2017
DOI: 10.1155/2017/4929857
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Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite

Abstract: Drug targeting to specific organs and tissues is one of the crucial endeavors of modern pharmacotherapy. Controlled targeting at the site of action and reduced time of exposure of nontargeted tissues increase the efficacy of the treatment and reduce toxicity and side effects, improving compliance and convenience. Nanocarriers based on the branched copolymers dextran-graft-polyacrylamide were synthesized and characterized and were tested on phagocytic cells. It was shown that these nanoparticles are actively ca… Show more

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Cited by 35 publications
(32 citation statements)
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“…The choice of this copolymer among the series of the branched samples synthesized is based on our previous research. Namely, this sample was the most efficient polymer matrix for the Ag sol in situ synthesis [24,25,29].…”
Section: Polymer Nanocarriermentioning
confidence: 99%
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“…The choice of this copolymer among the series of the branched samples synthesized is based on our previous research. Namely, this sample was the most efficient polymer matrix for the Ag sol in situ synthesis [24,25,29].…”
Section: Polymer Nanocarriermentioning
confidence: 99%
“…The results revealed a dose-dependent decrease in the viability for U-937 and K-562 cell lines exposed to silver. However, when the copolymers were conjugated to both nanosilver and cisplatin, such a nanosystem displayed a less cytotoxic effect compared to the conjugates of polymer and cis-Pt [29].…”
Section: Introductionmentioning
confidence: 97%
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