Dexamethasone reduces pain and swelling following extraction of third molar teeth

Baxendale, Bryn; Vater, Margit; Lavery, K.M.

doi:10.1111/j.1365-2044.1993.tb07474.x

Cited by 248 publications

(166 citation statements)

References 8 publications

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“…It has shown that there is more reduction in pain and trismus following submucosal infiltration of dexamethasone or methylprednisolone rather than control group [13]. According to Milles' study trismus and need of taking extra analgesic medications were not affected by administration of low-dose methylprednisolone [14]; whereas Baxendale et al [15] observed the elimination of analgesic intake by administering pre-operative dexamethasone while trismus was not affected. Various results in pain and mouth opening were found by Shin et al [16] while Bamgbose et al [17] observed better results by administering dexamethasone and diclofenac K rather than diclofenac K alone.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

Moghaddamnia

Nosrati

Mehdizadeh

et al. 2012

J. Maxillofac. Oral Surg.

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Objective The purpose of this study was to compare the effects of prednisolone and celecoxib on pain and maximum mouth opening (MMO) after surgical removal of mandibular third molars. Methods and Materials This double-blind clinical study was conducted upon 60 subjects. These patients received 4 tablets of either 100 mg celecocxib or 5 mg prednisolone: one tablet before surgery and the rest for every 8 h postoperation. The subjects were asked to take acetaminophen codeine as rescue dose. Interincisal distance of upper and lower central teeth and pain measurements (according to Visual Analogue Scale) were taken before surgery, 24 h, 48 h and 7 days after surgery. Results Average pain intensity in 24 h after surgery in patients receiving celecoxib was 3.6 ± 2.5 with significant difference to the other group (p = 0.041), but in subsequent evaluations prednisolone group reported less pain intensity, but the differences were not significant. MMO in 48 h after surgery was lower in prednisolone group (p = 0.640) and in further evaluations the groups were almost similar. Analyzing the data revealed no significant difference between groups in MMO. Conclusion According to this study there is no significant difference in the effects of prednisolone or celecoxib upon MMO, while celecoxib had better results for pain relief in 24 h after surgery in comparison to prednisolone.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

Moghaddamnia

Nosrati

Mehdizadeh

et al. 2012

J. Maxillofac. Oral Surg.

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“…3 Thoracic epidural analgesia with morphine-bupivacaine combination improves pain relief during the first 24 hr following laparoscopic cholecystectomy. 4 Preoperative administration of dexamethasone has been reported to reduce postoperative pain through both oral 5,6 and iv 7,8 routes of administration. While epidural steroids are effective in the treatment of low back pain, 9 their potential postoperative analgesic benefits have not been evaluated.…”

Section: B Enefits Of Laparoscopic Cholecystectomymentioning

confidence: 99%

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Thomas

Beevi

2006

Can J Anesth/J Can Anesth

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Purpose: Epidural steroids may have potential advantages for providing postoperative analgesia. We therefore undertook a study to evaluate the efficacy of epidurally administered dexamethasone in reducing postoperative morphine requirements, as a measure of analgesia following laparoscopic cholecystectomy. Methods:In a randomized, double-blind study, 94 patients undergoing laparoscopic cholecystectomy were randomly assigned to one of three groups. Group 1 (Control) patients received dexamethasone 5 mg iv with epidural injection of 0.25% bupivacaine 8 mL and normal saline 2 mL, Group 2 (D1) patients received normal saline 2 mL iv with epidural injection of 0.25% bupivacaine 8 mL and dexamethasone 5 mg in normal saline 2 mL, and Group 3 (D2) patients received normal saline 2 mL iv with epidural injection of dexamethasone 5 mg in normal saline 10 mL. After surgery, morphine 2-4 mg iv was administered as needed for analgesia. Postoperative morphine requirements, visual analogue scale (VAS) pain scores at rest and with effort, and time to first analgesic administration were recorded by a blinded observer. Results:Total morphine consumption for the first 24 hr following surgery was lower in both epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reduction in morphine consumption in Group D1 was 53.9% and in Group D2 was 52.9% in the first 24 hr. Postoperatively at 12 hr, 18 hr and 24 hr, the VAS scores at rest and during effort were also lower in the epidural dexamethasone groups (D1, D2) compared to the control group (P < 0.05). The percentage reductions in VAS scores with effort at 12 hr, 18 hr and 24 hr in Group D1 were 50%, 52.9% and 50% respectively, and in Group D2 percentage reductions in pain scores with effort were 54.8%, 58.8% and 55.5% at corresponding sampling intervals. Conclusion:Preoperative epidural administration of dexamethasone 5 mg, with or without bupivacaine, reduces postoperative pain and morphine consumption following laparoscopic cholecystectomy. Objectif

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“…4 Il a fallu davantage de temps avant de reconnaître l'action antiémétique puissante de la dexaméthasone, bien que cet effet ait déjà été démontré dans les premières études. 3 Dans les années 1980, la dexaméthasone a trouvé un rôle dans la prévention des vomissements induits par la chimiothérapie; 5 il a toutefois fallu une autre décennie au moins avant que les implications d'une telle découverte pour le contrôle des nausées et vomissements postopératoires (NVPO) soient pleinement appréciées. La Society for Ambulatory Anesthesia a évalué de façon critique les données probantes concernant la prévention et la prise en charge adaptées des NVPO, et les directives qui se sont ensuivies recommandent l'utilisation de dexaméthasone en tant qu'antiémétique prophylactique efficace chez les enfants à la dose de 150 lgÁkg -1 , jusqu'à un maximum de 5 mg. 6 Les autres utilisations périopératoires de la dexaméthasone chez l'enfant se sont concentrées sur l'analgésie après des interventions telles que les amygdalectomies 7 et les orchidopexies.…”

Section: Innocuité Deunclassified

“…2 Over the following two decades, the use of dexamethasone as a potent anti-inflammatory agent was explored, and the drug was soon found to be beneficial in such clinical situations as third molar extraction 3 and acute laryngotracheobronchitis (croup). 4 The potent antiemetic action of dexamethasone was somewhat slower to be recognized, even though this had been shown in early studies.…”

mentioning

confidence: 99%

“…4 The potent antiemetic action of dexamethasone was somewhat slower to be recognized, even though this had been shown in early studies. 3 Dexamethasone found a role in the prevention of chemotherapy-induced vomiting in the 1980s, 5 but it took another decade or more before the implications for the control of postoperative nausea and vomiting (PONV) were fully appreciated. The Society for Ambulatory Anesthesia has critically evaluated the evidence for appropriate prevention and management of PONV, and the ensuing guidelines recommend dexamethasone as an effective prophylactic antiemetic in children at a dose of 150 lgÁkg -1 , up to 5 mg. 6 Other perioperative effects of dexamethasone in children have focused on analgesia after procedures such as tonsillectomy 7 and orchidopexy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Safety of perioperative dexamethasone administration in children: time for reflection?

Yee

Cox

2013

Can J Anesth/J Can Anesth

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Dexamethasone reduces pain and swelling following extraction of third molar teeth

Cited by 248 publications

References 8 publications

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

L’administration péridurale de dexaméthasone réduit la douleur et la demande d’analgésiques postopératoires

Safety of perioperative dexamethasone administration in children: time for reflection?

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