effect of these steroids on the growth of solid tumours. Data from preclinical and, to some extent, clinical studies, suggest that GCs induce treatment resistance in some solid tumours. Since it is unknown whether GC-induced resistance occurs only occasionally or is a more common phenomenon, we performed a screening study using several established cell lines from bone, brain, breast and cervix carcinoma as well as melanoma and neuroblastoma together with fresh surgical resections from patients with breast cancer. We found that DEX inhibits cisplatin and 5fluorouracil-induced apoptosis and promotes the growth of the majority of examined malignant cells. In contrast, and as expected, DEX acted pro-apoptotically and promoted the cytotoxic effect of chemotherapy in established and primary lymphoid cells. Thus, these data demonstrate the need for detailed molecular studies to clarify the mechanism of differential glucocorticoid signaling as well as controlled, prospective clinical studies.

show abstract

“…However, over 30 years ago, the glucocorticoid dexamethasone was reported to be effective in preventing chemotherapy-induced nausea and vomiting12. Since that time, glucocorticoids have also been shown to prevent postoperative34 and radiotherapy-induced5 nausea and vomiting. Thus, glucocorticoids constitute one of the major classes of drugs that are considered first-line anti-emetic agents, together with 5HT 3 receptor antagonists, such as ondansetron, tachykinin NK 1 receptor antagonists, such as aprepitant, and dopamine D 2 receptor antagonists, such as metoclopramide6.…”

mentioning

confidence: 99%

Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential

Fietz

Keenan

López-Campos

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Glucocorticoids are commonly used to prevent chemotherapy-induced nausea and vomiting despite a lack of understanding of their direct effect on cancer progression. Recent studies suggest that glucocorticoids inhibit cancer cell migration. However, this action has not been investigated in estrogen receptor (ER)-negative breast tumour cells, although activation of the glucocorticoid receptor (GR) is associated with a worse prognosis in ER-negative breast cancers. In this study we have explored the effect of glucocorticoids on the migration of the ER-negative MDA-MB-231 human breast tumour cell line and the highly metastatic MDA-MB-231-HM.LNm5 cell line that was generated through in vivo cycling. We show for the first time that glucocorticoids inhibit 2- and 3-dimensional migration of MDA-MB-231 cells. Selection of cells for high metastatic potential resulted in a less migratory cell phenotype that was resistant to regulation by glucocorticoids and showed decreased GR receptor expression. The emergence of glucocorticoid resistance during metastatic selection may partly explain the apparent disparity between the clinical and in vitro evidence regarding the actions of glucocorticoids in cancer. These findings highlight the highly plastic nature of tumour cells, and underscore the need to more fully understand the direct effect of glucocorticoid treatment on different stages of metastatic progression.

show abstract

Dexamethasone for the Prophylaxis of Radiation-Induced Emesis: A National Cancer Institute of Canada Clinical Trials Group Phase III Study

Abstract: Dexamethasone 2 mg tid seems to be an effective prophylactic antiemetic in this situation. Side effects were acceptable, but there seemed to be no overall effect on global quality of life.

Cited by 72 publications

References 11 publications

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma

Glucocorticoid resistance of migration and gene expression in a daughter MDA-MB-231 breast tumour cell line selected for high metastatic potential

Contact Info

Product

Resources

About