Dexamethasone Reduces Length of Hospitalization and Improves Postoperative Pain and Nausea After Total Joint Arthroplasty

Backes, Jeffrey; Bentley, Jared C.; Politi, Joel; Chambers, Bryan

doi:10.1016/j.arth.2013.05.041

Cited by 191 publications

(192 citation statements)

References 31 publications

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“…PONV after lower limb surgery also has a reported incidence of 20-83 % [3][4][5][6][7][8]. In addition to the distress or discomfort inflicted on the patient, PONV can be immobilizing, likely increasing the risk of venous thrombosis or pulmonary embolus, interfering with physical therapy, and delaying hospital discharge [9][10][11]. Therefore, there remains a medical need for more effective therapies to prevent PONV, particularly in high-risk patients.…”

Section: Introductionmentioning

confidence: 94%

The effects of intravenous fosaprepitant and ondansetron in the prevention of postoperative nausea and vomiting in patients who underwent lower limb surgery: a prospective, randomized, double-blind study

et al. 2015

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Section: Introductionmentioning

confidence: 94%

The effects of intravenous fosaprepitant and ondansetron in the prevention of postoperative nausea and vomiting in patients who underwent lower limb surgery: a prospective, randomized, double-blind study

et al. 2015

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“…A prophylactic dose of antibiotics is administered within 30 minutes of skin incision and an antiemetic is administered to decrease postoperative nausea. 12 Meticulous cautery of any bleeding points and intravenous tranexamic acid is used to decrease blood loss. [13][14][15] Surgical drains and the use of urinary catheters are avoided.…”

Section: -11mentioning

confidence: 99%

Rapid mobilisation following total hip and knee arthroplasty

Riemer¹,

MacIntyre²,

Nortje³

et al. 2017

SA orthop. j.

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IntroductionTotal joint arthroplasty has become established as a very successful method of treating end-stage arthritis of the hip and knee with excellent long-term outcomes. 1,2 With an ageing population, there is an increased demand for services relating to joint arthroplasty. Individual patient's demands and expectations are also increasing, with patients desiring a quicker return to normal functioning with minimal discomfort after their joint replacement surgery.In today's climate of limited resources and global financial strain we need to investigate ways of containing cost while enabling and maintaining safe effective treatment with optimised results. Any alteration to the surgical management of hip and knee arthroplasty should never compromise patient safety and outcomes. AbstractIntroduction: A rapid recovery protocol for hip and knee replacement surgery is a multidisciplinary, standardised pathway to meet the increasing demands for surgery and enhancement of recovery. This is the idea behind the recent global push by funders for cost effective, elective primary hip and knee arthroplasty. We report on a pilot study to assess the implementation and feasibility of a standardised care pathway in a South African private hospital setting. Materials and methods:Eligible patients presenting for primary hip or knee arthroplasty were enrolled in a rapid recovery programme. The protocol that was implemented was based on current literature and international best practices. It involved members of a multidisciplinary team and the standardisation of the treatment of patients undergoing elective hip and knee arthroplasty.Results: Forty-six patients were enrolled in the pilot study and 43 patients were successfully discharged by the third post-operative day. There were no major complications and high patient satisfaction was recorded. Conclusion:This pilot study successfully implemented a multidisciplinary and standardised treatment protocol for hip and knee arthroplasty in a South African setting. The rapid recovery protocol proved to be safe and effective for the management of hip and knee replacements.

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“…An ideal therapy would retain the benefits of dex on engineered cartilage without the requirement for its exogenous supplementation, obviating the systemic 58 and joint level complications associated with clinical injections of steroids. 59,60 As such, the current study tested the hypothesis that the incorporation of PLGA microspheres (MS), with the ability to release dex from within chondrocyte-seeded agarose hydrogel constructs, would promote development of constructs with native mechanical properties and protect constructs from the deleterious effects of IL-1a, laying the foundation for future, clinically focused studies.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

RoachBrendan

Kelmendi-DokoArta

BalutisElaine

et al. 2016

Tissue Engineering Part A

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Dexamethasone Reduces Length of Hospitalization and Improves Postoperative Pain and Nausea After Total Joint Arthroplasty

Cited by 191 publications

References 31 publications

The effects of intravenous fosaprepitant and ondansetron in the prevention of postoperative nausea and vomiting in patients who underwent lower limb surgery: a prospective, randomized, double-blind study

The effects of intravenous fosaprepitant and ondansetron in the prevention of postoperative nausea and vomiting in patients who underwent lower limb surgery: a prospective, randomized, double-blind study

Rapid mobilisation following total hip and knee arthroplasty

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

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