Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Iakobson, Olga; Добродумов, А. В.; Saprykina, Natalia; Шевченко, Н. Н.

doi:10.1002/macp.201600523

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…Dextran segments count for the hydrophilic shielding and negative charges in the mixed NPs. Although this seems surprising, there had been several reports that suggest negative surface charges on dextran. − We suppose that the negative charge may be due to the ample hydroxy groups in dextran . More specifically, the OH-2 of dextran is more acidic than that of normal hydroxy because of its proximity to the anomeric center .…”

Section: Resultsmentioning

confidence: 94%

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Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation

Li¹,

Sun

et al. 2018

ACS Appl. Mater. Interfaces

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Traditional charge-conversion nanoparticles (NPs) need the breakage of acid-labile groups on the surface, which impedes the rapid response to the acidic microenvironment. Here, we developed novel rodlike charge-conversion NPs with amphiphilic dextran- b-poly(lactic- co-glycolic acid), poly(2-(dimethylamino) ethylmethylacrylate)- b-poly(ε-caprolactone), and an aggregation-induced emission-active probe through flash nanoprecipitation (FNP). These NPs exhibit reversible negative-to-positive charge transition at a slightly acidic pH relying on the rapid protonation/deprotonation of polymers. The size and the critical charge-conversion pH can be further tuned by varying the flow rate and polymer ratio. Consequently, the charge conversion endows NPs with resistance to protein adsorption at physiological pH and enhanced internalization to cancer cells under acidic conditions. Ex vivo imaging on harvest organs shows that charge-conversion NPs were predominantly distributed in tumors after intravenous administration to mice due to the robust response of NPs to the acidic microenvironment in tumor tissue, whereas control NPs or free probes were broadly accumulated in tumor, liver, kidney, and lung. These results suggest the great potential of the current FNP strategy in the facile and generic fabrication of charge-conversion NPs for tumor-targeting delivery of drugs or fluorescent probes.

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Section: Resultsmentioning

confidence: 94%

“…31−33 We suppose that the negative charge may be due to the ample hydroxy groups in dextran. 33 More specifically, the OH-2 of dextran is more acidic than that of normal hydroxy because of its proximity to the anomeric center. 34 ED (Table S1).…”

Section: Synthesis Of Pdmaema-b-pclmentioning

confidence: 99%

Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation

Li¹,

Sun

et al. 2018

ACS Appl. Mater. Interfaces

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“…It was observed that the use of GMA as cross-linker resulted in large nanoparticles due to the formation of less dense cross-linked networks arising from a self-polymerized, longer GMA chain spacer. Ionic surfactant resulted in smaller nanoparticles because of the steric stabilization of dextran nanoparticles …”

Section: Synthesis Of Carbohydrate-based Nanoparticlesmentioning

confidence: 99%

“…Ionic surfactant resulted in smaller nanoparticles because of the steric stabilization of dextran nanoparticles. 156 -L)-based nanoparticles of 200 nm diameter loaded with porcine placenta hydrolysate by a selfassembling process. First, amphiphilic vinyl laurate-conjugated dextran-based polymer (Dex-L) was synthesized by lipasecatalyzed transesterification between dextran and vinyl laurate.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Engineering Carbohydrate-Based Particles for Biomedical Applications: Strategies to Construct and Modify

Thodikayil

Sharma

Saha

2021

ACS Appl. Bio Mater.

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Carbohydrate-based micro/nanoparticles have gained significant attention for various biomedical applications such as targeted/triggered/controlled drug delivery, bioimaging, biosensing, etc., because of their prominent characteristics like biocompatibility, biodegradability, hydrophilicity, and nontoxicity as well as nonimmunogenicity. Most importantly, the ability of the nanoparticles to recognize specific cell sites by targeting cell surface receptors makes them a promising candidate for designing a targeted drug delivery system. These particles may either comprise polysaccharides/glycopolymers or be integrated with various polymeric/inorganic nanoparticles such as gold, silver, silica, iron, etc., to reduce the toxicity of the inorganic nanoparticles and thus facilitate their cellular insertion. Various synthetic methods have been developed to fabricate carbohydrate-based or carbohydrate-conjugated inorganic/polymeric nanoparticles. In this review, we have highlighted the recently developed synthetic approaches to afford carbohydrate-based particles along with their significance in various biomedical applications.

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“…[16][17][18][19][20] In addition, dextran has been widely applied in the medical and biomedical fields with its high solubility, biocompatibility, and degradability in certain physical environments. [21][22][23][24] Here, we graft thioether groups onto dextran through ester and carbonate bonds, respectively. The synthesis of grafted dextran can be accomplished in a simple and efficient two-step process, which takes less time and has a higher yield compared to main-chain polymerization.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of ROS‐Responsiveness of Dextran with Thioether Side Chains

Xia

Chen

et al. 2022

Macro Chemistry & Physics

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Reactive oxygen species (ROS) -responsive polymers based on thioether are widely used for drug delivery platforms for inflammation. However, the responsiveness of polymers containing thioether is not tunable toward acute and chronic inflammation, respectively. Here, two kinds of thioether molecules are grafted onto the hydroxyl groups of dextran in a simple and efficient manner. The grafted dextrans possess similar macromolecular structure and molecular weight and easily form nanoparticles. Cytotoxicity experiments confirm the good biocompatibility and antioxidant properties of the nanoparticles. The grafted dextran responds to typical ROS molecules in the order of ClO − , KO 2 , and H 2 O 2 . As for H 2 O 2 , the grafted dextran with ester group responds much faster than that of the carbonate group, with the former responding six times faster than the latter, which provides opportunities for the treatment of acute and chronic inflammation, respectively. It is demonstrated that the ester group near the thioether renders the oxidation reaction easier than that of carbonate groups because of its lower energy barrier, which is directly confirmed by an in situ nuclear magnetic resonance (NMR) investigation of the reaction between model molecules and H 2 O 2 and theoretical computational simulations. In conclusion, the ROS responsiveness of grafted dextran can be tunable and the grafted dextran exhibits the potential application in inflammation-involved disease.

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Dextran Nanoparticles Cross‐Linked in Aqueous and Aqueous/Alcoholic Media

Cited by 12 publications

References 28 publications

Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation

Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation

Engineering Carbohydrate-Based Particles for Biomedical Applications: Strategies to Construct and Modify

Manipulation of ROS‐Responsiveness of Dextran with Thioether Side Chains

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