Dexmedetomidine added to ropivacaine for transversus abdominis plane block inhibits stress response in laparoscopic surgery: a randomized controlled trial

Qin, Zhaojun; Xiang, Chunyan; Li, Hongbo; Liu, Tingting; Zhan, Li; Xia, Zhengyuan; Zhang, Min; Lai, Jianpin

doi:10.21203/rs.2.388/v1

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It decreased the anaesthetic and opioid consumption. They concluded that adding 0.5 μg/kg dexmedetomidine as an adjuvant for TAP block is the optimal dose to control postoperative pain and surgical stress with limited effects on the patients’ haemodynamics (Qin et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound‐guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double‐blind study

Mostafa

Hamed

Amin

et al. 2020

European Journal of Pain

View full text Add to dashboard Cite

BackgroundLaparoscopic surgeries are associated with less postoperative pain and adverse events compared to open procedures. But, it still reduces the quality of life in children. Transversus abdominis plane (TAP) block is used to reduce pain. We hypothesized that dexmedetomidine or clonidine could improve the analgesic profile of levobupivacaine to the same extent during TAP block in children.MethodsNinety children were randomly allocated in a randomized double‐blind trial to receive bilateral TAP block with levobupivacaine plus normal saline (group B, n = 30), or dexmedetomidine (group D, n = 30) or clonidine (group C, n = 30). Primary outcome was the modified Children's Hospital of Eastern Ontario Pain Scale score. Secondary outcomes included time to initial analgesic request, number of analgesic claims, total analgesic consumption, parents' satisfaction, sedation score and complications.ResultsChildren of group D showed reduced pain scores compared to other groups. They represented the longest period of analgesia (565.00 ± 71.5 min) with p < 0.001, and fewer patients required two doses of analgesia during the first postoperative day. The cumulative amount of backup analgesia was significantly different between these groups (p = 0.026). Higher parents’ satisfaction scores were recorded in groups D and C compared to group B. Sedation among the study groups revealed significant differences (p = 0.035), but no severe complications were recorded.ConclusionsAdding dexmedetomidine to levobupivacaine can extend the time of analgesia and reduce the use of postoperative backup analgesics with minimal sedation effects when used in TAP block in paediatrics undergoing laparoscopic orchiopexy. Clonidine can be used as an alternative adjuvant to local anaesthetics with good postoperative analgesic profiles.SignificanceClonidine can alternate dexmedetomidine during TAP block with local anesthetics for pediatrics laparoscopies. Both can lead to better postoperative analgesic profiles. Clonidine may be preferred, especially in our developing regions, because of its easy availability and lower cost than that of dexmedetomidine.

show abstract

Section: Discussionmentioning

confidence: 99%