Dextran derivatives

Kol'tsova, G. N.; Khachatur'yan, A. A.; Doronina, T. N.; Васильев, А. Э.; Rozenberg, G. Ya.

doi:10.1007/bf00563724

Cited by 2 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same manner, dextran esters of ketoprofen, diclofenac, ibuprofen and fenoprofen can be studied showing that the dextran ester prodrug approach provides selective colon delivery systems of drugs possessing a carboxylic acid functional group [183,184]. The introduction of N-acylamino acid into the dextran backbone is achievable in the same manner [185,186].…”

Section: Activation Of Carboxylic Acids With Sulfonic Acid Chloridesmentioning

confidence: 99%

“…Among the first attempts for the esterification of polysaccharides via CDI is the binding of amino acids onto dextran. Besides CDI, N,N -(thiocarbonyl)diimidazole can be utilised to obtain the corresponding imidazolide [198]. The amino acids bound via this path are glycine, l-leucine, l-phenylalanine, l-histidine and l-alanyll-histidine.…”

Section: Nn -Carbonyldiimidazole (Cdi) As Esterification Reagentmentioning

confidence: 99%

See 1 more Smart Citation

Functional Polymers Based on Dextran

Heinze

Liebert

Heublein

et al.

Advances in Polymer Science

253

198

View full text Add to dashboard Cite

Dextran, comprising a family of neutral polysaccharides consisting of an α-(1→6) linked d-glucose main chain with varying proportions of linkages and branches, depending on the bacteria used, is an interesting starting material for chemical modification reactions for the design of new functional polymers with promising properties. The review summarises recent results on structure characterisation of dextran including some comments on biosynthesis of this important class of biopolymers. Applications of dextran are discussed as well. Chemical modification reactions of dextran are increasingly studied for the structure and hence property design. The review highlights recent progress in esterification of dextran, both inorganic and organic polysaccharide esters, etherification reactions towards ionic and non-ionic ethers, and the huge variety of different conversions mainly developed for the binding of drugs. It summarises recent developments in the application of dextran derivatives with a focus on the chemical structures behind these materials such as prodrugs, bioactivity of inorganic dextran esters, heparin sulfate mimics, hydrogels, nanoparticles and self assembly structures for surface modification. Keywords Functionalised dextran • Structural analysis • Prodrugs • Nanostructures • Bioactivity Abbreviations AFM Atomic force microscopy AGU Anhydroglucose units AT Antithrombin AZT Azidothymidine BSH Na 2 B 12 H 11 SH BSA Bovine serum albumin CAC Critical association concentration CDI N,N -Carbonyldiimidazole CMC Critical micelle concentration CMD Carboxymethyl dextran CMDB Carboxymethyl dextran benzylamide CMDBSSu Carboxymethyl dextran benzylamidesulfonate sulfate CMDBSu Carboxymethyl dextran benzylamide sulfate CMDEE Carboxymethyl dextran ethyl ester CMDSu Carboxymethyl dextran sulfate COSY Two-dimensional correlated spectroscopy CsA Cyclosporin A 2D Two-dimensional Dach-Pt cis-Dihydroxo(cyclohexane-trans-l-1,2-diamine)platinum II DCC N,N -Dicyclohexylcarbodiimide T. Heinze et al.

show abstract

Section: Activation Of Carboxylic Acids With Sulfonic Acid Chloridesmentioning

confidence: 99%

Section: Nn -Carbonyldiimidazole (Cdi) As Esterification Reagentmentioning

confidence: 99%

Functional Polymers Based on Dextran

Heinze

Liebert

Heublein

et al.

Advances in Polymer Science

253

198

View full text Add to dashboard Cite

show abstract

“…In addition to CDI, N,N -(thiocarbonyl)diimidazole can be utilised to obtain the corresponding imidazolide [229]. The amino acids utilised are glycine, l-leucine, l-phenylalanine, l-histidine, and l-alanyl-l-histidine.…”

Section: Nn -Carbonyldiimidazolementioning

confidence: 99%