2009
DOI: 10.1016/j.heares.2009.05.003
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Dexamethasone protects auditory hair cells against TNFα-initiated apoptosis via activation of PI3K/Akt and NFκB signaling

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Cited by 114 publications
(123 citation statements)
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“…The decreased levels of p-Akt (S473) in OHCs after exposure to PTS noise are in accordance with early reports that p-Akt (S473) levels decrease after aminoglycoside treatment or with aging (Jiang et al 2006;Chung et al 2006;Haake et al 2009;Sha et al 2010). However, the levels of p-Akt (S473) increase in whole cochlear homogenates according to Western blot analysis, implicating another cochlear cell type in response to PTS noise stress.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…The decreased levels of p-Akt (S473) in OHCs after exposure to PTS noise are in accordance with early reports that p-Akt (S473) levels decrease after aminoglycoside treatment or with aging (Jiang et al 2006;Chung et al 2006;Haake et al 2009;Sha et al 2010). However, the levels of p-Akt (S473) increase in whole cochlear homogenates according to Western blot analysis, implicating another cochlear cell type in response to PTS noise stress.…”
Section: Discussionsupporting
confidence: 90%
“…On the other hand, Akt has been implicated as an integral part of the protein kinase C (PKC) pathway that promotes spiral ganglion neuron survival (Lallemend et al 2005). In rat cochlear explants, treatment with an Akt inhibitor promotes gentamicininduced outer hair cell (OHC) death (Chung et al 2006) and diminishes the protective function of dexamethasone against TNFα-initiated apoptosis (Haake et al 2009). Moreover, inhibition of the downstream Akt target NF-κB by aminoglycosides leads to loss of sensory hair cells in explants (Nagy et al 2005(Nagy et al , 2007 and mouse cochleae (Jiang et al 2006).…”
Section: Introductionmentioning
confidence: 99%
“…In animal models, noise-overstimulation elevated TNF-α and other pro-inflammatory cytokines in the rat cochlea (Fujioka et al 2006), while drugs preventing TNF-α expression prevented loss of outer hair cells following intense noise treatment (Bas et al 2009 In cochlear explants, TNF-α was upregulated by hypoxia, a condition that can lead to hearing loss (Khan et al 2010). Likewise, direct application of TNF-α to cultures of the organ of Corti confirms its toxic effects on hair cells (Haake et al 2009). …”
Section: Discussionmentioning
confidence: 98%
“…Glucocorticoids protect the cochlear hair cells against cytotoxicity (Tahera Y, et al, 2006;Haake SM, et al, 2009) or pathological states such as noise trauma (Tahera Y, et al, 2007;Meltser I, et al, 2009). The supporting cells are known to be related to hair cell regeneration (Löwenheim H, et al, 1999) and ion regulation (Mistrik and Ashmore, 2009 (Kim et al, 2009).…”
Section: Discussionmentioning
confidence: 99%