Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy

Elvan, E. G.; Öç, Bahar; Uzun, Şennur; Karabulut, Erdem; Çoşkun, Fehmi; Aypar, Ülkü

doi:10.1017/s0265021507003110

Cited by 100 publications

(83 citation statements)

References 32 publications

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“…19 The findings of our study are in accordance with Elvan et al who found that shivering was prevented when dexmedetomidine infusion was given in patients undergoing an elective abdominal hysterectomy. 20 Coskuner et al also did not found shivering with the same dose used in our study. 21 Whereas Bicer et al found shivering in 15% of patients with dexmedetomidine following general anesthesia, whereas it was reported in 55% patients who were given placebo.…”

Section: Discussionsupporting

confidence: 74%

“…8 Dexmedetomidine acts as antishivering agent by means it being a α-2-adrenergic receptor agonist with potent effects on the central nervous system. 9 We carried out this study to compare between an intravenous low dose of ketamine and an intravenous infusion of dexmedetomidine for prevention of intraoperative shivering during spinal anesthesia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dexmedetomidine Infusion Versus Intravenous Low-Dose Ketamine Injection In Preventing Intraoperative Shivering During Spinal Anesthesia: A Comparative Study

Reddy¹

2017

JMSCR

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Infusion Versus Intravenous Low-Dose Ketamine Injection In Preventing Intraoperative Shivering During Spinal Anesthesia: A Comparative Study

Reddy¹

2017

JMSCR

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“…In many studies, dexmedetomidine was shown to increase the temperature range without triggering thermoregulatory defenses through stimulation of central α2-adrenergic receptors, thereby decreasing the central thermoregulatory threshold for shivering. [20][21][22] It is possible that the anti-shivering effect of intrathecal dexmedetomidine may be caused by decreasing shivering threshold.…”

Section: Discussionmentioning

confidence: 99%

“…[20][21][22][23] Moreover, robust data on safety of use of IV dexmedetomidine in parturients is largely lacking. Callaway et al reported a decreased incidence of shivering with use of i.v.…”

Section: Discussionmentioning

confidence: 99%

Intrathecal Dexmedetomidine Alleviates Shivering during Cesarean Delivery under Spinal Anesthesia

Liu

et al. 2017

Biological & Pharmaceutical Bulletin

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Shivering associated with spinal anesthesia during Cesarean delivery is an uncomfortable experience for the parturient, which may also cause adverse effects. In this prospective, randomized, double-blind, placebocontrolled study, we sought to evaluate the effect of intrathecal dexmedetomidine, administered as an adjunct to hyperbaric bupivacaine for Cesarean delivery, on the incidence and severity of shivering associated with spinal anesthesia. Patients undergoing Cesarean delivery were randomly allocated to three groups of 30 patients each. Experimental treatments were added to hyperbaric bupivacaine as follows: Patients in group I (control) were administered isotonic saline. Patients in groups II and III received dexmedetomidine (2.5, 5 µg, respectively), mixed with isotonic saline. Shivering was observed in 11, 10 and 2 patients in groups I, II and III, respectively. The incidence of shivering in group III was significantly lower than that in groups I (p 0.005) and II (p 0.01). The severity of shivering was significantly different between the three groups (p 0.01). There were no significant inter-group differences with respect to mean arterial pressure and heart rate at any time point after administration of intrathecal local anesthesia (p>0.05). Intrathecal dexmedetomidine (5 µg) administered as an adjunct to hyperbaric bupivacaine during Cesarean delivery significantly reduced the incidence and intensity of shivering associated with spinal anesthesia.

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“…3,9,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Other control agents included fentanyl, [33][34][35][36] remifentanyl, 37,38 meperidine, 15 midazolam, [39][40][41] propofol, 43,44 ketamine, 45,46 tramadol, 24,47 clonidine, 42 propacetamol, 48 and buprenorphine 49 ( 8 were reported in the 39 included trials, and all studies reported every endpoint mentioned in the Methods section (reporting bias). 8 however, some bias 8 may exist in of the two trials, 27,32 as the length of surgery was not clear.…”

Section: Study Characteristicmentioning

confidence: 99%

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

Liu

Liang

et al. 2015

Can J Anesth/J Can Anesth

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Purpose Shivering is a frequent complication in the postoperative period. The aim of the current meta-analysis was to assess the efficacy of dexmedetomidine on postoperative shivering. with a minimum effective dose of 0.5 lgÁkg -1 (RR = 0.36; 95% CI: 0.21 to 0.60). The anti-shivering effect can be achieved both intravenously and epidurally when administered within two hours prior to the end of surgery. The efficacy of dexmedetomidine was similar to widely used anti-shivering agents, such as fentanyl, meperidine, tramadol, clonidine and so on; however, dexmedetomidine may increase the incidence of sedation, hypotension, bradycardia and dry mouth. Conclusions The present meta-analysis indicates that dexmedetomidine shows superiority over placebo, but not over other anti-shivering agents. Therefore, considering its high price and potential adverse events, dexmedetomidine may not be appropriate solely for the purpose of the prevention of postoperative shivering. RésuméObjectif Les frissons sont une complication fréquente en période postopératoire. L'objectif de cette méta-analyse était d'évaluer l'efficacité de la dexmédétomidine pour contrô ler les frissons postopératoires.

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Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy

Abstract: Intraoperative dexmedetomidine infusion may be effective in the prevention of post-anaesthetic shivering.

Cited by 100 publications

References 32 publications

Dexmedetomidine Infusion Versus Intravenous Low-Dose Ketamine Injection In Preventing Intraoperative Shivering During Spinal Anesthesia: A Comparative Study

Dexmedetomidine Infusion Versus Intravenous Low-Dose Ketamine Injection In Preventing Intraoperative Shivering During Spinal Anesthesia: A Comparative Study

Intrathecal Dexmedetomidine Alleviates Shivering during Cesarean Delivery under Spinal Anesthesia

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

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