2004
DOI: 10.1097/00000542-200403000-00040
|View full text |Cite
|
Sign up to set email alerts
|

Dexmedetomidine and Cardiac Arrest

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
73
1
3

Year Published

2004
2004
2018
2018

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 139 publications
(80 citation statements)
references
References 0 publications
3
73
1
3
Order By: Relevance
“…20 Some cases of dexmedetomidine-induced atrioventricular block followed by cardiac arrest have been reported. 21,22 This critical complication may be associated with direct vagal activation by the α2-adrenergic agonist. Compared with our previous results of electrical cervical vagal nerve stimulation in rabbits, 9 intravenous administration of 100 μg/kg of medetomidine had an effect equivalent to electrical vagal stimulation at 10 Hz.…”
Section: Clinical Implicationmentioning
confidence: 99%
“…20 Some cases of dexmedetomidine-induced atrioventricular block followed by cardiac arrest have been reported. 21,22 This critical complication may be associated with direct vagal activation by the α2-adrenergic agonist. Compared with our previous results of electrical cervical vagal nerve stimulation in rabbits, 9 intravenous administration of 100 μg/kg of medetomidine had an effect equivalent to electrical vagal stimulation at 10 Hz.…”
Section: Clinical Implicationmentioning
confidence: 99%
“…In previous studies applying single‐ or initial‐dose dexmedetomidine sedation in elderly patients, bradycardia and hypotension were the most common side‐effects, and occurred more frequently with dexmedetomidine doses exceeding 0.5 μg/kg 8, 18, 19, 20, 21. Although a previous study reported that maintenance doses of up to 10 μg/kg per hour were tolerated,27 without producing hypotension or bradycardia, when used as a total intravenous anesthetic agent in certain patients, there are other case reports in which the use of dexmedetomidine in elderly patients was associated with the occurrence of severe bradycardia or hypotension,27, 28 sometimes even progressing to asystole. In our study, none of the patients developed clinically significant hemodynamic disturbances requiring intervention.…”
Section: Discussionmentioning
confidence: 95%
“…In this way, we were able to overcome the slow onset of dexmedetomidine sedation. Previously concerns have been raised about cardio-depressant properties [6][7][8] of dexmedetomidine and bradycardia [7,8] has been the most feared adverse effect associated with this agent. However, in the present study no such effect was noted at any time point of observation in any of the subjects.…”
Section: Discussionmentioning
confidence: 99%
“…In healthy adult patients, its administration manifests as a biphasic effect, i.e., an initial increase in systolic blood pressure is followed by reflex decrease in blood pressure [6]. Bradycardia may also be observed [7,8]. The respiratory parameters usually remain stable, yet, a keen watch is required [9,10].…”
Section: Introductionmentioning
confidence: 99%