Dexmedetomidine combined with narcotic anesthesia induction in coronary artery bypass graft surgery

Gümüş, Funda

doi:10.5606/tgkdc.dergisi.2013.7813

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…[10,14] Although they are short-termed, myocardial oxygen demand may increase and may lead to myocardial ischemia in patients with coronary artery disease. [15] To prevent Rate pressure product…”

Section: Discussionmentioning

confidence: 99%

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Comparison of hemodynamic responses to endotracheal intubation with the GlideScope video laryngoscope and Macintosh laryngoscope in patients undergoing cardiovascular surgery

İnangil

Cansız

Gürbüz

et al. 2018

Turk Gogus Kalp Dama

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Section: Discussionmentioning

confidence: 99%

“…[3,4,15,16] Lidocaine is an amid-type local anesthetic which is also classified as class IB antiarrhythmic drug, as it has antagonistic action on voltage-gated sodium channels. Lidocaine also inhibits N-methyl-D-aspartate (NMDA) receptors.…”

Section: Macintoshmentioning

confidence: 99%

Comparison of hemodynamic responses to endotracheal intubation with the GlideScope video laryngoscope and Macintosh laryngoscope in patients undergoing cardiovascular surgery

İnangil

Cansız

Gürbüz

et al. 2018

Turk Gogus Kalp Dama

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“…Dexmedetomidine (DEX) is a novel type of highly selective α2-adrenergic receptor agonist and has been used as a sedative or adjuvant anesthetic drug to maintain more stable hemodynamic parameters for patients undergoing cardiac surgery. 5 The original application for DEX was the short-term sedation for adult patients in the intensive care unit (ICU) who were receiving invasive mechanical ventilation. Then DEX received approval for monitored anesthesia care in adults in 2008.…”

Section: Introductionmentioning

confidence: 99%

Does Dexmedetomidine Reduce the Risk of Atrial Fibrillation and Stroke After Adult Cardiac Surgery? A Systematic Review and Meta-analysis of Randomized Controlled Trials

Jing¹,

Lin²,

Zhou³

et al. 2022

Anatolian J Cardiol

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Background Postoperative atrial fibrillation is a common consequence of cardiac surgery with increased stroke complications and mortality. Although dexmedetomidine is thought to prevent postoperative atrial fibrillation and stroke because of its sympatholytic and anti-inflammatory properties, data from different studies show the effect of dexmedetomidine on postoperative atrial fibrillation and stroke uncertain in adult patients with cardiac surgery. Methods A database including EMBASE, PubMed, and Cochrane CENTRAL was searched for randomized controlled trials comparing dexmedetomidine with placebo or other anesthetic drugs in adult cardiac surgery. The primary outcome was the incidence of postoperative atrial fibrillation. The secondary outcomes were the incidence of postoperative stroke, mechanical ventilation duration, intensive care unit length of stay, hospital length of stay, and mortality. Results Eighteen trials with a total of 2933 patients were enrolled in the meta-analyses. Compared with controls, dexmedetomidine significantly reduced the incidence of postoperative atrial fibrillation [odds ratio, 0.82; 95% CI, 0.69-0.98; P = .03]. There was no significant difference between groups in stroke (odds ratio, 1.36; 95% CI, 0.59-3.16; P = .47), mechanical ventilation duration [weighted mean difference, −0.17; 95% CI, −0.35 to 0.14; P = .39], intensive care unit length of stay (weighted mean difference, −0.03; 95% CI, −0.93 to 0.87; P = .95), hospital length of stay (weighted mean difference, −0.04; 95% CI, −0.40 to 0.32; P = .83) and mortality (odds ratio, 0.72; 95% CI, 0.32-1.60; P = .42). Conclusion Perioperative dexmedetomidine reduced the incidence of postoperative atrial fibrillation in adult patients undergoing cardiac surgery. But there was no significant difference in the incidence of stroke, mechanical ventilation duration, intensive care unit length of stay, hospital length of stay, and mortality.

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Dexmedetomidine combined with narcotic anesthesia induction in coronary artery bypass graft surgery

Cited by 2 publications

References 24 publications

Comparison of hemodynamic responses to endotracheal intubation with the GlideScope video laryngoscope and Macintosh laryngoscope in patients undergoing cardiovascular surgery

Comparison of hemodynamic responses to endotracheal intubation with the GlideScope video laryngoscope and Macintosh laryngoscope in patients undergoing cardiovascular surgery

Does Dexmedetomidine Reduce the Risk of Atrial Fibrillation and Stroke After Adult Cardiac Surgery? A Systematic Review and Meta-analysis of Randomized Controlled Trials

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