Dextran sulfate as a leukocyte-endothelium adhesion molecule inhibitor of                 lung injury in pediatric open-heart surgery

Komai, Hiroyoshi; Naito, Yasuaki; Okamura, Yoshitaka

doi:10.1191/0267659105pf788oa

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…No toxic effect of DSS on the lungs has been reported. On the contrary, it has been reported that DSS prevents pulmonary capillary pressure changes, and DSS has even been used in open heart surgery to prevent lung injury in recent years, with successful results [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

Aydın

Songür

et al. 2016

Korean J Intern Med

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Background/Aims:Inflammatory bowel disease (IBD) may also involve various extra-intestinal organs. Clinical studies have found asymptomatic/symptomatic pulmonary involvement in 1% to 6% of patients with IBD. The present study histopathologically investigated pulmonary involvement in an experimental model of colitis in order to demonstrate pulmonary tissue involvement in IBD and to expose potential etiological factors. It also explored the relation between inflammation and tissue concentrations of vascular endothelial growth factor (VEGF) and tumor necrosis factor α (TNF-α).Methods:The study comprised 24 male Wistar albino rats. The rats were divided into four groups of six rats each. Acute colitis was induced in two separate groups using either the dextran sulphate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS) method, while the other two groups were used as controls for each model of colitis. Wallace scoring was used for macroscopic assessment of colitis, and the lungs were histopathologically examined. Concentrations of VEGF and TNF-α in pulmonary tissue were measured by the enzyme-linked immunosorbent assay method.Results:The number of animals that had alveolar hemorrhage was significantly higher in the TNBS-induced colitis and DSS-induced colitis groups compared to their own control groups (p = 0.015 and p = 0.015, respectively). VEGF and TNF-α concentrations in pulmonary tissues were significantly increased in both the TNBS colitis and DSS colitis groups compared to their own control groups (p = 0.002 and p = 0.004, respectively; and p = 0.002 and p = 0.002, respectively).Conclusions:The present study demonstrated that significant and serious histopathological changes directly associated with colitis occur in the lungs in IBD.

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Section: Discussionmentioning

confidence: 99%

Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

Aydın

Songür

et al. 2016

Korean J Intern Med

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“…Furthermore, preservation of perioperative RV function by DXS may be central to ensure optimal postoperative recovery. Indeed, the use of DXS (MW 8000) during CPB in a pediatric population has been shown to ameliorate immediate post-CPB respiratory index [15].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, DXS in part improved the hemodynamic situation by ameliorating diastolic LV function and RV-and pulmonary artery pressures post-CPB. Whilst DXS has been used in a few patient trials [25], including CPB in children, [15] larger randomized clinical trials would be needed before judging the possible importance of the use of DXS in altering current clinical practice. However, in light of the fact that DXS at the current dose was not associated with any adverse events and was well tolerated, it remains to be substantiated whether a more aggressive treatment regimen, evaluated in a longer post-CBP follow-up and ultimately analyzed in human trials, may more markedly and sustainably improve post-CPB cardiac function and outcome.…”

Section: Study Limitationsmentioning

confidence: 99%

Addition of dextran sulfate to blood cardioplegia attenuates reperfusion injury in a porcine model of cardiopulmonary bypass☆

Banz

Rieben

Zobrist

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…104 It was also found to improve significantly post-CPB respiratory index in pediatric patients. 105 Continuous ultrafiltration during CPB decreases pulmonary edema and improves lung function through increasing pCOP as well as removing inflammatory mediators. 45 Methods such as RAP and colloidal prime have also been found to minimize EVLW following CPB.…”

Section: Pulmonary Edemamentioning

confidence: 99%

Cardiopulmonary bypass and edema: physiology and pathophysiology

Hirleman

Larson

2008

Perfusion

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Edema is a common morbidity following cardiopulmonary bypass (CPB) and can result in injury to many organs, including the heart, lungs, and brain. Generalized edema is also common and can lead to increased post-operative hospital stay and other morbidities. Pediatric patients are more susceptible to post-CPB edema and the consequences are more severe for this population. Hemodilution and systemic inflammatory responses are two suspected causes of CPB-related edema; however, the mechanisms involved are far from understood. Also, the common strategies to improve edema have not been completely successful and there is a need for new strategies at maintaining a fluid balance of patients as close to physiological as possible, especially for pediatric patients. An integrative approach to understanding edema is necessary as the forces involved in fluid homeostasis are dynamic and interdependent. Therefore, this review will focus on the physiology of fluid homeostasis and the pathologies of fluid shifts during CPB which lead to general edema as well as tissue-specific edema.

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Dextran sulfate as a leukocyte-endothelium adhesion molecule inhibitor of lung injury in pediatric open-heart surgery

Abstract: The data suggeste the possible effects of dextran sulfate in ameliorating post-perfusion lung damage by interfering with leukocyte-endothelial cell adhesion in pediatric open-heart operations. Future application to patients with more complex anomalies is anticipated.

Cited by 11 publications

References 24 publications

Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis

Addition of dextran sulfate to blood cardioplegia attenuates reperfusion injury in a porcine model of cardiopulmonary bypass☆

Cardiopulmonary bypass and edema: physiology and pathophysiology

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