Dexmedetomidine Sedation After Tracheal Surgery: A Prospective Pilot Study

Fiorelli, Silvia; Creazzola, F.; Massullo, Domenico; Defraia, Veronica; Maggi, Luigi; Rocco, Monica; Rendina, Erino Angelo

doi:10.1016/j.athoracsur.2019.01.047

Cited by 6 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And can be awakened by external stimuli or language without affecting respiratory function [ 15 , 16 ]. Moreover, it has analgesic effect on α 2 receptors in the spinal cord and cooperates with inhaled anesthetics; opioid analgesics to produce good analgesia and the sedative effect can reduce the dosage of other anesthetics, analgesic, and hypnotic drugs and ensure the safety of anesthesia [ 17 , 18 ]. The use of dexmedetomidine can improve the tolerance of obese patients to tracheal intubation, reduce postoperative agitation, and realize awake extubation, which is conducive to postoperative recovery after laparoscopic bariatric surgery.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dexmedetomidine on Postoperative Pain and Recovery Time in Obese Patients

Zhang

Wang

et al. 2022

Disease Markers

View full text Add to dashboard Cite

Objective. The objective of this study is to investigate the effect of dexmedetomidine on postoperative pain and recovery time in obese patients. Methods. A total of 100 obese patients with body mass index BMI ≥ 30 kg/m2 who underwent laparoscopic sleeve gastrectomy under general anesthesia in our hospital from January 2019 to December 2021 were included and assigned into DEX group (dexmedetomidine group) and NS group (normal saline group). The bariatric surgery patients who were given normal saline pump were the NS group ( n = 50 ), and the bariatric surgery patients who were given the dexmedetomidine pump were the DEX group ( n = 50 ). The patients in the DEX group were given continuous intravenous infusion of dexmedetomidine before, during, and after induction of anesthesia at a dose of 0.4 μg. kg-1. h-1, 0.4 μg·kg-1. h-1, 0.2 μg·kg-1. h-1, respectively. The NS group was infused with the same volume of normal saline for the same time. The two groups of patients were treated with the same anesthesia induction and maintenance program. By comparing the operation, anesthesia, postoperative extubation, and recovery time of the two groups of patients, the effect of dexmedetomidine on the postoperative recovery time of obese patients was analyzed. Visual analogue scale (VAS) and adverse reactions were compared to analyze the effect of dexmedetomidine on postoperative pain in obese patients. Results. The operation, anesthesia, postoperative extubation, and recovery time of the DEX group were significantly lower than those of the NS group, whereas the VAS and adverse reactions were significantly lower than those in the NS group ( P < 0.05 ). Conclusion. An appropriate dose of dexmedetomidine in bariatric surgery for morbidly obese patients can effectively shorten the recovery time and extubation time of patients, reduce postoperative pain and the incidence of adverse reactions, and is worthy of clinical application. Dexmedetomidine 2 μg/kg has promising anesthesia benefits in bariatric surgery of obese patients, can provide favorable analgesia and quality of recovery, help reduce the degree of stress response of patients, and does not increase the risk of adverse events. However, this study has certain limitations, so physicians should tailor the dosage according to the patient’s physical condition in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Dexmedetomidine on Postoperative Pain and Recovery Time in Obese Patients

Zhang

Wang

et al. 2022

Disease Markers

View full text Add to dashboard Cite

show abstract

“…It is paramount to bear in mind that dexmedetomidine significantly decreases mean arterial pressure and heart rate. 26 However, further studies are needed to compare the best treatment strategy for analgesia and sedation in the postoperative care of these patients.…”

Section: Discussionmentioning

confidence: 99%

“… 9 , 14 These findings contrast with other authors’ cohorts, where an uncuffed nasal endotracheal tube is left in place during the first postoperative day and then removed after bronchoscopic review of the anastomosis. 26 Early extubation avoids positive pressure or endotracheal tube cuff trauma to the new anastomosis, factors that may contribute to anastomotic complications. If extubation cannot be performed, keeping spontaneous ventilation with a small-caliber tube without insufflating the cuff is recommended, with another extubation attempt 24 hours later, under direct supervision.…”

Section: Discussionmentioning

confidence: 99%