Dexamethasone nonsuppression and short rapid eye movement latency in schizophrenia: Markers of an affective diathesis?

Goldman, Mona; Tandon, Rajiv; Taylor, Stephan F.; DeQuardo, John R.; Shipley, James E.; Patel, Bina; Reddig, Sara; Jibson, Michael D.

doi:10.1016/s0006-3223(96)89256-0

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Seven studies found a correlation of non-suppression with depression (Addington and Addington, 1990;Hwu et al, 1987;Ismail et al, 1998;Jones et al, 1994;Keshavan et al, 1988;Munro et al, 1984;Sawyer and Jeffries, 1984) while 15 did not (Aleem et al, 1988;Dewan et al, 1982;Doran et al, 1986;Garyfallos et al, 1993;Keshavan et al, 1989;Lu et al, 1988;Minas et al, 1990;Moller et al, 1986;Newcomer et al, 1991;Perenyi et al, 1987;Sharma et al, 1988;Tandon et al, 1991Tandon et al, , 1996Tsoi et al, 1986;Whiteford et al, 1988). Goldman et al (1996) found no association of non-suppression with a family history of depression.…”

Section: The Dexamethasone Suppression Test In Schizophreniamentioning

confidence: 99%

Review: A systematic review of hypothalamic-pituitary-adrenal axis function in schizophrenia: implications for mortality

2010

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There is convincing evidence that environmental stress plays a significant role in modifying both mental and physical health. The biological mechanisms linking stress to ill health are not fully understood, but significant evidence points to a central role of the stress axes; the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic nervous system. Together these two systems link the brain and the body and are crucial in maintaining homeostasis as well as improving an organism’s survival chances in the face of environmental challenge. There is evidence of altered HPA axis function in people with a range of mental disorders, and this may in part explain the poor physical health of people with psychotic, mood and anxiety disorders. This paper systematically reviews HPA axis function in people with schizophrenia and relates this to the pattern of physical health seen in this disease. In summary, the evidence suggests people with schizophrenia can experience both hyper- and hypo-function of the HPA axis. It is likely that this contributes to the pattern of poor physical health and premature mortality suffered by people with schizophrenia, in particular the high rates of cardiovascular and metabolic disturbance.

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