Dextran-PLGA-loaded docetaxel micelles with enhanced cytotoxicity and better pharmacokinetic profile

Raza, Kaisar; Kumar, Nitesh; Misra, Charu; Kaushik, Lokesh; Guru, Santosh Kumar; Kumar, Pramod; Malik, Ruchi; Bhushan, Shashi; Katare, Om Prakash

doi:10.1016/j.ijbiomac.2016.03.064

Cited by 71 publications

(22 citation statements)

References 21 publications

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“…Apart from this, the immunoneutrality is pointed out as an advantageous feature of DEX, providing protection against the reticuloendothelial system. [78] Chemically similar to DEX-PLGA, copolymers of PLGA and PUL can also be produced. [79] Among the different amphiphilic polymeric materials in which PLGA is involved, this type of copolymers could be a promising option, mainly due to the nontoxic, nonimmunogenic, noncarcinogenic, and naturally nonmutagenic properties of PUL.…”

Section: Amphiphilic Copolymersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

213

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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Section: Amphiphilic Copolymersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

213

133

View full text Add to dashboard Cite

show abstract

“…Another potential nanostructure for drug delivery is represented by polymeric micelles, which are composed of amphiphilic copolymers. Raza et al [60] explored the potential of a new DTX-loaded polymeric micelles, composed of tethered poly(lactic-co-glycolic acid) (PLGA) and dextran, a biocompatible polysaccharide, which was chemically linked to PLGA, with advantages, such as immuno-neutrality and better pharmacokinetic profile. The in vitro study on MCF-7 and MDA-MB-231 cell lines demonstrated enhanced cytotoxicity of approximately 100%, in both cell cultures.…”

Section: Introductionmentioning

confidence: 99%

A Critical Review of Properties and Analytical Methods for the Determination of Docetaxel in Biological and Pharmaceutical Matrices

Hanck-Silva

Fernandes

Trevizan

et al. 2018

Critical Reviews in Analytical Chemistry

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Docetaxel (DTX) is an antineoplastic agent of the second generation of the taxoid family. It is a semi-synthetic drug prepared from a precursor extracted of the plant Taxus baccata. The commercial formulation of DTX, Taxotere®, employs the surfactant polysorbate 80, due to the low water solubility of the drug, causing several side effects. Therefore, there is a need to develop delivery systems to reduce the side effects of DTX. In addition, this drug has been qualitative and quantitatively analyzed in pharmaceutical formulations and biological samples. Thus, several techniques and analytical methods have been reported with the aim of optimizing the analytical signal, increasing sensitivity, selectivity and reducing the effects of interference. Herein, we highlight immunoassay, capillary electrophoresis and chromatographic methods. This review presents a summary of physicochemical and pharmacokinetics properties, mechanisms of action, drug delivery systems and analytical methods used in quantification of DTX in diverse matrices such as blood, plasma, oral fluid, urine, carcinoma cells, pharmaceutical formulations and delivery systems.

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“…14,15 The hydrophobic segments of micelles become packed together in aggregates (core), which serve as a storage site for poorly water-soluble drugs and can act as a nanodepot for these agents. 16,17 The common advantage of these drug delivery systems is that micelles are resistant to glomerular filtration, which could extend their retention time in the blood.…”

mentioning

confidence: 99%

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

Li¹,

Deng²,

Yuan³

et al. 2017

IJN

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Dextran-PLGA-loaded docetaxel micelles with enhanced cytotoxicity and better pharmacokinetic profile

Cited by 71 publications

References 21 publications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

A Critical Review of Properties and Analytical Methods for the Determination of Docetaxel in Biological and Pharmaceutical Matrices

Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury

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