2020
DOI: 10.21203/rs.3.rs-18652/v1
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Dexmedetomidine versus ketamine in attenuating neuropathic pain through modulating STING/TBK pathway to modulate spinal ER-phagy in neuropathic pain model

Abstract: Background: Our previous studies suggested that stimulator of interferon genes (STING) level was altered in medial prefrontal cortex (mPFC) of spinal nerve ligation (SNL) rats. Methods:In this study, we investigated that whether dexmedetomidine and ketamine provide antianxiety and anti-nociceptive effects via modulating spinal STING/TBK pathway to alter ER-phagy in SNL rats. We evaluated the analgesia and antianxiety effects of ketamine and dexmedetomidine in SNL rats. 2'3'-cGAMP (STING pathway agonist) was ad… Show more

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