Dexamethasone suppression test in patients with Parkinson's disease

Kostić, Vladimir; Covickovic-Sternic, Nadezda; Beslac-Bumbasirevic, Ljiljana; Ocić, G; Pavlović, Dušan; Nikolić, Milisav

doi:10.1002/mds.870050106

Cited by 13 publications

(4 citation statements)

References 26 publications

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“…However, this estimate was higher in those with a general medical illness (8.9%) or those with two or more medical conditions (16.2%), suggesting a significant association between medical conditions and suicidality that persisted even after adjusting for depressive illness and alcohol use [10]. Disturbances in serotonin neuroregulation and in hypothalamic-pituitary-adrenal axis activity, both likely, and possibly independent factors in the genesis of suicidal behavior, are also reported in PD, particularly if associated with depression [35,36]. Therefore, one may hypothesize that suicidal behavior in PD should be quite prevalent.…”

Section: Discussionmentioning

confidence: 86%

Suicide and suicidal ideation in Parkinson's disease

Kostić¹,

Pekmezović

Tomić³

et al. 2010

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 86%

Suicide and suicidal ideation in Parkinson's disease

Kostić¹,

Pekmezović

Tomić³

et al. 2010

Journal of the Neurological Sciences

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“…The DST has previously been employed to demonstrate alterations in HPA-axis feedback signaling in PD. One early study stratified a small group of patients by the presence of depression and reported that PD patients with depression were more likely to be DST non-suppressors ( 285 ). Rabey et al reported that a significant proportion of idiopathic PD patients were DST non-suppressors (17 of 32 patients; 53%) and had higher basal levels of cortisol and ACTH compared to healthy age-matched controls (20% non-suppressors) ( 286 ).…”

Section: Depression In Parkinson’s Diseasementioning

confidence: 99%

Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?

2015

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There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a variety of neurodegenerative diseases such as Parkinson’s disease (PD) and Huntington’s disease (HD). These affective symptoms may be observed many years before the core diagnostic symptoms of the neurological condition. It is becoming more apparent that depression is a significant modifying factor of the trajectory of disease progression and even treatment outcomes. It is therefore crucial that we understand the potential pathophysiologies related to the primary condition, which could contribute to the development of depression. The hypothalamic–pituitary–adrenal (HPA)-axis is a key neuroendocrine signaling system involved in physiological homeostasis and stress response. Disturbances of this system lead to severe hormonal imbalances, and the majority of such patients also present with behavioral deficits and/or mood disorders. Dysregulation of the HPA-axis is also strongly implicated in the pathology of major depressive disorder. Consistent with this, antidepressant drugs, such as the selective serotonin reuptake inhibitors have been shown to alter HPA-axis activity. In this review, we will summarize the current state of knowledge regarding HPA-axis pathology in Alzheimer’s, PD and HD, differentiating between prodromal and later stages of disease progression when evidence is available. Both clinical and preclinical evidence will be examined, but we highlight animal model studies as being particularly useful for uncovering novel mechanisms of pathology related to co-morbid mood disorders. Finally, we purpose utilizing the preclinical evidence to better inform prospective, intervention studies.

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“…Using these cutoffs, sensitivity, specificity, and positive and negative predictive values for a DSM‐IV diagnosis of major depressive disorder in PD have been found to be acceptable. It has been demonstrated to be sensitive to change in PD patients61–68 and to correlate with biological markers of dPD 69–72…”

Section: Resultsmentioning

confidence: 99%

Melamed–Wolinska bodies in urine cytology an interesting aggregate in a degenerated urothelial cell

Rashidi

Tongson-Ignacio

2011

Diagnostic Cytopathology

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Nanocomposites based on biodegradable poly(butylene adipate‐co‐terephthalate) (PBAT) and layered silicates were prepared by the melt intercalation method. Nonmodified montmorillonite (MMT) and organo‐modified MMTs (DA‐M, ODA‐M, and LEA‐M) by the protonated ammonium cations of dodecylamine, octadecylamine, and N‐lauryldiethanolamine, respectively, were used as the layered silicates. The comparison of interlayer spacing between clay and PBAT composites with inorganic content 3 wt % measured by X‐ray diffraction (XRD) revealed the formation of intercalated nanocomposites in DA‐M and LEA‐M. In case of PBAT/ODA‐M (3 wt %), no clear peak related to interlayer spacing was observed. From morphological studies using transmission electron microscopy, the ODA‐M was found to be finely and homogeneously dispersed in the matrix polymer, indicating the formation of exfoliated nanocomposite. When ODA‐M content was increased, the XRD peak related to intercalated clay increased. Although the exfoliated ODA‐M (3 wt %) nanocomposite showed a lower tensile modulus than the intercalated DA‐M and LEA‐M (3 wt %) composites, the PBAT/ODA‐M composite with inorganic content 5 wt % showed the highest tensile modulus, strength, and elongation at break among the PBAT composites with inorganic content 5 wt %. Their tensile properties are discussed in relation to the degree of crystallinity of the injection molded samples. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 386–392, 2005

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Dexamethasone suppression test in patients with Parkinson's disease

Cited by 13 publications

References 26 publications

Suicide and suicidal ideation in Parkinson's disease

Suicide and suicidal ideation in Parkinson's disease

Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?

Melamed–Wolinska bodies in urine cytology an interesting aggregate in a degenerated urothelial cell

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